Lymphomatosis Cerebri Presenting as Rapidly Progressive Dementia

Weaver, Jonathan D.; Vinters, Harry V.; Koretz, Brandon; Xiong, Zhenggang; Mischel, Paul S.; Kado, Deborah M.

doi:10.1097/01.nrl.0000254706.85609.95

Cited by 30 publications

(20 citation statements)

References 18 publications

(13 reference statements)

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“…Two infiltration patterns of lymphoma cells have been reported: diffuse scattered infiltration, 3,9,15 and both perivascular proliferation and diffuse scattered infiltration. 6,7,10,11,13,14 Most cases of LC were diagnosed as DLBL. 3,[6][7][8][9][10][11][12][13]15 In this case, the cerebral white matter lesion mimicking diffuse leukoencephalopathy resembled typical LC.…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: An autopsy case report

et al. 2009

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A 59-year-old immunocompetent man was admitted to our hospital because of progressive dementia with concomitant bilateral uveitis. The first brain MRI revealed diffuse hyperintense lesions in the cerebral white matter of both hemispheres on a T2-weighted image and fluid-attenuated inversion recovery image. However, another MRI taken more than 1 month later revealed enhanced cohesive mass lesions in the bilateral thalami, in addition to the white matter lesions. The white matter lesions were slightly hyperintense on a diffusion-weighted image and apparent diffusion coefficient map image, suggesting vasogenic edema. One year after the onset of uveitis, he died of respiratory failure. Pathological diagnosis was diffuse large B-cell lymphoma with perivascular proliferation and diffuse scattered infiltration in the cerebrum and brainstem. Microscopically, cohesive mass lesions in the bilateral thalami were a massive cluster of lymphoma cells. This is a case of primary CNS lymphoma (PCNSL) mimicking 'lymphomatosis cerebri (LC)' at first but later exhibiting typical mass lesions, giving rise to the possibility that cases of LC might unmask features of regular lymphomas in their later course more often than believed thus far.

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Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: An autopsy case report

et al. 2009

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“…Lymphomatosis cerebri (LC), an atypical rare form of PCNSL, presents as a diffuse infiltration without the formation of a mass lesion (2). Its appearance on brain MRI is characterized by diffuse leukoencephalopathy, making LC difficult to distinguish from white matter disorders such as infection, inflammation and vascular and toxic diseases (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

et al. 2015

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A 71-year-old immunocompetent man developed cognitive decline and gait disturbance. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without a mass lesion. An analysis of the cerebrospinal fluid (CSF) showed elevated levels of interleukin (IL)-10. The condition of the patient progressively deteriorated, and intravenous high-dose steroids proved ineffective. Detection of nondestructive, diffusely infiltrating, large B-cell lymphoma in biopsy and autopsy specimens led to a diagnosis of lymphomatosis cerebri (LC). On serial MRI, the basal ganglia and white matter lesions increased in parallel with the levels of IL-10. These findings suggest that the IL-10 level in the CSF may represent a potentially useful biomarker for the early diagnosis and monitoring of the disease progression in LC.

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“…Although comprehensive therapy improves progression-free and overall survival (OS) rates compared with untreated patients, the 5-year survival rate of patients that receive treatment remains 20-25% (29). In addition, 35-60% of patients experience ectopic recurrence within two years of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B-cell lymphoma of the central nervous system: A case report and literature review

Chen

et al. 2016

Oncology Letters

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Abstract. The present study reports the clinical diagnosis and management of a patient with primary diffuse large B-cell lymphoma (Bcl) of the central nervous system (CNS). Making an early diagnosis of primary diffuse large Bcl is challenging due to the variable and complicated clinical manifestations of the disease. The relevant literature was reviewed, and high-dose methotrexate, whole brain radiotherapy and highly active antiretroviral therapy was recommended for the patient. The present study elucidates the role of positron emission tomography-computed tomography scans for the diagnosis and management of primary diffuse large Bcl of the CNS, and demonstrates the importance of resection surgery in the management of the disease. Specifically, the present study proposes that resection surgery may be applied in the early stages of disease for patients with a single occupied lesion and increased intracranial pressure.

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Lymphomatosis Cerebri Presenting as Rapidly Progressive Dementia

Cited by 30 publications

References 18 publications

Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: An autopsy case report

Primary central nervous system lymphoma initially mimicking lymphomatosis cerebri: An autopsy case report

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

Primary diffuse large B-cell lymphoma of the central nervous system: A case report and literature review

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