M2 macrophages infusion ameliorates obesity and insulin resistance by remodeling inflammatory/macrophages' homeostasis in obese mice

Zhang, Qi; Hao, Haojie; Xie, Zongyan; Cheng, Yu; Yin, Yaqi; Xie, Min; Huang, Hong; Gao, Jian; Liu, Hongyu; Tong, Chuan; Zang, Li; Mu, Yiming; Han, Weidong

doi:10.1016/j.mce.2017.01.005

Cited by 15 publications

(18 citation statements)

References 29 publications

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“…In non-obese subjects, adipocytes release higher levels of adiponectin that improves insulin sensitivity and enhances M2 macrophage polarization [15]. The density of M2 macrophages is lower compared to M1 macrophages in obese patients [16] as a result of imbalance in CCR2/CCL2 and CCR5 axis. The imbalance in obese patients due to pro-inflammatory cytokines influences the M1/M2 polarization.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

et al. 2017

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BackgroundTREM-1 acts as an amplifier of inflammation expressed on macrophages. The objective of this study was to evaluate the relationship between TREM-1 and macrophage polarization, and association of TREM-1 and M1 macrophage polarization with insulin resistance (IR) in obese population compared to non-obese population.MethodsWe enrolled 38 patients after obtaining IRB approval for this study. We evaluated the mRNA and protein expression levels of general macrophage marker (CD68), M1 marker (CD86, CCR7, iNOS, IFNγ, TNF-α and IL-6,), M2 marker (CD206, CD163, IL-10, IL-4) and chemokine axis (MCP-1, CCR2 and CCR5) along with TREM-1 and TREM-2 in omentum fat, subcutaneous fat, and liver biopsy tissues of non-obese (N = 5), obese non-diabetics, (N = 16) and obese diabetics (N = 17).ResultsThe results of our study showed over-expression of TREM-1, M1 markers and down-regulation of TREM-2 and M2 markers in the omentum, subcutaneous and liver biopsies of obese patients (diabetics and non-diabetics) compared to non-obese patients. Overall, the obese diabetic group showed a significant (p < 0.05) higher number of patients with over expression of M1 markers (TREM-1, CD68, CD86, CCR-7, iNOS, IFN-γ, TNF-α, IL-6, MCP-1, CCR-2 and CCR-5) and down-regulation of M2 markers (CD206, CD163 and IL-4) in liver biopsy compared to obese non-diabetics.ConclusionsTREM-1 expression is significantly increased along with the M1 markers in liver biopsy of obese diabetic (17/17) and obese non-diabetic patients (9/16). Our data suggests that TREM-1 overexpression and M1 macrophage polarization are associated with obesity-induced IR.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

et al. 2017

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“…Most importantly, these mice also displayed a higher polarization of adipose tissue‐resident macrophages to a pro‐resolution M2 profile. Previous studies have shown an inverse relationship between obesity/insulin resistance and adipose tissue M2 macrophage content, whereas strategies that increase adipose tissue M2 macrophage content such as infusion of either M2 macrophages or its inducer IL‐4 were shown to protect mice from diet‐induced obesity and insulin resistance . Importantly, the increase in energy expenditure displayed by mice transplanted with Tsc1 ‐deficient myeloid cells was not related to changes in spontaneous locomotor activity, but occurred in association with a reduction in BAT mass and a trend ( p = 0.06) for an increase in BAT, but not white adipose tissue, UCP1 mRNA content, suggesting the possible involvement of BAT nonshivering thermogenesis as underlying cause.…”

Section: Discussionmentioning

confidence: 84%

Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet‐Induced Obesity

Paschoal

Belchior

Amano

et al. 2018

Molecular Nutrition Food Res

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“…Lastly, pro-inflammatory TNFα was reported to potently disrupt the insulin signaling cascade [81]. In this study, the M2 infusion group demonstrated amelioration in insulin resistance and significantly reduced lipid metabolism in triglycerides, high density lipoprotein, and low density lipoprotein cholesterol [40]. Hyperglycemia is described as a biochemical feature of diabetes, and unfortunately, high glucose levels have been reported to increase ROS-dependent pro-inflammatory activation.…”

Section: Role Of Macrophages In Obesity and Metabolic Diseasesmentioning

confidence: 98%

“…The findings of Zhang [40] highlighted the therapeutic effect by remodeling homeostasis of macrophages. High fat diet (HFD)-induced obese mice were administrated with IL-4, polarized M φ and M2 macrophages given intraperitoneally and through the tail veil, respectively.…”

Section: Role Of Macrophages In Obesity and Metabolic Diseasesmentioning

confidence: 99%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

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M2 macrophages infusion ameliorates obesity and insulin resistance by remodeling inflammatory/macrophages' homeostasis in obese mice

Cited by 15 publications

References 29 publications

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet‐Induced Obesity

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

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