Lymphoid Tissue of the Normal Fallopian Tube—A Form of Mucosal-Associated Lymphoid Tissue (MALT)?

Morris, Huw; Emms, M.; Visser, Tony; Timme, A. H.

doi:10.1097/00004347-198603000-00002

Cited by 41 publications

(25 citation statements)

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“…The percentage of lymphocyte subsets was characteristic in MALT. The major lymphocyte subsets were IgG-and IgM-positive cells in mouse mediastinal milky spots, T cells, IgA-and IgM-positive cells in rat GALT (OTSUKI et al, 1988), pan T cells in rat BALT (OTSUKI et al, 1989a), and suppressor T cells in human fallopian tube-and uterus-associated lymphoid tissues (MORRIS et al, 1986;OTSUKI et al, 1989b;OTSUKI et al, 1990). It remains to be determined if the variety of major lymphocyte subsets among these lymphoid tissues is caused by different exogenous antigens coming to the surface of the lymphoid tissues, or by organ-specificity or species difference.…”

Section: Discussionmentioning

confidence: 99%

Lymphocyte Subpopulations in Mediastinal Milky Spots of Mice: Light- and Electron-Microscopic Immunohistochemical Observations.

Inoue

Otsuki

1992

Archives of Histology and Cytology

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Summary. The structure and distribution of cellular components in the mediastinal milky spots of C57BL/6 mice were studied by electron microscopy and immunohistochemistry. The mediastinal milky spots were generally covered with plump mesothelial cells with hemidesmosome-like structures in small projections of the cytoplasm, and consisted mainly of clusters of lymphocytes, macrophages and fibroblasts. Macrophages and lymphocytes were often seen passing between mesothelial cells and migrating into the pleural cavity. Neither high endothelial venules (HEY) nor lymphatics were present in the mediastinal milky spots. Thy-1(CD5)-, L3/T4(CD4)-and Lyt-2(CD8)-positive cells were located predominantly at the basal area adjacent to fat cells under the lymphoid tissue. IgG-and Ia-positive cells dominated throughout the lymphoid tissue, whereas IgM-positive cells were observed in the lymphoid tissue other than the basal area. Mediastinal milky spots showed a specific distribution of lymphocyte subsets: the T cell area comprised the basal area, and the B cell area was mainly other areas.The mean percentages of CD4-, CD8-, IgM-, IgG-and IgA-positive cells in the mediastinal milky spots were 16.5%, 20.1%, 28.8%, 37.3% and 2.1%, respectively; the percentage of B cells was higher than that of T cells. IgG-and IgM-positive cells were the main lymphocyte subsets in the mediastinal milky spots. The most characteristic finding was that IgA-positive cells were a very minor cellular component.

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Section: Discussionmentioning

confidence: 99%

Lymphocyte Subpopulations in Mediastinal Milky Spots of Mice: Light- and Electron-Microscopic Immunohistochemical Observations.

Inoue

Otsuki

1992

Archives of Histology and Cytology

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“…Most studies on the immune cell infiltration in endosalpinx have been performed in humans (Morris et al, 1986;Kutteh et al, 1990;Hagiwara et al, 1998;Suenaga et al, 1998) and rodents (Parr & Parr, 1985;Dalton et al, 1994). In cows, changes in the distribution of lymphocytes (DuBois et al, 1980), mast cells (DuBois et al, 1980;Ozen et al, 2002) and eosinophils (Matsuda et al, 1983) during different stages of the oestrous cycle have been reported.…”

Section: The Infiltration Of Leukocytes In the Endosalpinxmentioning

confidence: 99%

The Sow Endosalpinx at Different Stages of the Oestrous Cycle and at Anoestrus: Studies on Morphological Changes and Infiltration by Cells of the Immune System

Jiwakanon¹,

Persson

Kaeoket³

et al. 2005

Reprod Domestic Animals

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The oviduct, together with its secretion, forms the environment in which gamete transport, sperm maturation, fertilization as well as early embryo transport and development occur. Morphological aspects, as well as immune cell distribution, have been described only to a limited extent regarding the pig oviduct. To better understand the reproductive physiology, more information is needed regarding morphology and infiltration of immune cells at different stages of the oestrous cycle.The aim of this study was to investigate the morphological changes and the distribution of leukocytes in the sow endosalpinx throughout the oestrous cycle and at anoestrus. Nineteen crossbred sows (Swedish Landrace × Swedish Yorkshire) at late dioestrus (3), prooestrus (3), oestrus (3), early dioestrus (3), dioestrus (3) and anoestrus (4) were used. Oviductal samples from three different parts (isthmus, ampulla and infundibulum), taken immediately after slaughter, were immersion-fixed, embedded in plastic resin and stained with toluidine blue or stored in a freezer at -70°C until analysed by immunohistochemistry (prooestrus and anoestrus) with an avidin-biotin peroxidase method. Quantitative and qualitative examinations of oviductal epithelial and subepithelial connective tissue layers were performed by light microscopy.During all stages, a lower degree of morphological changes in the epithelium (pseudostratification, mitosis and secretory granules) was found in the isthmus compared with ampulla and infundibulum. In the ampulla and infundibulum, pseudostratification, mitotic activity and secretory granules were high at prooestrus/oestrus. Cytoplasmic protrusions of epithelial cells with some extruded nuclei were prominent in ampulla and infundibulum at all stages except for oestrus and early dioestrus.Lymphocytes as well as CD2 and CD3 positive cells were the predominant immune cells in the epithelial layer. The numbers of lymphocytes and CD3 positive cells did not differ among segments and stages. Numbers of CD2 positive cells did not differ between prooestrus and anoestrus while the numbers were significantly higher in the infundibulum than in ampulla and isthmus. Neutrophils were only occasionally found and mainly in the infundibulum.In the subepithelial connective tissue layer, the two most commonly observed immune cell types were lymphocytes and plasma cells. The numbers of lymphocytes as well as CD2 and CD3 positive cells was lower in isthmus than in the other segments (P ≤ 0.001). Higher numbers of plasma cells (P ≤ 0.001) were found in infundibulum than in ampula and isthmus. The numbers of lymphocytes and plasma cells were not significantly different between stages of the oestrous cycle. However, the number of neutrophils differed and were highest at prooestrus in ampulla and infundibulum. The numbers of CD2, CD3 and CD79 positive cells did not differ between prooestrus and anoestrus whereas for CD14 and SWC3 positive cells, the numbers were higher at prooestrus (P ≤ 0.05) than at anoestrus.In the oviduct, the morphology differ...

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“…Another cell type called the ''basal'' or ''reserve'' cell has been previously observed in the fallopian tube [16]. These cells with a clear cytoplasmic halo were found to be lymphoid based on the expression of leukocyte common antigen and the absence of epithelial markers [16,17].…”

Section: Introductionmentioning

confidence: 97%

Stem‐Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

et al. 2012

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Lymphoid Tissue of the Normal Fallopian Tube—A Form of Mucosal-Associated Lymphoid Tissue (MALT)?

Cited by 41 publications

References 0 publications

Lymphocyte Subpopulations in Mediastinal Milky Spots of Mice: Light- and Electron-Microscopic Immunohistochemical Observations.

Lymphocyte Subpopulations in Mediastinal Milky Spots of Mice: Light- and Electron-Microscopic Immunohistochemical Observations.

The Sow Endosalpinx at Different Stages of the Oestrous Cycle and at Anoestrus: Studies on Morphological Changes and Infiltration by Cells of the Immune System

Stem‐Like Epithelial Cells Are Concentrated in the Distal End of the Fallopian Tube: A Site for Injury and Serous Cancer Initiation

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