Mackerel-induced urticaria and Anisakis

Kasuya, Shiro; Hamano, Hirokazu; Izumi, Shigeko

doi:10.1016/0140-6736(90)90455-e

Cited by 121 publications

(77 citation statements)

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“…Due to the high incidence of infection of fish by anisakids (281), it is striking that only a few individuals appear to be susceptible to both anisakiasis and overt A. simplex allergy. Furthermore, despite the worldwide A. simplex parasitism of fish (281), the first cases of A. simplex allergy were detected in Japan (138,139) and then in the Basque Country (northern Spain) (25,28). If we can assume that this is due not merely to higher levels of infection in these regions or to underdiagnosis or a lack of unawareness, there could be some form of genetic predisposition that requires investigation (29,32,33,87).…”

Section: Human Susceptibility Factorsmentioning

confidence: 99%

“…Some patients develop syndromes simultaneously exhibiting clinical manifestations of allergy and infection after eating living parasites; this was first described by Kasuya and coworkers (138,139) and represents a borderline disease between parasitic infection and allergy termed "gastroallergic anisakiasis" (71).…”

Section: Epidemiology Anisakidosismentioning

confidence: 99%

“…In the case of A. simplex, the skin prick test was first used in 1995 (25), and since then its use has been widespread among allergy clinicians as a valuable screening test in cases of urticaria and anaphylaxis (29,50,69,82). Other Japanese authors have reported preliminary studies using intradermal and scratch tests to investigate allergic manifestations associated with anisakidosis (125,139), but these two techniques are no longer recommended as primary tests for the diagnosis of IgE-mediated allergic diseases or for research purposes by the European and American Academies of Allergy.…”

Section: A Simplex Allergy In Humans (I) General Aspects the Potenmentioning

confidence: 99%

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Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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Section: Human Susceptibility Factorsmentioning

confidence: 99%

Section: Epidemiology Anisakidosismentioning

confidence: 99%

Section: A Simplex Allergy In Humans (I) General Aspects the Potenmentioning

confidence: 99%

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Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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“…Since 1990, fish parasites of the genus Anisakis have been recognised to contribute to fishrelated anaphylaxis (Kasuya et al, 1990). The ingestion of seafood contaminated with thirdstage Anisakis larvae can induce a specific IgE response and elicit a reaction, usually urticaria but sometimes anaphylaxis, even when the fish is cooked.…”

Section: Other Fish-related Allergensmentioning

confidence: 99%

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

2004

EFS2

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“…As medically important parasites, Anisakis simplex third stage larvae (L3) frequently give rise to allergic responses and have been investigated intensively by several research groups [1, 2, 3, 4, 5]. Currently, the diagnosis of an L3-dependent allergy is established both by the demonstration of the presence of L3-specific IgE antibodies using either indirect ELISA or Western blot, and by the patient’s history of marine fish consumption.…”

Section: Introductionmentioning

confidence: 99%

Immunochemical and Biological Analysis of Allergenicity with Excretory-Secretory Products of <i>Anisakis simplex</i> Third Stage Larva

Kim¹,

Kim²,

Cho

et al. 2005

Int Arch Allergy Immunol

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Background:Anisakis simplex third stage larvae (L3) are parasites that frequently give rise to allergic responses. The larvae molt into fourth stage larvae (L4), and at each stage they produce L3-excretory-secretory products (L3-ESP) and L4-ESP, respectively, which are different in their main protein constituents. Although the allergenicity of L4-ESP has been investigated by several research groups, research on the allergenicity of L3-ESP has not been carried out by any researcher. In this investigation, the allergenicity and antigenicity of L3-ESP were investigated in comparison with L4-ESP, using rat sera. Methods: Rat sera were produced by L3 oral infection two times with a 9-week interval. Larvae ESP prepared by culture were concentrated and fractioned using lyophilizer and a centrifugal filter device, respectively. Immunochemical analysis was performed using both indirect ELISA and immunoblot. Biological allergenicity was analyzed by RBL-2H3 exocytosis. Results: With the indirect ELISA, the optical density (OD) value of the nonfractioned (NF)-L3ESP was only one third of that of the NF-L4ESP in both specific IgM and IgG. On measuring specific IgE, the OD of NF-L3ESP was less than one tenth of that of NF-L4ESP. In addition, neither antigen nor allergen was shown in NF-L3ESP, but it was shown in NF-L4ESP with immunoblot. However, the biological allergenicity of NF-L3ESP was comparable to that of NF-L4ESP. To demonstrate the presence of any allergen, L3-ESP was fractioned and found to carry twelve visualized allergen bands from 10 to 186 kDa by immunoblot. Conclusions: These results indicate that L3-ESP may include the important allergens necessary to induce the allergy by L3 oral infection, as compared to L4-ESP.

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Mackerel-induced urticaria and Anisakis

Cited by 121 publications

References 1 publication

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Opinion of the Scientific Panel on Dietetic products, nutrition and allergies [NDA] on a request from the Commission relating to the evaluation of allergenic foods for labelling purposes

Immunochemical and Biological Analysis of Allergenicity with Excretory-Secretory Products of <i>Anisakis simplex</i> Third Stage Larva

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