Lymphoma of the Nose and Paranasal Sinuses

Abstract

\s=b\The records of 37 patients with lymphoma of the nose and paranasal sinuses in an 18-year period were studied. The symptoms were divided into three categories: (1) local symptoms: obstruction, bleeding, and rhinorrhea; (2) symptoms of invasion of adjacent structures: facial pain and ear fullness; and (3) systemic symptoms: fever, weight loss, and nocturnal sweating. The presence of an intranasal mass was the most common physical finding. Conventional tomography and computed tomography were helpful for diagnosis. Abnormalities were usually disclosed on biopsy specimens from the nose or mouth. As a rule, several sites in the nose and sinuses were involved. An early diagnosis of sinonasal lymphoma and other malignant neoplasms generally allows effective treatment; therefore, the otorhinolaryngologist should be alert for such disease and, if the clinical picture warrants, should add tomography to the diagnostic workup. (Arch Otolaryngol 1983;109:310-312) According to figures for 1978, malignant lymphoma occurred in 25,000 persons and was the seventh most common cause of death in the United States during that year. Although the nasopharyngeal region, as a portion of the "Waldeyer's ring" area, is recognized as a potential pri¬ mary site of lymphoma, actual involvement of the nose and paranasal sinuses is rare.

Non‐Hodgkin's Lymphoma of the Sinonasal Tract

“…In the Western World this site accounts for 0.2% to 2.0% of all NHL. 2,3 The majority of these lymphomas are of large B‐cell subtype, 4–13 contrasting with those in the Far East 14–20 and South America, 21 which are predominantly of T‐cell subtype (particularly of the natural killer T‐cell type showing CD56 positivity). Primary NHL lymphoma disease in the West is more common in elderly men and is located in the paranasal sinuses, as distinct from the Far East manifestation of the disease, which presents at a younger age and is located in the nasal cavity.…”

Malignant Lymphoproliferative Disorders Extending into the Orbit from the Paranasal Sinuses

“…In previous studies (Abbondanzo and Wenig, 1995;Cuadra-Garcia et al, 1999;Fellbaum et al, 1989;Wilder et al, 1983), NHL of the paranasal sinuses were found to be predominantly of the intermediate-to high grade B-cell lineage or, less commonly, T-cell lymphomas, which occur more frequently in the nasal cavity and when the orbit is involved, are frequently inflamed and indurated (Wong et al, 2006;Cruz et al, 2004). Similarly in our study, all NHLs were intermediate-to high-grade, in marked contrast to the usual primary orbital low-grade small B-cell lymphomas (Margo and Mulla, 1998;.…”

“…These findings imply a subacute to chronic orbital mass with infiltrative and inflammatory characteristics. In addition, sinus congestion and nasal discharge were common (Abbondanzo and Wenig, 1995;Frierson et al, 1984;Wilder et al, 1983). Imaging demonstrated a well-or ill-defined soft tissue mass occupying one or more sinuses extending into the adjacent orbit with destruction of the orbital wall.…”

Mediofacial malignant granuloma: a case report and review of the literature

“…7,8 The lesions in our patient were identical to those described by Stewart and repeated by Valerio 4 and other authors. 2,[9][10][11] These authors described the course of the disease by the appearance of a nonspecific rhinosinusitis, followed by the development of an ulcerous lesion with purulent discharge. The patient's general condition remains surprisingly good throughout the course of the disease.…”