Lymphoplasmacyte-rich meningioma: A case report with histological and immunohistochemical studies

Mizushima, Minoru; Tanaka, Yorihisa; Kawakami, Shin; Hori, Tomokatsu; Ohama, Eisaku

doi:10.1007/bf02478870

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…[ 9 ] Immunohistochemical assays indicated that the lymphoplasmacellular proliferation probably represents an immune reaction of the host. [ 10 ] However, the relationship between inflammatory lesions and meningiomas remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Lymphoplasmacyte-rich meningioma with invasion of bone: A case report and review of literature

et al. 2016

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Lymphoplasmacyte-rich (LPR) meningioma is a rare variant of meningioma, which is characterized by conspicuous infiltration of plasma cells and lymphocytes and a variable proportion of meningothelial elements, and is classified as a grade I tumor in World Health Organization (WHO) classification of tumors of central nervous system. The origin and biological behavior of this rare variant of meningioma is still not clear. Till date, very few cases of LPR meningioma have been reported globally. Here, we are presenting a case of right parietal convexity LPR meningioma with invasion of bone in a 32-year-old male patient, who presented to us with complaints of focal seizures and weakness in left upper limb.

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Section: Discussionmentioning

confidence: 99%

Lymphoplasmacyte-rich meningioma with invasion of bone: A case report and review of literature

et al. 2016

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“…The classical appearance of this lesion is a slowly growing, rubbery, well demarcated, rounded nodule with a broad dural attachment, arising over the cerebral convexities, often parasagittal in association with the falx and venous sinus. Other sites include sphenoid ridges, olfactory grooves, parasellar regions, petrous ridges, tentorium and posterior fossa (2,3,8,9,12,13,19) .…”

Section: Discussionmentioning

confidence: 99%

“…There is often a background of predominantly B-cell lymphocytes (CD20 positive) and a minor population of CD3-positive T cells. Idiopathic hypertrophic pachymeningitis is a disease in which there is thickening of the dura, enhancement on appropriate imaging studies, and no microorganisms or other inflammatory disease are recognized (1,2,4,5,11,13,14,(16)(17)(18) .…”

Section: Discussionmentioning

confidence: 99%

Lymphoplasmacyte-rich meningioma: a case report of a rare neoplasm

Cambruzzi¹,

Souza²,

Silveira³

et al. 2012

J. Bras. Patol. Med. Lab.

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Primeira submissão em 25/12/11 Última submissão em 17/02/12 Aceito para publicação em 26/02/12 Publicado em 20/06/12 Lymphoplasmacyte-rich meningioma (LPM) is a rare variant of meningioma, which is characterized by massive inflammatory cell infiltration and rare meningothelial elements. The authors report the clinicopathological features of a LPM located at the right parietal convexity in a patient with generalized tonic-clonic seizures and paresthesia in the left arm. The surgical specimen consisted of a gray nodule measuring 3.5 × 3 × 1.8 cm. At microscopy, a few epithelioid cells associated with numerous lymphocytes/ plasma cells were identified. Positive immunoexpression for epithelial membrane antigen (EMA) and progesterone receptor was found in the epithelioid cells, and positive staining for CD3, CD5 and CD20 in the inflammatory cells. Thus, the diagnosis of LPM was established.

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“…However, there is still some controversy about whether it represents a distinct entity, as its behavior often resembles that of an inflammatory condition 2,3 . The clinicopathological features of patients with LPM vary in terms of tumor location, age, clinical prognosis and the biological behavior of the tumor cells 2–14 . Systemic hematological abnormalities, including hyperglobulinemia and iron refractory anemia have been documented in some patients with LPM 6,7,13 .…”

Section: Introductionmentioning

confidence: 99%

Lymphoplasmacyte‐rich meningioma: A convexity mass with regional enhancement in the adjacent brain parenchyma

Nakayama¹,

Watanabe²,

Suzuki³

et al. 2011

Neuropathology

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Lymphoplasmacyte-rich meningioma (LPM) is a rare, benign variant of meningioma, characterized by massive inflammatory cell infiltration and a variable proportion of meningothelial tumorous elements. Here we report the clinicopathological features of an LPM located at the right frontal convexity in a 37-year-old woman. The patient had suffered an initial generalized tonic-clonic seizure when she was 32 weeks pregnant. The lesion exhibited low intensity on T1-weighted MRI and high intensity on T2-weighted images, with surrounding parenchymal edema. The mass exhibited gadolinium enhancement with dural tail signs. Moreover, multiple foci of linear enhancement spreading through the sulci and into the nearby brain parenchyma were evident. At 1 month after parturition, en bloc removal of the mass, the attached dura mater and adjacent brain tissue was performed. Histologically, the mass located in the subdural space was composed of a mixture of B- and T-lymphocytes and plasma cells. Within the mass, multiple small lobules of meningothelial cells showing immunoreactivity for epithelial membrane antigen and vimentin were observed. The inflammatory cells had also infiltrated the subarachnoid and Virchow-Robin spaces, and the dura mater. The cerebral cortex showed ischemic changes, but no tumor cell invasion. On the basis of these histological features, the lesion appeared to be LPM with an inconspicuous meningothelial component and extensive inflammatory infiltration. This case appears to provide useful information on the pathogenesis of this variant.

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Lymphoplasmacyte-rich meningioma: A case report with histological and immunohistochemical studies

Cited by 8 publications

References 11 publications

Lymphoplasmacyte-rich meningioma with invasion of bone: A case report and review of literature

Lymphoplasmacyte-rich meningioma with invasion of bone: A case report and review of literature

Lymphoplasmacyte-rich meningioma: a case report of a rare neoplasm

Lymphoplasmacyte‐rich meningioma: A convexity mass with regional enhancement in the adjacent brain parenchyma

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