Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa‐associated lymphoid tissue lymphoma

Kodama, T; Ohshima, Kouichi; Nomura, Kenichi; Taniwaki, Masafumi; Nakamura, Naoya; Nakamura, Shigeo; Kohno, Shuzo; Yamamoto, Joji; Karube, Kennosuke; Yamasita, Yosimasa; Shirakusa, Takayuki; Kikuchi, Masahiro

doi:10.1111/j.1365-2559.2005.02225.x

Cited by 91 publications

(64 citation statements)

References 39 publications

(61 reference statements)

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“…In a study by Damaj et al, 15 IGH-BCL2 rearrangement at MBR was identified in 11 of 14 patients (79%) by PCR. Kodama et al 16 detected t(14;18)/IGH-BCL2 in 7 of 10 patients (70%) using FISH. More recently, Mori et al 17 reported that they detected the translocation in 20 of their 24 patients (83%) with duodenal FL by using FISH.…”

Section: Discussionmentioning

confidence: 98%

“…Lymphomatous polyposis, which implies that there are multiple, whitish, small, sessile polyps or nodules, is considered 1 of the most characteristic macroscopic findings of intestinal FL. [3][4][5][6][7][14][15][16] An optimal therapeutic strategy for gastrointestinal FL has not been established. Various treatments, including watchful waiting, surgery, chemotherapy, radiotherapy, immunotherapy (rituximab), or a combination of these, have been applied to patients with FL.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] To date, the presence of t(14;18)/IGH-BCL2 in gastrointestinal FL has been examined only in a few investigations in which the clinical significance of the translocation was not specified. [14][15][16][17] In the current study, we retrospectively analyzed the clinicopathologic and molecular features of 48 patients who had gastrointestinal FL, paying special attention to the prevalence and clinical significance of t(14;18)/IGH-BCL2. …”

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confidence: 99%

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Translocation t(14;18)/IGH‐BCL2 in gastrointestinal follicular lymphoma

Yanai

Nakamura

Takeshita

et al. 2010

Cancer

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BACKGROUND: Chromosomal translocation t(14;18)(q32;q21) involving the immunoglobulin heavy chain gene (IGH) and the BCL2 gene (t[14;18][q32;q21]/IGH-BCL2) is present in 60% to 90% of nodal follicular lymphomas. To the authors' knowledge, the prevalence and clinical significance of this translocation have not been examined previously in gastrointestinal follicular lymphomas. METHODS: Clinicopathologic and molecular features were investigated in 48 patients who had gastrointestinal follicular lymphoma. The site of involvement was the duodenum in 54% of patients, the jejunum in 52%, the ileum in 52%, the stomach in 29%, and the colorectum in 15%. The presence of the t(14;18)/ IGH-BCL2 translocation was detected by interphase fluorescence in situ hybridization. RESULTS: Treatment modalities included surgical resection (n ¼ 16), rituximab plus chemotherapy (n ¼ 13), rituximab alone (n ¼ 6), antibiotics (n ¼ 5), and watchful waiting (n ¼ 8). Complete remission (CR) of lymphoma was achieved in 31 patients (65%). The overall survival and event-free survival rates after 5 years were 93% and 68%, respectively. The t(14;18)/IGH-BCL2 was detected in 39 patients (81%). The involvement of multiple sites (69% vs 0%), manifestation of the lymphomatous polyposis type (72% vs 22%), and histologic grade 1 or 2 tumors (92% vs 56%) were more frequent in the t(14;18)-positive group than in the negative group. In addition, the CR rate was lower in the t(14;18)-positive group than in the negative group (56% vs 100%; P ¼.0179), and a trend was observed toward poorer event-free survival in the positive group (P ¼.089). CONCLUSIONS: The t(14;18)/IGH-BCL2 chromosomal translocation occurred frequently in gastrointestinal follicular lymphomas. The current results indicated that this translocation may be a predictor of an adverse clinical course.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Translocation t(14;18)/IGH‐BCL2 in gastrointestinal follicular lymphoma

Yanai

Nakamura

Takeshita

et al. 2010

Cancer

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“…Analyses were performed with previously described methods. 13 Briefly, the fluorescence in situ hybridization (FISH) patterns were interpreted after counting 200 nuclei. A specimen was classified as abnormal and consistent with IGH/BCL2 fusion, BCL6 break, extra copies of BCL2 gene, or extra copies of BCL6 gene, when the number of nuclei observed with these abnormal patterns was 45%.…”

Section: Cytogenetical Analysis and Fluorescence In Situ Hybridizationmentioning

confidence: 99%

BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation

et al. 2008

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Although approximately 10-20% cases of follicular lymphoma lack BCL2 gene rearrangement, there are few reports having described the alternative genetic aberrations and their association about clinicopathological features. In this study, analysis by Fluorescence in situ hybridization of BCL6 gene aberrations in 100 follicular lymphoma cases without IGH/BCL2 rearrangement resulted in the identification of four subgroups. Group I: BCL6 gene rearrangement (n ¼ 41); Group II: BCL6 gene amplification/3q27 gain (n ¼ 30); Group III: the absence of both (n ¼ 23); and Group IV: the presence of both (n ¼ 6). Group II showed higher grade morphology (Grade 3a/b: 93%), higher bcl2 and MUM1 expression (73 and 57%, respectively), and more frequent combination with BCL2 gene amplification/18q21 gain (90%) than the other groups. BCL6 gene aberration, especially amplification/3q27 gain, indicates the presence of certain morphological and phenotypical findings in follicular lymphoma cases without IGH/BCL2 rearrangement.

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“…However, it is now evident that follicular hyperplasia, follicular lymphoma and MALT lymphoma may have indistinguishable endoscopic appearance with multiple small polyp/ mucosal nodules over long segments of intestine. 49,50 …”

Section: Differential Diagnosis Of Extranodal Small B-cell Lymphomasmentioning

confidence: 99%

Extranodal and splenic small B-cell lymphoma

Wotherspoon

2013

Modern Pathology

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Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa‐associated lymphoid tissue lymphoma

Abstract: Our study emphasizes the importance of differentiating MCL, FL and MALT of LP in evaluating prognosis and hence the most suitable therapeutic regimen.

Cited by 91 publications

References 39 publications

Translocation t(14;18)/IGH‐BCL2 in gastrointestinal follicular lymphoma

Translocation t(14;18)/IGH‐BCL2 in gastrointestinal follicular lymphoma

BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation

Extranodal and splenic small B-cell lymphoma

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