M1155 Prevalence of Inflammatory Bowel Disease in a University Hospital Health Maintenance Organization

Sobrero, Maria J.; Varela, Emilio; González, María Laura; Piccioni, Héctor L.; Bohbouth, Graciela Estela; Orsi, Marina; D’Agostino, Daniel; Dávolos, Jorge; Paula, Juan A. De

doi:10.1016/s0016-5085(09)61658-9

Cited by 7 publications

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“… 27 , 28 In line with this, the highest proportion of patients (43%) had pancolitis in a study in Argentina. 10 Proximal extension developed in 17.4% of patients in Montevideo, Uruguay. 36 Disease severity was only reported in 3 studies from Brazil, with moderate to severe UC accounting for 45.9–73.0% of all cases ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 98%

“…The mean age at disease onset/diagnosis ranged from 31.0 years in Puerto Rico to 41.7 years in Uruguay. 33 , 35 The gender of patients with UC was reported in the majority of studies, with the proportion of males ranging from 27.4% in Mato Grosso do Sul, Brazil to 46.4% in Argentina, 10 , 19 highlighting that UC is more prevalent in females in Latin America. The mean disease duration was 9.3 years in Puerto Rico and 7.6 years in Bahia, Brazil.…”

Section: Resultsmentioning

confidence: 99%

“…One hospital-based, multicentre study identified 38 cases of UC in Argentina between 1987 and 1993, with an incidence of 2.2/100,000 person-years, 9 and a study using health maintenance organisation records identified 112 cases of UC in Argentina, with a prevalence of 76.1/100,000. 10 …”

Section: Resultsmentioning

confidence: 99%

“…In 11 studies, the greatest proportion of patients had extensive (pancolitis). 10 , 17 , 21 – 24 , 27 – 30 , 33 In a nationwide study in Mexico, which separated UC extension by age group, pancolitis was the most frequent extension of UC in children (64.4%), adult (62.2%) and elderly (57.7%) patients; distal/proctosigmoiditis was the second most frequent extension in children (22.2%), adult (24.8%) and elderly (26.8%) patients; and left-sided colitis was the least frequent extension in children (13.3%), adult (13.0%) and elderly (15.6%) patients. 27 , 28 In line with this, the highest proportion of patients (43%) had pancolitis in a study in Argentina.…”

Section: Resultsmentioning

confidence: 99%

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Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

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The incidence and prevalence of ulcerative colitis (UC) has been reported to be rising in newly industrialised regions, such as Latin America. Here, we review data from published studies reporting demographics and clinical aspects of UC in Latin America to further understand epidemiology and disease burden. The incidence and prevalence of UC in Latin America varied between regions and studies, ranging between 0.04 to 8.00/100,000 and 0.23 to 76.1/100,000, respectively, and generally increased over the period from 1986 to 2015. The majority of patients with UC were female (53.6–72.6%) and urban residents (77.8–97.4%). Extraintestinal manifestations were reported in approximately 26–89.4% of patients. Use of biologic therapies was generally low (0.8–16.2%), with the exception of Mato Grosso do Sul, Brazil, with a greater proportion of patients tending to receive 5-aminosalicylates, immunosuppressants or corticosteroids; colectomy rates varied between studies (1.5–22%). A high proportion of patients had moderate to severe UC (45.9–73.0%) and, in 11 of 19 studies, the greatest proportion of patients had extensive disease (pancolitis). Colorectal cancer (0–1.7%) and mortality rates (0–7.6%) were low. This evaluation of published studies may influence therapeutic approaches and the development of strategies to improve healthcare access and patient outcomes, although further high-quality studies are required in patients with UC in Latin America.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

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“…Panama, Uruguay, Argentina, Mexico, Colombia and Brazil have reported increased UC rates in their population studies. [ 15 , 17 , 31 – 33 ] The incidence of CD in Brazil has also risen sharply from 0.68 in 1991–1995 to 5.48 in 2015.15,18 Similarly, the incidence of both CD and UC in Puerto Rico has more than doubled between 1996 and 2000 (3.07–7.74). [ 13 ] Our UC incidence and prevalence data mirror those reported in these other Latin American studies.…”

Section: Discussionmentioning

confidence: 99%

Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients

et al. 2021

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The incidence of inflammatory bowel disease (IBD) is on the rise in Latin America. The aims of this study were to examine epidemiologic trends of IBD in Colombia by demographics, region, urbanicity, and to describe the IBD phenotype in a large well-characterized Colombian cohort. We used a national database of 33 million adults encompassing 97.6% of the Colombian population in order to obtain epidemiologic trends of IBD using International Classification of Diseases 10codes for adults with ulcerative colitis (UC) and Crohn disease (CD). We calculated the incidence and prevalence of UC and CD from 2010–2017 and examined epidemiologic trends by urbanicity, demographics, and region. We then examined the IBD phenotype (using Montreal Classification), prevalence of IBD-related surgeries, and types of IBD-medications prescribed to adult patients attending a regional IBD clinic in Medellin, Colombia between 2001 and 2017. The incidence of UC increased from 5.59/100,000 in 2010 to 6.3/100,000 in 2017 (relative risk [RR] 1.12, confidence interval (CI) (1.09–1.18), P < .0001). While CD incidence did not increase, the prevalence increased within this period. The Andes region had the highest incidence of IBD (5.56/100,000 in 2017). IBD was seen less in rural regions in Colombia (RR=.95, CI (0.92–0.97), p < .01). An increased risk of IBD was present in women, even after adjusting for age and diagnosis year (RR 1.06 (1.02–1.08), P = .0003). The highest IBD risk occurred in patients 40 to 59 years of age. In the clinic cohort, there were 649 IBD patients: 73.7% UC and 24.5% CD. Mean age of diagnosis in CD was 41.0 years and 39.9 years in UC. UC patients developed mostly pancolitis (43%). CD patients developed mostly ileocolonic disease and greater than a third of patients had an inflammatory, non-fistulizing phenotype (37.7%). A total of 16.7% of CD patients had perianal disease. CD patients received more biologics than UC patients (odds ratio: 3.20, 95% CI 2.19–4.69 P < .001). Using both a national representative sample and a regional clinic cohort, we find that UC is more common in Colombia and is on the rise in urban regions; especially occurring in an older age cohort when compared to Western countries. Future studies are warranted to understand evolving environmental factors explaining this rise.

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Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review

Kotze

Underwood

Damião

et al. 2020

Clinical Gastroenterology and Hepatology

136

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BACKGROUND & AIMS:The incidence of inflammatory bowel diseases (IBD) is increasing in Latin America. We performed a systematic review to identify clinical and epidemiologic features of IBD in Latin America (including Mexico, Central America, and South America) and the Caribbean. METHODS:We searched MEDLINE, EMBASE, and SciELO databases for clinical or epidemiologic studies of Crohn's disease (CD) or ulcerative colitis (UC) from Latin American and Caribbean countries and territories that reported incidence, prevalence, ratio of UC:CD, IBD phenotype, and treatment, through September 12, 2018. Data were extracted from 61 articles for analysis. RESULTS:The incidence and prevalence of IBD have been steadily increasing in Latin America and the Caribbean. The incidence of CD in Brazil increased from 0.08 per 100,000 person-years in 1988 to 0.68 per 100,000 person-years in 1991-1995 to 5.5 per 100,000 person-years in 2015. The highest reported prevalence of IBD was in Argentina, in 2007, at 15 and 82 per 100,000 personyears for CD and UC, respectively. The ratio of UC:CD exceeded 1 in all regions throughout Latin America and the Caribbean with the exception of Brazil. Treatment with tumor necrosis factor antagonists increased steadily for patients with CD (43.4% of all patients in Brazil were treated in 2014) but less so for patients with UC (4.5% of all patients were treated in 2014). Surgery for IBD decreased with time. In Chile, surgeries were performed on 57.0% of patients with CD and 18.0% of patients with UC during the period of 1990-2002; these values decreased to 38.0% and 5.0%, respectively, during the period of 2012-2015. In Peru, 6.9% of patients with UC received colectomies in the period of 2001-2003 and 6.2% in 2004-2014. CONCLUSIONS:In a systematic review, we found the incidence of IBD to be increasing throughout Latin America and the Caribbean. Population-based epidemiology studies are needed to evaluate the increase in IBD in these regions, which differ from other global regions in climate, culture, demographics, diet, healthcare delivery and infrastructure, and socioeconomic status.

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M1155 Prevalence of Inflammatory Bowel Disease in a University Hospital Health Maintenance Organization

Cited by 7 publications

References 0 publications

Review of the epidemiology and burden of ulcerative colitis in Latin America

Review of the epidemiology and burden of ulcerative colitis in Latin America

Trends in the epidemiology of inflammatory bowel disease in Colombia by demographics and region using a nationally representative claims database and characterization of inflammatory bowel disease phenotype in a case series of Colombian patients

Progression of Inflammatory Bowel Diseases Throughout Latin America and the Caribbean: A Systematic Review

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