Lymphoreticular Neoplasia and Immunity in Amphibia

Ruben, Laurens N.; Stevens, Jean M.

doi:10.1093/icb/11.2.229

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…She found changes directly related to the presence of the tumour, notably a change in the ratio of y-globulin to albumin, due both to an absolute increase in the concentration of y-globulin and an absolute de crease in the concentration of albumin. R ubkn and Stevens [24] noted that animals with lymphoreticular tumours were unable to mount an allograft re sponse against normal liver or kidney implants. They suggested that tumour bearing Xenopus have reduced cell-mediated immunological responses and compared the situation with immunological unresponsiveness in Hodgkin's disease [I], Thus, the cellular changes in the viscera which accompany the develop ment of the two diseases described in this paper appear to have an immuno logical significance, and the difference between the two diseases may also have an immunological, as well as an aetiological basis.…”

Section: Immunological Aspectsmentioning

confidence: 99%

Mycobacteria and Lymphoreticular Tumours in <i>Xenopus laevis, </i>the South African Clawed Toad

Clothier¹,

Balls²

1973

Oncology

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Lymphoreticular tumours, mycobacterial granulomata and responses to antigens in Xenopus toadlets were compared. Lymphoreticular tumours and granulomata differed in histology, development, distribution of mitotic figures, involvement of small lymphocytes, aetiology and transmissibility. Combination experiments provided no evidence that Mycobacterium marinum plays a role in lymphoreticular tumour initiation and development, though, as in some human neoplasms, secondary mycobacterial infection was a feature of advanced tumours.

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Section: Immunological Aspectsmentioning

confidence: 99%

Mycobacteria and Lymphoreticular Tumours in <i>Xenopus laevis, </i>the South African Clawed Toad

Clothier¹,

Balls²

1973

Oncology

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Suppression of the allograft response by implants of mature lymphoid tissues in larval Xenopus laevis

Ruben

Stevens

Kidder

1972

Journal of Morphology

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One hundred and twenty‐two larvae of Xenopus laevis, the South African clawed toad, at developmental stages 48, 50, 52 and 54, were implanted in the tail with two allografts from adult tissues. In each case, one allograft was from kidney, while the other was either from kidney, thymus, spleen, or liver. In any particular host the two implants were always from the same donor and the implants were all visually matched in size. The experimental period was a maximum of nine days, so as to minimize the large numbers of changes normally accompanying larval progress from stage to stage. We are concerned with the timing of allograft response initiation under the implant conditions of each experimental group at a particular point in development. An allograft response was defined as an infiltration and accumulation of small lymphocytes in the “test” kidney allograft. Larvae of all stages developed allograft responses within one week post‐implantation when the variable implant was from kidney, but implants from spleen and thymus suppressed both the timing of initiation and the subsequent intensity of the response. Spleen was more effective in this regard than thymus and both were more effective in the earlier larval stages. Liver proved to be toxic to the larvae. The relationship between the maturation of the lymphomyeloid tissues and external morphological staging is also discussed.

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Primary Lymphoreticuloses of the Nervous System in Animals

Koestner

1975

Malignant Lymphomas of the Nervous System

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Lymphoreticular Neoplasia and Immunity in Amphibia

Cited by 4 publications

References 11 publications

Mycobacteria and Lymphoreticular Tumours in <i>Xenopus laevis, </i>the South African Clawed Toad

Mycobacteria and Lymphoreticular Tumours in <i>Xenopus laevis, </i>the South African Clawed Toad

Suppression of the allograft response by implants of mature lymphoid tissues in larval Xenopus laevis

Primary Lymphoreticuloses of the Nervous System in Animals

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