Machine Learning of ZnO Interaction with Immunoglobulins and Blood Proteins in Medicine

Osman, Nasreddin Abdel Qader; Al-Ziyadi, Shatha Hallal; Alazzam, Malik Bader; Alshawwa, Samar Zuhair; Rahman, Adnan

doi:10.1155/2022/4062974

“…The quantity and quality of a woman's ovarian follicular pool are thought to be bound up with her age and FSH [ 8 ], whereas according the recent research, the number of follicles is strongly bound up with AMH level [ 9 , 10 ]. Contrary to other hormonal markers of ovarian follicular state (FSH, E2, and inhibin B), AMH has no significant changes within and between menstrual cycles [ 11 , 12 ]. AMH has higher sensitivity (80% vs. 28.57%) and almost the same specificity (78.89% vs. 78.65%) in the diagnosis of POF in contrast to FSH.…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Anti-Mullerian Hormone in the Diagnosis of Ovarian Reserve Function in Patients with Premature Ovarian Insufficiency

Yan¹,

Zhang²,

Yu³

et al. 2022

BioMed Research International

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Objective. To explore the diagnostic value of serum anti-Mullerian hormone (AMH) for patients with premature ovarian insufficiency (POI) and premature ovarian failure (POF). Methods. Totally, 125 women with menstrual disorder treated in the Obstetrics and Gynecology Department of Ningbo Women & Children Hospital between January 2020 and December 2021 were enrolled. Among them, based on the follicle-stimulating hormone (FSH) level, 54 patients ( 25 IU / L < FSH ≤ 40 IU / L ) were assigned to the POI group, and 71 patients ( FSH > 40 IU / L ) were assigned to the POF group. In addition, 72 individuals who went physical examination in the hospital and showed normal menstrual cycle were selected as the control (CON) group. Serum AMH in each group was quantified via enzyme-linked immunosorbent assay (ELISA) and Beckman Coulter Access active immunoassay analyzer, and the levels of serum neutral hormones [luteinizing hormone (LH), FSH, as well as estradiol (E2)] in each group were detected through the electrochemiluminescence method. The difference between AMH level acquired by the latest automatic method and that acquired by the traditional manual ELISA was compared, and the correlation of serum AMH with sex hormones was analyzed. In addition, receiver-operating characteristic (ROC) curves were drawn for determining the diagnostic value of serum AHM for POI ad POF. Results. Beckman Coulter Access quantified AMH more accurately and fastly (Beckman Coulter Access: 35 minutes; manual quantification: 3-4 hours) and was more sensitive than ELISA, with a requirement to less serum. The levels of serum AMH and E2 in the POF group were 0.04 ± 0.10 ng/mL and 35.16 ± 53.06 ng/mL, respectively, which were notably lower than those in the POI group (( 0.69 ± 1.46 ) ng/mL and ( 3.96 ± 2.82 ) ng/mL) and CON group (( 76.31 ± 97.84 ) ng/mL and ( 113.19 ± 114.84 ) ng/mL). The LH and FSH levels in the POF group were 37.86 ± 19.44 IU/L and 75.05 ± 35.31 IU/L, which were higher than those in POI group (( 22.66 ± 26.15 ) IU/L and ( 11.30 ± 17.05 ) IU/L) and the CON group (( 29.81 ± 4.45 ) IU/L and ( 6.78 ± 3.45 ) IU/L) ( P < 0.05 ). The POI group showed a notably lower serum AMH level and notably higher LH and FSH levels than the CON group ( P < 0.05 ), and the POI group was similar to the CON group in the E2 level ( P > 0.05 ). Serum AMH showed a positive correlation with E2 ( r = 0.291 , P < 0.05 ) and a negative association with both FSH ( r = − 0.476 , P < 0.05 ) and LH ( r = − 0.143 , P < 0.1 ). The optimal cut-off value of serum AMH in predicting POI was 0.83 ng/mL, and the corresponding sensitivity and specificity were 95.8% and 85.2%. The optimal cut-off of serum AMH in predicting POF was 0.075 ng/mL, and the corresponding sensitivity and specificity were 81.7% and 94.4%. The area under ROC curve (AUC) of serum AMH + FSH in the diagnosis of POF was close to 1. Conclusion. Beckman Coulter Access AMH test is the latest automatic electrochemiluminescence sandwich immunoassay, with higher sensitivity and reproducibility than traditional manual ELISA and with ability to produce repeatable results. With the decline of ovarian function, the serum AMH of POI patients decreases gradually, and the serum AMH of POF patients decreases obviously, so serum AMH level has great value in predicting POI and POF and can be used as a sensitive index for early diagnosis of the two. Serum AMH combined with FSH can lift the diagnostic efficiency of POF.

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“…However, there was no significant relationship between having cardiovascular problems and the severity of the symptoms. On the other hand, some studies in other countries, for example, Korea, have shown that there is a strong association between cardiovascular risk factors and the severity of COVID-19 [14,15]. 4.3.…”

Section: Cardiac Diseasesmentioning

confidence: 96%

Clinical Characteristics and Risk Factors among Patients with Positive COVID-19 Test Admitted to ICU

Alanazi

¹

,

Alturki

²

,

Alosaimi

³

et al. 2022

BioMed Research International

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Background. Studies that show common characteristics among ICU-admitted patients due to COVID-19 are available on the net, but such studies in Saudi Arabia are limited. Methods. A descriptive cross-sectional study establishing common comorbidities and risk factors among critically ill patients who tested positive for COVID-19 at the National Guard Hospital from March 2, 2020, to March 20, 2021. The data were obtained from the BEST Care System of King Abdulaziz Medical City, computed, and analyzed using SPSS. Results. Three hundred eighty-five COVID-19 patients admitted to the intensive care unit (ICU) were included in this study. The mean age was 60.85 ± 20.46 , 60.85% were males, and 39.2% were females. There was statistically significant positive relationship between severity of the symptoms and age ( P = 0.002 ). The mean duration of hospital stay in the sample was 21.85 ± 28.47 . More than one-third (37.4%) of cases admitted to the hospital died while about two-thirds of the cases were discharged after complete recovery. Two hundred ninety (75.3%) of the patients who were admitted to the National Guard Health Affairs (Riyadh, Saudi Arabia) had respiratory disease. Two hundred twelve patients (55.1%) had diabetes mellitus, while the number of hypertensive patients was 203 (52.7%). There was a significant positive relation among patients with gastrointestinal tract infection (GIT) risk factors and the severity of the symptoms of COVID-19 ( P = 0.000 ). In addition, there was a strong significant relation between hypertension patients and the severity of the COVID-19 symptoms ( P = 0.017 ). Conclusion. COVID-19 patients who have GIT and hypertension have been found to be at an increased risk of COVID-19 symptom severity. Old age was also found to have an increased risk for COVID-19 symptom severity.

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“…Using a set of completely abnormal images, Vincent et al reported that 35% of EPs made mistakes [19]. Nevertheless, clinical outcomes are rarely affected by missed diagnoses during the time between initial interpretation and radiological evaluation [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Brain Computed Tomography Diagnosis by Emergency Medicine Physicians

Aseri

¹

,

Aqeel

²

,

Aldawood

³

et al. 2022

Computational Intelligence and Neuroscience

0

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Objectives. The objective of this study is to prospectively analyze emergency physicians’ (EP’s) abilities to interpret noncontrast computed tomography (NCCT) brain images in a blinded fashion and assess whether they can make medical decisions solely based on their interpretations. Methods. A cross-sectional study was conducted at the emergency department (ED), King Saud University Medical City (KSU-MC), Saudi Arabia, over a period of one year, from May 2014 to May 2015. Any patient who underwent plain brain NCCT during the study period in our ED was included in this study. An independent attending neuroradiologist compared the EP’s interpretations with the official final reports dictated by an on-call radiologist. Results. A brain NCCT prospective chart audit of 1,524 patients was interpreted by ED physicians (EP) at KSU-MC from 2014–2015. The ages of patients were between 14 and 107 years, and the mean ± SD age was 45.6 ± 22.1 years. Radiological brain lesions were confirmed by EPs and radiology physicians in 230 (15.09) and 239 (15.68) patients, respectively, out of which concordance was observed in 170 (71.13) cases, with a kappa value of r = 0.675. Normal, chronic, and nil acute reports were made by EPs and radiology physicians for 1,295 (84.97) patients and 1,285 (84.32) patients, respectively, out of which concordance was observed in 1,225 (95.33) cases, with a kappa value of r = 0.672. The study results demonstrated that the overall agreement between EPs and radiologist specialists was 91.6, with a kappa value of .675 ( p < 0.001 ). Conclusion. Emergency physicians are moderately accurate at interpreting brain NCCT compared to radiologists. More research is needed to discover the most cost-effective technique for reducing the number of significant misinterpretations.

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Machine Learning of ZnO Interaction with Immunoglobulins and Blood Proteins in Medicine

Cited by 4 publications

References 28 publications

Study of Serum Anti-Mullerian Hormone in the Diagnosis of Ovarian Reserve Function in Patients with Premature Ovarian Insufficiency

Study of Serum Anti-Mullerian Hormone in the Diagnosis of Ovarian Reserve Function in Patients with Premature Ovarian Insufficiency

Clinical Characteristics and Risk Factors among Patients with Positive COVID-19 Test Admitted to ICU

Accuracy of Brain Computed Tomography Diagnosis by Emergency Medicine Physicians

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