Lymphotropic Polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects

Delbue, Serena; Tremolada, Sara; Elia, Francesca; Carloni, Camilla; Amico, Serena; Tavazzi, Eleonora; Marchioni, Enrico; Novati, Stefano; Maserati, Renato; Ferrante, Pasquale

doi:10.1016/j.jcv.2009.11.029

Cited by 28 publications

(25 citation statements)

References 20 publications

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“…Interestingly, they found significant differences between the BK and JC viruses with respect to virus-host interaction and epidemiology. Moreover, lymphotropic Polyomavirus and human Bocavirus (HBoV) have also been frequently found in the peripheral blood of immunocompromised and apparently healthy subjects [64,65]. …”

Section: Exploring the Viral Flora In Humansmentioning

confidence: 99%

Describing the Silent Human Virome with an Emphasis on Giant Viruses

et al. 2013

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Viruses are the most abundant obligate intracellular entities in our body. Until recently, they were only considered to be pathogens that caused a broad array of pathologies, ranging from mild disease to deaths in the most severe cases. However, recent advances in unbiased mass sequencing techniques as well as increasing epidemiological evidence have indicated that the human body is home to diverse viral species under non-pathological conditions. Despite these studies, the description of the presumably healthy viral flora, i.e. the normal human virome, is still in its infancy regarding viral composition and dynamics. This review summarizes our current knowledge of the human virome under non-pathological conditions.

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Section: Exploring the Viral Flora In Humansmentioning

confidence: 99%

Describing the Silent Human Virome with an Emphasis on Giant Viruses

et al. 2013

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“…We read with great interest the paper by Delbue and coll., 1 in which the authors detected lymphotropic polyomavirus (LPV) in peripheral blood from HIV-patients and healthy subjects. LPV was first isolated in 1979 from a B-lymphoblastoid cell line of African green monkey 2 and presents features similar to human polyomaviruses BK, JC and Merkel Cell virus and the nonhuman primate SV40, in particular referred to DNA, virion structure and transformation capability, although with significant antigenic differences.…”

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confidence: 99%

Lack of detection of lymphotropic polyomavirus DNA in different clinical specimens

Costa¹,

Bergallo²,

Terlizzi³

et al. 2011

Journal of Clinical Virology

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“…Contradictory findings have been reported previously from different parts of the world regarding the age group specific prevalence of JCPyV. For example, Delbue et al found that age has no significant effect on the molecular prevalence of polyomaviruses [18]. Contrary to that, Sadeghi et al reported that seroprevalence of JCPyV in Australian population increases from 60 to 68% in middle-ages and then decrease to 64% in oldest ages [45].…”

Section: Discussionmentioning

confidence: 98%

Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population

Hussain

Tasneem

Umer

et al. 2017

Virol J

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BackgroundThe BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively. The viruses remain latent primarily in reno-urinary tract, reactivating only in case of a compromised immune system. The seroepidemiology and molecular prevalence of BKPyV and JCPyV have been widely studied both in healthy and immunocompromised patients worldwide. However, data regarding the prevalence of these viruses in the immunocompetent or apparently healthy Pakistani population is lacking. Herein, we present the first ever report on quantitative prevalence of BKPyV and JCPyV in the peripheral blood of a randomly selected cohort of healthy Pakistani population.MethodsA total of 266 whole blood samples were examined. The subjects were divided into three age groups: ≤ 25 years (young), 26–50 years (middle) and ≥ 51 years (elder). Absolute real time PCR assay was designed to quantify the BKPyV and JCPyV viral copy numbers in the range of 106 to 100 copies/mL.ResultsOverall, BKPyV was detected in 27.1% (72/266) individuals while JCPyV in 11.6% (31/266) indicating significant difference (p < 0.005) in the distribution of these two viruses. The prevalence of BKPyV significantly decreased from 51% (49/96) in young age group to 8.2% (7/85) in eldest age group. Whereas, JCPyV positivity rate slightly increased from 8.3% (8/96) in young age group to 11.8% (10/85) in elder age group. The median viral load was calculated as 6.2 log and 3.38 log copies/mL of blood for BKPyV and JCPyV, respectively. Notably, no significant difference in viral load of either of the subtypes was found between different age groups.ConclusionThe current study provides an important baseline data on the prevalence and viral load of circulating BKPyV and JCPyV in Pakistani population. The prevalence and viral load of BKPyV was comparatively higher than JCPyV. The prevalence of BKPyV significantly decreased with increase in age while JCPyV positivity rate slightly increased with increasing age. Viral load of both BKPyV and JCPyV was not correlated with the individual ages.Electronic supplementary materialThe online version of this article (doi:10.1186/s12985-017-0752-2) contains supplementary material, which is available to authorized users.

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Lymphotropic Polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects

Cited by 28 publications

References 20 publications

Describing the Silent Human Virome with an Emphasis on Giant Viruses

Describing the Silent Human Virome with an Emphasis on Giant Viruses

Lack of detection of lymphotropic polyomavirus DNA in different clinical specimens

Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population

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