Lymphoid Cell Surface Markers in Acute Lymphocytic Leukaemia

Pasino, M; Rosanda‐Vadala, C.; Astaldi, A; Tonini, Gian Paolo; Astaldi, G; Perutelli, P; Comelli, A; Bernardi, Bruno; Giovanelli, A; Mori, Pier Giorgio; Massimo, L

doi:10.1111/j.1600-0609.1978.tb02439.x

Cited by 5 publications

References 11 publications

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Sex differences in prognosis of childhood T‐cell leukemia

Penchansky

Whiteside²,

Wollman³

et al. 1982

Med. Pediatr. Oncol.

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Bone marrows of 41 untreated children and adolescents with acute lymphocytic leukemia were studied by combined immunologic and histochemical methods at the time of diagnosis. Eleven were classified as T-cell lymphoblastic leukemias (27%) on the basis of cytochemical stains and E-rosette assay. The patients in this group has low median age of 8 years, relatively low median WBC of 13.4 x 10(3)/cc, 6/11 were female, and only 2/5 males had a mediastinal mass. The girls had a lower median age than boys (7 vs 9 years), none had mediastinal masses or extramedullary involvement, and their survival was greater than 27 months compared to 14 months for the boys (P less than 0.01). All patients were enrolled and treated on the (then) currently active CCSG protocols for ALL. This study emphasizes the fact that not all patients with T-cell ALL have poor prognosis, that sex could be an important factor affecting survival, and that the difference in survival could not be adequately explained by differences in the initial WBC.

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Sex differences in prognosis of childhood T‐cell leukemia

Penchansky

Whiteside²,

Wollman³

et al. 1982

Med. Pediatr. Oncol.

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Mediastinal mass in acute lymphoblastic leukemia

Chilcote¹,

Coccia²,

Sather³

et al. 1984

Med. Pediatr. Oncol.

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Patients with acute lymphoblastic leukemia who have a mediastinal mass at the time of diagnosis are said to have a poor prognosis. However, many factors which may not be independent contribute to the success of treatment. We compared the disease characteristics and results of therapy in children having large mediastinal masses and lymphoblastic leukemia without mediastinal mass. Patients with a mediastinal mass had less evidence of marrow failure but were burdened with considerably more leukemic cells as measured by peripheral blood white count and extent of lymphadenopathy. Since the presence of mediastinal mass was strongly associated with these and other poor prognostic characteristics, we used multivariate techniques to determine which characteristics were independently associated with an increased risk for relapse. White count, extent of lymphadenopathy, age, and sex were significant predictors of early relapse, but when controlled for these variables the presence of a mass did not predict prognosis.

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The Clinical Relevance of Lymphocyte Surface Markers in Adult Acute Lymphoblastic Leukemia

Bloomfield¹

1982

Adult Leukemias 1

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Lymphoid Cell Surface Markers in Acute Lymphocytic Leukaemia

Cited by 5 publications

References 11 publications

Sex differences in prognosis of childhood T‐cell leukemia

Sex differences in prognosis of childhood T‐cell leukemia

Mediastinal mass in acute lymphoblastic leukemia

The Clinical Relevance of Lymphocyte Surface Markers in Adult Acute Lymphoblastic Leukemia

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