M1/M2 polarization in major depressive disorder: Disentangling state from trait effects in an individualized cell-culture-based approach

Cosma, Nicoleta Carmen; Üsekes, B.; Otto, Lisa Rebecca; Gerike, Susanna; Heuser, Isabella; Regen, Francesca; Hellmann-Regen, Julian

doi:10.1016/j.bbi.2021.02.009

Cited by 22 publications

(29 citation statements)

References 66 publications

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“…Accumulating evidence has demonstrated the significance of an abnormal inflammatory response in the development of MDD ( 18 , 75 ). As previously reported, the proportions of Tregs, monocytes, and M0 macrophages in patients with MDD were significantly higher than those in controls, which is consistent with our findings ( 76 – 78 ). In addition, we discovered that ERS-related hub genes, such as CASP1 and MAPK14, were positively associated with immune cells, specifically neutrophils.…”

Section: Discussionsupporting

confidence: 94%

Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder

et al. 2022

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BackgroundMajor depressive disorder (MDD) is a life-threatening, debilitating mental health condition. An important factor in the development of depression is endoplasmic reticulum stress (ERS). However, their roles in MDD have not yet been established. The goal of this study was to examine ERS and its underlying molecular mechanisms in MDD.MethodsWe used data from two microarray datasets (GSE98793 and GSE39653) and the GeneCards database to examine the reticulum stress-related differentially expressed genes (ERSR-DEGs) associated with MDD. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and Gene Set Variation Analysis (GSVA) were used to further investigate the function and mechanism of ERS in MDD. Moreover, we constructed protein-protein interaction (PPI) networks to identify hub genes as well as the regulatory network of microRNAs (miRNAs), transcription factors (TFs), and potential drugs related to ERSR-DEGs. CIBERSORT was then used to evaluate the immune activity of MDD samples and conduct a correlation analysis between the hub genes and immune cells.ResultsIn total, 37 ERSR-DEGs and five hub genes were identified (NCF1, MAPK14, CASP1, CYBA, and TNF). Functional enrichment analysis revealed that ERSR-DEGs were predominantly enriched in inflammation-and immunity-related pathways, such as tumor necrosis factor signaling, NF-κB signaling, and Toll-like receptor signaling pathways. Additionally, 179 miRNAs, 25 TFs, and 15 potential drugs were tested for their interactions with the ERSR-DEGs. CIBERSORT found high proportions of Tregs, monocytes, and macrophages M0 in the MDD samples. Among these, hub genes showed a significant correlation with immune cell infiltration in patients with MDD.ConclusionsNCF1, MAPK14, CASP1, CYBA, and TNF are potential ERS-related biomarkers for the diagnosis of MDD. Our research has revealed a significant correlation between immune cells and ERS-related genes with MDD. Not only did our study contribute to a better understanding of the regulatory mechanisms of ERS in underlying MDD pathology, but it also established a paradigm for future studies on ERS.

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Section: Discussionsupporting

confidence: 94%

Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder

et al. 2022

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“…This shows that immune remodeling can be one of mediators of emotion-induced AF. In another study, major depressive disorder-derived monocytes displayed higher proportion of M1 polarization phenotype under standard culture conditions, but, higher M2 polarization when co-stimulated with autologous sera (Cosma et al, 2021). This fully reflects the plasticity of immune cells and potential value of immune regulation.…”

Section: Immune Remodeling and Neural Remodelingmentioning

confidence: 87%

Immune remodeling and atrial fibrillation

et al. 2022

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Atrial fibrillation (AF) is a highly prevalent arrhythmia that causes high morbidity and mortality. However, the underlying mechanism of AF has not been fully elucidated. Recent research has suggested that, during AF, the immune system changes considerably and interacts with the environment and cells involved in the initiation and maintenance of AF. This may provide a new direction for research and therapeutic strategies for AF. In this review, we elaborate the concept of immune remodeling based on available data in AF. Then, we highlight the complex relationships between immune remodeling and atrial electrical, structural and neural remodeling while also pointing out some research gaps in these field. Finally, we discuss several potential immunomodulatory treatments for AF. Although the heterogeneity of existing evidence makes it ambiguous to extrapolate immunomodulatory treatments for AF into the clinical practice, immune remodeling is still an evolving concept in AF pathophysiology and further studies within this field are likely to provide effective therapies for AF.

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Section: Discussionmentioning

confidence: 99%

“…Combined with relevant literature, the polarization direction of microglia M1/M2 is closely related to the treatment of ischemic PSD, 22,25 Sirt1 can inhibit the expression of IL-1, IL-6, TNF-α pro-inflammatory factors, and Sirt1/NF-The κB pathway also plays an important role in regulating microglial M1/M2 polarization. [26][27][28] In conclusion, this study analyzed depression and stroke separately through bioinformatics analysis, combined with existing post-stroke depression studies, and identified 5 disease-related genes ("NRBP1", "SIRT1", "BDNF" ', "MAPK3", "CREB1".) and PSD-related pathways, the selected biomarkers SIRT1 and P65 were validated by QRT-PCR in plasma samples.…”

Section: Discussionmentioning

confidence: 99%

Study on Biomarkers Related to the Treatment of Post-Stroke Depression and Alternative Medical Treatment Methods

Li¹,

Ding²,

Yang³

et al. 2022

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Purpose PSD is a syndrome that occurs after a stroke, which manifests as a series of depressive symptoms and corresponding physiological symptoms. Relevant studies have shown that the drug therapy is often accompanied by drug side effects and patient resistance. Acupuncture has attracted attention as a treatment method without adverse reactions of patients. The purpose of this study was to investigate the possible mechanism of action of acupuncture in PSD. Patients and Methods Download depression and stroke datasets from public databases. Bioinformatics methods were used to analyze the key gene targets related to stroke and depression. Functional enrichment analysis assesses important pathways. Further screen PSD-related biological pathways and genes. After the experimental model was established, the expression differences of key genes and related pathways were compared between the model group and the control group through acupuncture treatment and qPCR verification. Results Depression and stroke-related genes were obtained by bioinformatics methods, and then important biological processes and biological pathways related to depression and stroke were analyzed by GO and KEGG. And further screen out the disease targets closely related to PSD. In the follow-up animal experiments, we confirmed that acupuncture can intervene on these key pathways and targets, and then play a role in the targeted therapy of diseases. Conclusion The results of this study show that five genes (“NRBP1”, “SIRT1”, “BDNF”, “MAPK3”, “CREB1”.) and key biological pathways such as NFkB, PI3K/AKT activation, and MAPK are the keys to the occurrence and development of PSD biomarkers, which can also be therapeutically intervened by acupuncture.

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M1/M2 polarization in major depressive disorder: Disentangling state from trait effects in an individualized cell-culture-based approach

Cited by 22 publications

References 66 publications

Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder

Comprehensive analysis of endoplasmic reticulum stress and immune infiltration in major depressive disorder

Immune remodeling and atrial fibrillation

Study on Biomarkers Related to the Treatment of Post-Stroke Depression and Alternative Medical Treatment Methods

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