Lymphoscintigraphy Can Select Breast Cancer Patients for Internal Mammary Chain Radiotherapy

Hindié, Elif; Groheux, David; Hennequin, Christophe; Zanotti‐Fregonara, Paolo; Vercellino, Laëtitia; Berenger, Nathalie; Toubert, Marie Elisabeth; Maylin, C.; Vilcoq, J.R.; Espié, Marc

doi:10.1016/j.ijrobp.2011.09.016

Cited by 34 publications

(39 citation statements)

References 24 publications

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“…Nevertheless, it has been reported that patients with positive axilla and internal mammary drainage on lymphoscintigraphy have a significant risk (more than 40%) of internal mammary involvement. 33 No phase III trial has been undertaken to compare the clinical impact of systematic SPECT/CT compared with PI followed by on-demand SPECT/CT. Indeed, such a study would be difficult to conduct.…”

Section: Discussionmentioning

confidence: 99%

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

Vercellino¹,

Ohnona²,

Groheux³

et al. 2014

Clinical Nuclear Medicine

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Section: Discussionmentioning

confidence: 99%

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

Vercellino¹,

Ohnona²,

Groheux³

et al. 2014

Clinical Nuclear Medicine

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“…Other studies have shown that 18 F-FDG PET could be used as a noninvasive method of evaluating the IM nodes [7,8]; however, those studies are limited because there was not pathologic correlation of the positive IM nodes [7,8]. A single study presented as an exhibit at a meeting of the Society of Nuclear Medicine and Molecular Imaging (Cho I, et al, presented at the 2010 annual meeting of the Society of Nuclear Medicine and Molecular Imaging) correlated pathologic biopsy results of nine patients with IM lymph node uptake on PET/CT.…”

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confidence: 95%

¹⁸F-FDG PET/CT–Positive Internal Mammary Lymph Nodes: Pathologic Correlation by Ultrasound-Guided Fine-Needle Aspiration and Assessment of Associated Risk Factors

Wang

Eissa

Rogers³

et al. 2013

American Journal of Roentgenology

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“…[11][12][13] Hindie et al 11 carried out meta-analysis of six prospective studies in which visualization of IM sentinel LN was combined with biopsy. Lymphoscintigraphy data of 3876 BC patients was thoroughly studied.…”

Section: Methodsmentioning

confidence: 99%

Why do we need irradiation of internal mammary lymph nodes in patients with breast cancer: Analysis of lymph flow and radiotherapy studies

Nikolaevich

Vasilevich

2017

Reports of Practical Oncology & Radiotherapy

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a b s t r a c tAim: Using clinical data and results of lymphoscintigraphy to calculate probability of internal mammary lymph node (IMLN) invasion by breast cancer (BC). To evaluate clinical value of lymphoscintigraphy as the guide for irradiation of IMLN.Methods: Using the data of eight published studies that analyzed lymph flow from primary BC (4541pts) after intra-peri-tumoral injection of nanosized 99mTc-colloids we determined probability of lymph-flow from internal-central and external BC to IMLN. In 7 studies (4359pts) axillary staging was accompanied by IMLN biopsy (911pts) that helped us to estimate probability of IMLN metastatic invasion in relation to the status of axillary LN. Finally, we estimated probability of IMLN invasion by BC in five randomized and observation studies that analyzed effect of IMLN irradiation on overall survival (OS). We calculated possible gain in survival if they would be treated according to lymph-flow guided radiotherapy to IMLN.Results: Lymph-flow from internal/central BC to IMLN was mentioned in 35% from external lesions -in 16% cases. In women with negative axillary LN metastases in IMLN were revealed in 7.8%pts, in the case of positive axillary nodes average risk of IMLN invasion increased to 38.1%. Calculated probability of IMLN metastatic invasion in pts included in evaluated trials did not exceed 10%. If lymphoscintigraphy would drive decision about irradiation of IMLN than 72-78% of pts included in these studies would escape radiotherapy to IMLN. In the remaining 21-28%pts with lymph-flow to IMLN their irradiation probably would increase gain in OS from 1.0-3.3% to 4.3-16.8%. Conclusion:Lymphoscintigraphy can be used to optimize the strategy of IMLN irradiation.

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Lymphoscintigraphy Can Select Breast Cancer Patients for Internal Mammary Chain Radiotherapy

Cited by 34 publications

References 24 publications

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

¹⁸F-FDG PET/CT–Positive Internal Mammary Lymph Nodes: Pathologic Correlation by Ultrasound-Guided Fine-Needle Aspiration and Assessment of Associated Risk Factors

Why do we need irradiation of internal mammary lymph nodes in patients with breast cancer: Analysis of lymph flow and radiotherapy studies

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Lymphoscintigraphy Can Select Breast Cancer Patients for Internal Mammary Chain Radiotherapy

Cited by 34 publications

References 24 publications

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

Role of SPECT/CT in Sentinel Lymph Node Detection in Patients With Breast Cancer

18F-FDG PET/CT–Positive Internal Mammary Lymph Nodes: Pathologic Correlation by Ultrasound-Guided Fine-Needle Aspiration and Assessment of Associated Risk Factors

Why do we need irradiation of internal mammary lymph nodes in patients with breast cancer: Analysis of lymph flow and radiotherapy studies

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¹⁸F-FDG PET/CT–Positive Internal Mammary Lymph Nodes: Pathologic Correlation by Ultrasound-Guided Fine-Needle Aspiration and Assessment of Associated Risk Factors