Machine perfusion and viability assessment of non–heart-beating donor kidneys—a single-centre result

Balupuri, S.; Mantle, D; Mohamed, Mostafa; Shenton, BK; Gok, MA; Soomro, NA; Manas, DM; Kirby, John A.; Talbot, David

doi:10.1016/s0041-1345(00)02455-6

Cited by 18 publications

(14 citation statements)

References 7 publications

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“…18,81,82 One found DGF with acute rejection predicted poor 5-year graft survival but when DGF was adjusted for acute rejection it was not associated with decreased graft survival. 83 The remaining 12 studies all found DGF to be significantly associated with graft loss. On balance, the published studies show that DGF is associated with higher rates of graft loss.…”

Section: Chaptermentioning

confidence: 99%

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

124

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email.Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAThe clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heartbeating and non-heart-beating donors This report should be referenced as follows:Wight J, Chilcott J, Holmes M, Brewer N. The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors. Health Technol Assess 2003;7(25). Health Technology Assessment is indexed in Criteria for inclusion in the HTA monograph seriesReports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search, appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. O2Objectives: To evaluate the clinical and costeffectiveness of machine perfusion (MP) compared to cold storage (CS), as a means of preserving kidneys prior to transplantation. Transplantation of kidneys from both heart-beating donors (HBDs) and non-heartbeating donors (NHBDs) is considered. Finally to review whether the use of MP can allow valid testing of kidney viability prior to transplantation. Data sources: Fifteen electronic bibliographic databases were searched. The reference lists of relevant articles and sponso...

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Section: Chaptermentioning

confidence: 99%

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

124

View full text Add to dashboard Cite

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“…However, many are simply mindful of the potential numerical superiority of uncontrolled DCDs over other donor groups (9). (10,11) (12) (13)(14)(15) …”

Section: Donation After Cardiac Death (Dcd) Kidneys Are Associated Wimentioning

confidence: 99%

“…As a result it is necessary to assess the extent of this injury prior to transplantation, in order to determine whether thresholds of viability have been breached (14,(26)(27)(28) (Figure 2). (Figure 3).…”

Section: Machine Perfusion and Viability Testingmentioning

confidence: 99%

Peritoneal Cooling May Provide Improved Protection for Uncontrolled Donors After Cardiac Death: An Exploratory Porcine Study

Navarro

Asher

Sohrabi

et al. 2009

American Journal of Transplantation

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Uncontrolled donation after cardiac death (DCD) renal transplantation relies on rapid establishment of organ preservation interventions. We have developed a model of the uncontrolled DCD, comparing current in situ perfusion (ISP) techniques with additional peritoneal cooling (PC). Ten pigs were killed and subjected to a 2 h ischemia period. The ISP group modeled current DCD protocols. The PC group (PC) modeled current protocols plus PC. Two animals were used as controls and subjected to 2 h of warm ischemia. Core renal temperature and microdialysis markers of ischemia were measured. Preservation interventions began at 30 min, with rapid laparotomy and kidney recovery performed at 2 h, prior to machine perfusion viability testing. The final mean renal temperature achieved in the ISP group was 26.3• C versus 16.9• C in the PC group (p = 0.0001). A significant cryopreservation benefit was suggested by lower peak microdialysate lactate and glycerol levels (ISP vs. PC, p = 0.0003 and 0.0008), and the superiority of the PC group viability criteria (p = 0.0147). This pilot study has demonstrated significant temperature, ischemia protection and viability assessment benefits with the use of supplementary PC. The data suggests a need for further research to determine the potential for reductions in the rates of ischemia-related clinical phenomena for uncontrolled DCDs.

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“…Perfusate enzyme levels (glutathione-s-transferases) and perfusion variables (eg. vascular resistance and flow) have been shown to be reasonably good surrogate markers of graft function after implantation [71,72].…”

Section: Energy Depletionmentioning

confidence: 99%

Preservation Solutions for Solid Organ Transplantation

Brook¹,

Talbot²

2006

MRMC

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Machine perfusion and viability assessment of non–heart-beating donor kidneys—a single-centre result

Cited by 18 publications

References 7 publications

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Peritoneal Cooling May Provide Improved Protection for Uncontrolled Donors After Cardiac Death: An Exploratory Porcine Study

Preservation Solutions for Solid Organ Transplantation

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