Lymphovascular invasion status at transurethral resection of bladder tumors may predict subsequent poor response of T1 tumors to bacillus Calmette-Guérin

Fukumoto, Keishiro; Kikuchi, Eiji; Mikami, Shuji; Miyajima, Akira; Oya, Mototsugu

doi:10.1186/s12894-016-0122-1

Cited by 12 publications

(12 citation statements)

References 30 publications

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“…Tumor recurrence and stage progression (p = 0.036 and 0.024, hazard ratio = 2.19 and 3.76) were found to be dependent on LVI presence in hematoxylin and eosin (HE) slides. These findings show that LVI has prognostic significance of BCG-treated outcome [10].…”

Section: Resultssupporting

confidence: 55%

Factors Predicting the Outcome of BCG (Bacillus Calmette-Guerin) Therapy

Eidininkas¹,

Simenas²,

Auškalnis³

2022

Health Sciences

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Background: Bacillus Calmette-Guerin is currently considered to be the gold standard in conservative treatment for intermediate and high risk non-muscle invasive bladder cancer (NMIBC). However, up to 40% of the patients, treated with adjuvant BCG therapy, experience failure. As the new methods of treatment after BCG failure appear, there is a need to assess efficacy of this therapy in order to improve appropriate treatment during or before BCG therapy. Aim: To review the latest studies on factors, predicting BCG efficacy, and provide summarized information regarding treatment outcomes in current practice. Methodology: The search was conducted in MEDLINE (Pubmed) and ScienceDirect databases using predetermined keywords: Bacillus Calmette-Guerin (BCG), failure, intravesical therapy, outcome, response, predicting factors, immunological markers, efficacy. 10 articles published since 2017 were included in this literature review. Results: Prognostic factors such as the use of antibiotics prior to the therapy, body mass index (BMI), lymphovascular invasion (LVI), endothelin-1 (ET-1), tumor substaging, CD4/CD8, GATA3/T-bet, CD163/CD68, neutrophil-to-lymphocyte (NLR) ratios are promising factors for estimating the possible response of BCG therapy before undergoing treatment. Blood eosinophil count and percentage, FISH test following 3 months after first BCG instillation and a Cytokine Panel for Response to Intravesical Therapy (CyPRIT) nomogram showed huge potential for predicting BCG outcome during BCG treatment. Conclusion: There are quite many possible clinicopathologic, immunological, immunohistochemical and anamnestical factors that could predict the success of BCG therapy. However, in order to include prognostic factors in treatment guidelines, further studies should be performed to determine which of these factors have the greatest clinical value.

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Section: Resultssupporting

confidence: 55%

Factors Predicting the Outcome of BCG (Bacillus Calmette-Guerin) Therapy

Eidininkas¹,

Simenas²,

Auškalnis³

2022

Health Sciences

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“…Early cystectomy should be considered for carefully selected patients with T1 NMIBC (14). Several studies have identified potential prognostic factors in T1 NMIBC, including sex, age, tumor diameter, CIS, tumor grade, multifocality, lymphovascular invasion, lamina propria invasion, solid tumor pattern, and immunohistochemical detection of p53 in the tumor-cell nuclei (13,(15)(16)(17)(18)(19)(20). However, optimal prediction of recurrence and progression of tumor is still under debate.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of random bladder biopsy in primary T1 bladder cancer

et al. 2018

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Abstract. The clinical significance of random bladder biopsies in primary non-muscle-invasive bladder cancer is unclear. The present study investigated the significance of positive random bladder biopsies in primary T1 NMIBC. The present study retrospectively reviewed the records of 71 patients with primary pT1N0M0 bladder cancer who underwent transurethral resection of the bladder tumor (TURBT) and concomitant random bladder biopsy. A total of 12 patients who received cystectomy immediately following the TURBT were excluded, and the remaining 59 patients were included in the analysis. Random bladder biopsy was defined as a cold-cup biopsy of pre-specified normal-looking areas in the bladder. The association of clinicopathological factors, including random biopsy results, with intravesical recurrence were assessed by univariate and multivariate Cox proportional hazards analyses. Of the 59 patients, 15 (25%) demonstrated carcinoma in situ (CIS) lesions on random bladder biopsy: Five (33%) in biopsy specimens alone and the remaining 10 (67%) in biopsy and TUR specimens. Positive random biopsy was associated with preoperative positive urine cytology (P=0.011) and small size of the main tumor (P=0.008). Multivariate analysis demonstrated positive random biopsy as the sole independent poor prognostic factor for intravesical recurrence (hazard ratio: 4.69, P=0.014). The five patients who had CIS detected in biopsy specimens alone had worse, although non-significantly worse, recurrence-free survival compared with those with CIS detected in biopsy and TUR specimens (P=0.100). In conclusion, positive bladder random biopsy, equivalent to the presence of CIS, was an independent predictor of recurrence in primary T1 bladder cancer. Given that one-third of CIS lesions could not have been detected without biopsy, random bladder biopsy should be considered for patients with T1 tumors.

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“…Definisi invasi limfovaskular yaitu ditemukannya sel-sel tumor di dalam lumen atau menempel pada dinding pembuluh limfatik maupun pembuluh darah. [8][9][10] Menurut Mazzhucelli et al invasi limfovaskular ditemukan sekitar 25-50% pada kasus karsinoma urotelial infiltratif kandung kemih dan hal ini berhubungan dengan derajat keganasan. 11 Penelitian analisis multivariat mengungkapkan bahwa invasi limfovaskular terbukti menjadi faktor prognostik independen pada jaringan biopsi yang diambil melalui tindakan Trans urethral resection of bladder tumour (TURBT) untuk karsinoma urotelial infiltratif kandung kemih stadium T1.…”

Section: Pendahuluanunclassified

The Correlation of VEGF Expression with Grade of Differentiation and Lymphovascular Invasion in Bladder Infiltrating Urothelial Carcinoma

Utami¹,

Agus²,

Yenita³

et al. 2022

MPI

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Background Urothelial carcinoma is the most common malignancy in the bladder with an incidence up to 95% and 70-85% of them are bladder infiltrating urothelial carcinoma. To improve the management of bladder urothelial carcinoma, prognostic factors are required. One such factor is angiogenesis, which affects growth, development and metastasis. Vascular endothelial growth factor (VEGF) is the main pro-angiogenic factor to control angiogenesis. Expression of VEGF is correlated with progression of bladder infiltrating urothelial carcinoma, such as grade and lymphovascular invasion. The aim of this study was to determine the correlation of VEGF expression with grade of differentiation and lymphovascular invasion in bladder infiltrating urothelial carcinoma. Methods This research was a retrospective observational cross sectional study with 48 cases of bladder infiltrating urothelial carcinoma in four Anatomical Pathology Laboratory in West Sumatera 2018 and 2019. Samples were reevaluated of HE slide for grade of differentiation and lymphovascular invasion. VEGF expressions in tumor cell s were analyzed using immunohistochemistry staining. Bivariate statistical analysis used Fisher's Exact test and value p<0.05 was considered significant. Results Bladder infiltrating urothelial carcinoma high grade had more positive VEGF expression (91.7%), while low grade had more negative VEGF expression (58.3%). Lymphovascular invasion positive was mostly found with positive VEGF expression (75%). Statistical analysis showed significant correlation between VEGF expression with grade of differentiation (p=0.001) and lymphovascular invasion (p=0.004). Conclusion The conclusion was VEGF expression had significant correlation with grade of differentiation and lymphovascular invasion of bladder infiltrating urothelial carcinoma.

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Lymphovascular invasion status at transurethral resection of bladder tumors may predict subsequent poor response of T1 tumors to bacillus Calmette-Guérin

Cited by 12 publications

References 30 publications

Factors Predicting the Outcome of BCG (Bacillus Calmette-Guerin) Therapy

Factors Predicting the Outcome of BCG (Bacillus Calmette-Guerin) Therapy

Clinical significance of random bladder biopsy in primary T1 bladder cancer

The Correlation of VEGF Expression with Grade of Differentiation and Lymphovascular Invasion in Bladder Infiltrating Urothelial Carcinoma

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