Lymphotoxicity and myelotoxicity of doxorubicin and SDZ PSC 833 combined chemotherapies for normal mice

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

“…This scenario can be explained by other studies showing that Dox treatment led to the depletion of lymphocytes in peripheral lymphoid organs (Pourtier-Manzanedo et al. 1995 ), lymphocyte stem cells dysfunction and mature lymphocyte destruction (Steele 2002 ). Importantly, the role of antioxidants has been reported in restoring these complications (Merzoug et al.…”

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

“…This scenario can be explained by other studies showing that Dox treatment led to the depletion of lymphocytes in peripheral lymphoid organs (Pourtier-Manzanedo et al. 1995 ), lymphocyte stem cells dysfunction and mature lymphocyte destruction (Steele 2002 ). Importantly, the role of antioxidants has been reported in restoring these complications (Merzoug et al.…”

Liposomal Doxorubicin, but Not Platinum-Taxane, Supports MHC-II Expression and Immune Maturation in the Ovarian Tumor Microenvironment

“…The reason for the relative increase across the immune cell populations s observed in the PLD populations is not completely evident, as doxorubicin is certainly lymphotoxic [ 39 ]. The increase may rather reflect the development of doxorubicin as an encapsulated agent in PLD [ 40 , 41 ].…”

Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats

“…While, doxorubicinassociated granulocytopenia and monocytopenia might be a result of pronounced marrow depression caused by administration of doxorubicin (Falkson et al, 1985;Tsang et al, 2007). On the other hand, doxorubicin-induced lymphopenia could be explained based on the ability of doxorubicin to destroy the population of mature lymphocyte and elimination its precursors (Steele, 2002), depleting lymphocyte number in peripheral blood stream, thymus, spleen and lymph nodes (Pourtier-Manzanedo et al, 1995). The resultant leucopenia and lymphopenia upon treatment with doxorubicin was previously reported by Merzoug et al (2014); Ja´cevi´c et al (2018).…”

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

“…This scenario can be explained by other studies showing that Dox treatment led to the depletion of lymphocytes in peripheral lymphoid organs (Pourtier-Manzanedo et al. 1995 ), lymphocyte stem cells dysfunction and mature lymphocyte destruction (Steele 2002 ). Importantly, the role of antioxidants has been reported in restoring these complications (Merzoug et al.…”

Liposomal Doxorubicin, but Not Platinum-Taxane, Supports MHC-II Expression and Immune Maturation in the Ovarian Tumor Microenvironment

“…The reason for the relative increase across the immune cell populations s observed in the PLD populations is not completely evident, as doxorubicin is certainly lymphotoxic [ 39 ]. The increase may rather reflect the development of doxorubicin as an encapsulated agent in PLD [ 40 , 41 ].…”

Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats

“…While, doxorubicinassociated granulocytopenia and monocytopenia might be a result of pronounced marrow depression caused by administration of doxorubicin (Falkson et al, 1985;Tsang et al, 2007). On the other hand, doxorubicin-induced lymphopenia could be explained based on the ability of doxorubicin to destroy the population of mature lymphocyte and elimination its precursors (Steele, 2002), depleting lymphocyte number in peripheral blood stream, thymus, spleen and lymph nodes (Pourtier-Manzanedo et al, 1995). The resultant leucopenia and lymphopenia upon treatment with doxorubicin was previously reported by Merzoug et al (2014); Ja´cevi´c et al (2018).…”

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

“…This scenario can be explained by other studies showing that Dox treatment led to the depletion of lymphocytes in peripheral lymphoid organs (Pourtier-Manzanedo et al. 1995 ), lymphocyte stem cells dysfunction and mature lymphocyte destruction (Steele 2002 ). Importantly, the role of antioxidants has been reported in restoring these complications (Merzoug et al.…”

Liposomal Doxorubicin, but Not Platinum-Taxane, Supports MHC-II Expression and Immune Maturation in the Ovarian Tumor Microenvironment

“…The reason for the relative increase across the immune cell populations s observed in the PLD populations is not completely evident, as doxorubicin is certainly lymphotoxic [ 39 ]. The increase may rather reflect the development of doxorubicin as an encapsulated agent in PLD [ 40 , 41 ].…”

Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats

“…While, doxorubicinassociated granulocytopenia and monocytopenia might be a result of pronounced marrow depression caused by administration of doxorubicin (Falkson et al, 1985;Tsang et al, 2007). On the other hand, doxorubicin-induced lymphopenia could be explained based on the ability of doxorubicin to destroy the population of mature lymphocyte and elimination its precursors (Steele, 2002), depleting lymphocyte number in peripheral blood stream, thymus, spleen and lymph nodes (Pourtier-Manzanedo et al, 1995). The resultant leucopenia and lymphopenia upon treatment with doxorubicin was previously reported by Merzoug et al (2014); Ja´cevi´c et al (2018).…”