M1976 GERD, Barrett's Esophagus and Helicobacter pylori Infection

Meng, Xiangwen; Scheer, Marc A.; Tsang, Tat-Kin

doi:10.1016/s0016-5085(08)62069-7

Cited by 3 publications

(9 citation statements)

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“…Our search strategy initially identified 1705 potential studies. Removal of duplicates was followed by screening first the titles, and then the abstracts, leaving 96 studies for full‐text review, including 8 additional studies identified in the reference lists of the primary eligible studies . Thirteen studies were excluded, as they did not provide sufficient data (reasons for exclusion detailed in Appendix ).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies were excluded, as they did not provide sufficient data (reasons for exclusion detailed in Appendix ). Data were extracted from 83 studies; however, 11 of these studies had to be excluded from the statistical analysis as they contained data from same populations already described in other articles . Our final statistical analysis included 72 studies.…”

Section: Resultsmentioning

confidence: 99%

“…There were 4 additional studies reporting the prevalence of CagA‐positive HPI in relation to BE, in addition to the studies identified by Fischbach et al which included results from 7 studies. In total, 11 studies were included in the subgroup analysis . A further study from Abouda et al in 2003 reported data on H. pylori strain positive for both CagA and VacA and not CagA strains only.…”

Section: Resultsmentioning

confidence: 99%

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Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

et al. 2018

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IntroductionThe prevalence of Helicobacter pylori infection (HPI) has been decreasing in developed countries, with an increasing prevalence of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) at the same time. The aim of our meta‐analysis was to quantify the risk of BE in the context of HPI.MethodsA systematic search was conducted in 3 databases for studies on BE with data on prevalence of HPI from inception until December 2016. Odds ratios for BE in HPI were calculated by the random effects model with subgroup analyses for geographical location, presence of dysplasia in BE, and length of the BE segment.ResultsSeventy‐two studies were included in the meta‐analysis, including 84 717 BE cases and 390 749 controls. The overall analysis showed that HPI reduces the risk of BE; OR = 0.68 (95% CI: 0.58‐0.79, P < .001). Subgroup analyses revealed risk reduction in Asia OR = 0.53 (95% CI: 0.33‐0.84, P = .007), Australia OR = 0.56 (95% CI: 0.39‐0.80, P = .002), Europe OR = 0.77 (95% CI: 0.60‐0.98, P = .035), and North‐America OR = 0.59 (95% CI: 0.47‐0.74, P < .001). The risk was significantly reduced for dysplastic BE, OR = 0.37 (95% CI: 0.26‐0.51, P < .001) for non‐dysplastic BE, OR = 0.51 (95% CI: 0.35‐0.75, P = .001), and for long segment BE, OR = 0.25 (95% CI: 0.11‐0.59, P = .001) in case of HPI.ConclusionsThis extensive meta‐analysis provides additional evidence that HPI is associated with reduced risk of BE. Subgroup analyses confirmed that this risk reduction is independent of geographical location. HPI is associated with significantly lower risk of dysplastic, non‐dysplastic, and long segment BE.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

et al. 2018

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“…We conducted a meta-analysis to summarize the effect that various factors have on Barrett's esophagus [4,[12][13][14][15][16][17][18][19]. However, the study presented here focuses on the analyses examining the effect of H. pylori on Barrett's esophagus.…”

Section: Methodsmentioning

confidence: 99%

The Association Between Barrett’s Esophagus and Helicobacter pylori Infection: A Meta‐Analysis

et al. 2012

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Objective The effect of Helicobacter pylori on Barrett’s esophagus is poorly understood. We conducted a meta-analysis to summarize the existing literature examining the effect that H pylori has on Barrett’s esophagus. Design We performed a comprehensive search to identify studies pertaining to the association between H pylori and Barrett’s esophagus. We conducted meta-regression analyses to identify sources of variation in the effect of H pylori on Barrett’s esophagus. Results Our analysis included a total of 49 studies that examined the effect of H pylori on Barrett’s esophagus and 7 studies that examined the effect of cag A positivity on Barrett’s esophagus. Overall, H pylori, and even more so cag A, tended to be protective for Barrett’s esophagus in most studies; however there was obvious heterogeneity across studies. The effect of H pylori on Barrett’s esophagus varied by geographic location and in the presence of selection and information biases. Only 4 studies were found without obvious selection and information bias, and these showed a protective effect of H pylori on Barrett’s esophagus (Relative Risk = 0.46 [95% CI: 0.35, 0.60]). Conclusions Estimates for the effect of H pylori on Barrett’s esophagus were heterogeneous across studies. We identified selection and information bias as potential sources of this heterogeneity. Few studies without obvious selection and information bias have been conducted to examine the effect of H pylori on Barrett’s esophagus, but in these, H pylori infection is associated with a reduced risk of Barrett’s esophagus.

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“…The relationship between H.pylori and BE development seems somewhat complicated. In the literature, there are studies that reach different results on this issue; in addition to the studies reporting that the presence of H.pylori is a risk factor for BE development, there are studies reporting that it does not influence the development of BE or it prevents BE development (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). In the study by Vaezi et al (29), it was found that being infected with H.pylori had a protective effect for development of BE and its malignant complications.…”

Section: Does the Presence Of Helicobacter Pylori Affect The Frequencmentioning

confidence: 99%

Gastroesophageal reflux disease and the relationship with Helicobacter pylori

Mungan

Simsek

2017

Turk J Gastroenterol

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M1976 GERD, Barrett's Esophagus and Helicobacter pylori Infection

Cited by 3 publications

References 0 publications

Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

The Association Between Barrett’s Esophagus and Helicobacter pylori Infection: A Meta‐Analysis

Gastroesophageal reflux disease and the relationship with Helicobacter pylori

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