The LysR‐type transcriptional regulator LelA co‐regulates various effectors in different Legionella species
Naomi Shapira,
Tal Zusman,
Gil Segal
Abstract:The intracellular pathogen Legionella pneumophila translocates more than 300 effector proteins into its host cells. The expression levels of the genes encoding these effectors are orchestrated by an intricate regulatory network. Here, we introduce LelA, the first L. pneumophila LysR‐type transcriptional regulator of effectors. Through bioinformatic and experimental analyses, we identified the LelA target regulatory element and demonstrated that it directly activates the expression of three L. pneumophila effec… Show more
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