Lysine-Derived Maillard Reaction Products Inhibit the Growth of Salmonella enterica Serotype Typhimurium

Wong, Catherine W. Y.; Mu, Kaiwen; Kitts, David D.; Wang, Siyun

doi:10.3390/pathogens12020215

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Gebeyew et al ( 2021 ) reported that dietary lysine supplementation improved intestinal barrier function and down-regulated mRNA expression of intestinal inflammatory factors such as IL-1β, TNF-α, interferon-γ, and toll-like receptor-4. Lysine-derived Maillard reaction products inhibit the growth of Salmonella enterica (Wong et al, 2023 ). The mechanism of their inhibition of Salmonella may be closely related to lysine acetylation, which can inhibit protein activity and DNA binding ability in pathogenic bacteria (Koo et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

Xi,

Yan,

Duan

et al. 2024

Front. Microbiol.

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IntroductionThe short-chain fatty acids (SCFAs) contained in breast milk play a key role in infant growth, affecting metabolism and enhancing intestinal immunity by regulating inflammation.MethodsIn order to examine the associations between the microbiota and SCFA levels in breast milk, and explore the roles of SCFAs in regulating the infant gut microbiota, we enrolled 50 paired mothers and infants and collected both breast milk and infant fecal samples. Breast milk SCFA contents were determined by UPLC-MS, and whole genome shotgun sequencing was applied to determine the microbial composition of breast milk and infant feces. The SCFA levels in breast milk were grouped into tertiles as high, medium, or low, and the differences of intestinal microbiota and KEGG pathways were compared among groups.ResultsThe results demonstrated that breast milk butyric acid (C4) is significantly associated with Clostridium leptum richness in breastmilk. Additionally, the specific Bifidobacterium may have an interactive symbiosis with the main species of C4-producing bacteria in human milk. Women with a low breast milk C4 tertile are associated with a high abundance of Salmonella and Salmonella enterica in their infants' feces. KEGG pathway analysis further showed that the content of C4 in breast milk is significantly correlated with the infants' metabolic pathways of lysine and arginine biosynthesis.DiscussionThis study suggests that interactive symbiosis of the microbiota exists in breast milk. Certain breast milk microbes could be beneficial by producing C4 and further influence the abundance of certain gut microbes in infants, playing an important role in early immune and metabolic development.

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Section: Discussionmentioning

confidence: 99%

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

Xi,

Yan,

Duan

et al. 2024

Front. Microbiol.

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Effects of intrinsic and extrinsic growth factors on virulence gene expression of foodborne pathogens in vitro and in food model systems; a review

Hosseini,

Mahmoudi,

Pakbin

et al. 2024

Food Science & Nutrition

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Since foodborne diseases are one of the major causes of human hospitalization and death, one of the main challenges to food safety is the elimination or reduction of pathogens from food products throughout the food production chain. Pathogens, such as Salmonella species, Escherichia coli, Bacillus cereus, Clostridium species, Staphylococcus aureus, Listeria monocytogenes, Campylobacter species, etc., enter the consumer's body through the consumption of contaminated food and eventually cause disease, disability, and death in humans. In particular, the expression of virulence genes of these pathogens in various food environments containing them has been repeatedly reported, which is a key issue for the survival and pathogenicity of the pathogen. Hence, in this review, the interventions to prevent and control foodborne diseases, such as the application of natural preservatives, redox potential, heat treatments, high‐pressure processing, and gaseous atmosphere, are discussed based on the literature. Moreover, the effects of various environmental conditions on bacterial gene expression are comprehensively reviewed. In conclusion, the effects of intrinsic and extrinsic factors on the growth and pathogenicity of bacteria are very complicated. The information obtained from the current study can be used to develop new control strategies, improve food safety, and ensure human health.

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Lysine-Derived Maillard Reaction Products Inhibit the Growth of Salmonella enterica Serotype Typhimurium

Cited by 2 publications

References 35 publications

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

Effects of intrinsic and extrinsic growth factors on virulence gene expression of foodborne pathogens in vitro and in food model systems; a review

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