LysR-type transcriptional regulators: state of the art

The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa

“…The DBD specifically binds to the promoter region of target genes, and the EBD interacts with effectors to regulate target gene expression. LysR family transcriptional regulators lay a role in various physiological processes such as central carbon metabolism, amino acid biosynthesis, cell division, and secondary metabolite production [ 15 ]. Notably, multiple amino acid sequence alignment showed that the DBD of ORF-L16 shares 56 % identity with the DBDs of LysR family transcriptional regulators that have complete crystal structures ( Fig.…”

The LysR‐type transcriptional regulator LelA co‐regulates various effectors in different Legionella species

“…LysR-type transcriptional regulators (LTTRs) are abundant prokaryotic DNA-binding proteins (Baugh et al, 2023;Maddocks & Oyston, 2008;Mayo-Perez et al, 2023). The basic structure of the LTTR family members includes an N-terminal helix-turn-helix (HTH) domain, which binds to a specific DNA regulatory element, and a C-terminal co-inducer binding domain.…”

“…To mediate their function, members of this family typically form homotetramers (Henikoff et al, 1988;Maddocks & Oyston, 2008;Oliver et al, 2016;Schell, 1993). LTTRs can function as either activators, repressors or dual regulators of gene expression, and either as local regulators that control the expression of a few genes located adjacent to them or as global regulators (Baugh et al, 2023, Maddocks & Oyston, 2008, Mayo-Perez et al, 2023. The LTTRs family contains numerous transcription factors involved in regulating various physiological processes in bacteria, including biosynthesis, metabolism, quorum sensing, oxidative stress, and virulence gene expression.…”