<i>Helicobacter pylori</i> infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

Erőss, Bálint; Farkas, Nelli; Vincze, Áron; Tinusz, Benedek; Szekeres, L.; Garami, András; Balaskó, Márta; Patrícia, Silvia; Czopf, László; Alizadeh, Hussain; Rakonczay, Zoltán; Habon, Tamás

doi:10.1111/hel.12504

Cited by 62 publications

(54 citation statements)

References 102 publications

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“…There are various potential explanations for the association between Barrett's esophagus and colorectal polyps. Although the mechanisms remain unclear, patients with Barrett's esophagus are more likely to have some of the same risk factors as patients with colorectal polyps, including older age, male sex, alcohol drinking, smoking, and obesity . In the present study, the patients with colorectal polyps had risk factors including older age, male sex, obesity, smoking, and alcohol drinking, which overlap the risk factors for Barrett's esophagus.…”

Section: Discussionmentioning

confidence: 56%

“…First, selection bias might have been present because patients who underwent CS for cancer screening were included, while patients who received the surgical operation for the colorectal cancer was excluded. Second, some information related to acid secretion that may affect Barrett's esophagus was not analyzed; there was a shortage of data regarding H. pylori infection . Third, the relationship between the length of Barrett's esophagus and colorectal polyps was not evaluated because there were too few cases of LSBE in this study.…”

Section: Discussionmentioning

confidence: 99%

“…The risk factors for Barrett's esophagus, mainly evaluated in the long‐segment Barrett's esophagus (LSBE), include older age, male sex, smoking, obesity, high intake of red and/or processed meat, reflux esophagitis, and hiatal herniation. Helicobacter pylori infection is associated with a decreased risk . These studies indicate that Barrett's esophagus and colorectal polyps have several overlapping risk factors …”

Section: Introductionmentioning

confidence: 96%

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Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Takedomi

Tsuruoka

Takamori

et al. 2019

J of Gastro and Hepatol

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Background and Aim Barrett's esophagus and colorectal polyps have several overlapping risk factors. Whereas several reports in Western countries have indicated a close relationship between Barrett's esophagus and colorectal polyps, the relationship between these two diseases remains unclear in Japan. This study was performed to determine whether the prevalence of Barrett's esophagus is related to that of colorectal polyps in Japanese patients. Methods The present retrospective chart review included 1582 Japanese patients who underwent both total colonoscopy and esophagogastroduodenoscopy from January 2010 to December 2016. The data on colorectal polyps and Barrett's esophagus were obtained from the endoscopic findings. The medical record of each patient was checked for age, sex, body mass index, smoking, alcohol drinking, use of acid suppression agents, and comorbidities including a history of diabetes, ischemic heart disease, gastroesophageal reflux disease, hiatal hernia, and Helicobacter pylori infection. Results Colorectal polyps were detected in 789 of the 1582 patients (49.9%). Barrett's esophagus was detected in 233 patients (14.7%), and most cases of Barrett's esophagus (n = 229) were classified as short‐segment Barrett's esophagus. Colorectal polyps were more frequent in patients with than without Barrett's esophagus (odds ratio, 1.79; 95% confidence interval, 1.31–2.46; P < 0.001). In addition to Barrett's esophagus, the data indicated that old age, male sex, obesity, smoking, alcohol drinking, diabetes mellitus, and ischemic heart disease were independent risk factors for colorectal polyps. Conclusions The present study revealed the correlation between the prevalence of Barrett's esophagus and colorectal polyps in Japanese patients.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Takedomi

Tsuruoka

Takamori

et al. 2019

J of Gastro and Hepatol

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“…We additionally controlled our data for H. pylori , with no change in association between OSA and BE. Furthermore, in recent studies, H. pylori 's role in BE, if at all any, has been observed to be mostly protective …”

Section: Discussionmentioning

confidence: 99%

Independent association of obstructive sleep apnea with Barrett's esophagus

Hadi

Khan

Naqvi

et al. 2019

J of Gastro and Hepatol

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Background and Aim Current guidelines suggest screening at‐risk groups of patients for Barrett's esophagus (BE), a precursor to esophageal cancer. Although BE and obstructive sleep apnea (OSA) have common risk factors, including elevated body mass index and gastroesophageal reflux disease (GERD), the relationship between these two conditions has not been well established. Methods Retrospectively, all patients who had undergone a polysomnography and esophagogastroduodenoscopy at West Virginia University Hospital from 2013 to 2018 were identified and divided into groups on the basis of the presence or absence of OSA. Clinical course and procedure reports were reviewed to identify relevant variables. Results One thousand ninety‐one patients met inclusion criteria; 60.9% were female, and mean age of participants was 53.5 years. Univariate analysis revealed that male gender, age, diagnosis of OSA, severity of OSA, and a clinical diagnosis of GERD were associated with BE (P values < 0.05). Multiple logistic regression incorporating age, sex, clinical diagnosis of GERD, smoking history, body mass index, Helicobacter pylori status, and presence of hiatal hernia was utilized. Patients with OSA had an increased risk of BE than had those without OSA (P < 0.001, odds ratio 3.26 [1.72–6.85]). The risk increased with increasing severity of OSA, categorized in apnea–hypopnea index increments of 10. Conclusion Obstructive sleep apnea is associated with BE, a relationship that is independent of other known risk factors. Additionally, this risk increases with increasing severity of OSA. Future efforts should determine if patients with severe OSA need to be screened for BE due to its potential for causing esophageal cancer.

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“…1 Our meta-analysis concluded that H. pylori infection (HPI) reduces the risk of Barrett's esophagus (BE), dysplasia and adenocarcinoma developing in BE. 1 Our meta-analysis concluded that H. pylori infection (HPI) reduces the risk of Barrett's esophagus (BE), dysplasia and adenocarcinoma developing in BE.…”

Section: Dear Editormentioning

confidence: 99%

Reply: Does Helicobacter pylori infection increase the risk of Barrett's esophagus and esophageal adenocarcinoma?

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Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta‐analysis and systematic review

Cited by 62 publications

References 102 publications

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Correlation of Barrett's esophagus with colorectal polyps in Japanese patients: A retrospective chart review

Independent association of obstructive sleep apnea with Barrett's esophagus

Reply: Does Helicobacter pylori infection increase the risk of Barrett's esophagus and esophageal adenocarcinoma?

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