Lyophilized Aspirin with Trehalose May Decrease the Incidence of Gastric Injuries in Healthy Dogs

Abstract

ABSTRACT. Trehalose has several novel anti-inflammatory and cell-protective functions. We hypothesized that lyophilized aspirin/trehalose could decrease the severity of aspirin-induced gastropathy. Thirteen dogs were assigned into aspirin, lyophilized aspirin/trehalose, and control groups, and the gastric lesions were assessed on gastroscopy with the modified Lanza scale. Another 6 dogs were used to measure the plasma aspirin concentration by high-performance liquid chromatography after aspirin or lyophilized aspirin/trehalose administration. The results indicated that lyophilized aspirin/trehalose induced less gastric ulceration than aspirin despite maintaining therapeutic concentrations of plasma aspirin in both the groups. Lyophilized aspirin/trehalose might be a solution to decrease aspirin-induced gastropathy.

Dermal Cell Damage Induced by Topical Application of Non-Steroidal Anti-Inflammatory Drugs is Suppressed by Trehalose Co-Lyophilization in <i>Ex Vivo</i> Analysis

“…We speculate that skin penetration of NSAIDs is not inhibited by co-lyophilization with trehalose. These considerations are in agreement with those from our previous study, which showed that co-lyophilization with trehalose does not alter the absorption of aspirin [10]. …”

“…This is consistent with our recent study that co-lyophilized aspirin/trehalose decreased the severity of aspirin-induced gastric ulceration in healthy dogs [10]. We hypothesize that co-lyophilization accelerates the specific interaction between the NSAIDs and trehalose and that this interaction is necessary for a marked reduction of NSAID-induced cell damage.…”

“…We also reported that co-lyophilization of aspirin with trehalose clearly reduced the gastric mucosal damage induced by aspirin [10]. In previous papers, we have hypothesized that trehalose confers protective effects on cellular components, in particular, the cell membrane and thereby suppressed these pathologies [1, 3, 7, 10]. …”

“…We previously reported that trehalose suppressed postsurgical adhesion, several complications after subarachnoid hemorrhage and oral dryness during dental treatment in preclinical or clinical researches [3, 5, 12]. We also reported that co-lyophilization of aspirin with trehalose clearly reduced the gastric mucosal damage induced by aspirin [10]. In previous papers, we have hypothesized that trehalose confers protective effects on cellular components, in particular, the cell membrane and thereby suppressed these pathologies [1, 3, 7, 10].…”