Lymphoid cell apoptosis induced by trophoblastic cells: a model of active foeto-placental tolerance

Coumans, Bernard; Thellin, Olivier; Zorzi, Willy; Mélot, F.; Bougoussa, M.; Melen, Laurence; Zorzi, Danièle; Hennen, Georges; Igout, Ahmed; Heinen, Ernst

doi:10.1016/s0022-1759(99)00021-6

Cited by 31 publications

(12 citation statements)

References 14 publications

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“…The expression of FasL mRNA can be detected at the fetal-maternal interface as early as 6 days post-conception in mice and as early as 12 days post-conception in humans [30,31]. Coumans et al [32] found that human CD3+ T cells undergo apoptosis when cultured with human trophoblast due to the expression of FasL. Vacchio and Hodes [33] studied the role of Fas/FasL in the maternal response to the H-Y antigen using TCR transgenic mice.…”

Section: Fas/faslmentioning

confidence: 99%

T cell recognition and immunity in the fetus and mother

Koch

Platt

2007

Cellular Immunology

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All multicellular organisms protect themselves from invasion by allogeneic organisms and cells by mounting immune responses. While protective, allogeneic immune responses present a threat to successful reproduction in eutherian mammals in which the maternal immune system is exposed to the semi-allogeneic fetus. Thus, successful reproduction in eutherian mammals depends on mechanisms that control the potentially hostile maternal immune system without hindering immune responses to potentially deadly infectious organisms. Three general mechanisms have been proposed to explain successful reproduction in mammals; (i) the formation of an anatomical barrier between mother and fetus; (2) expression of allogeneic antigens at a very low level by the fetus; (iii) and hindrance of the maternal immune system responding to fetal antigens. These mechanisms explain in part how the fetus evades the maternal immune system; however, they do not explain fully the survival of the fetus. We hypothesize that site-specific immune suppression may play an important role in successful eutherian reproduction in conjunction with other mechanisms. Site-specific immune suppression at the fetal-maternal interface would protect the fetus while allowing peripheral maternal immune responses to continue unabated.

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Section: Fas/faslmentioning

confidence: 99%

T cell recognition and immunity in the fetus and mother

Koch

Platt

2007

Cellular Immunology

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“…It might be active in controlling trophoblastic growth and elimination of cells endangering trophoblastic cells (Fig. 5), Coumans et al, 1999;Runic et al, 1998). This without endangering the trophoblasts themselves.…”

Section: Means Of Tolerancementioning

confidence: 99%

Pregnancy and the immune system: between tolerance and rejection

Thellin

Heinen

2003

Toxicology

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Interactions between the conceptus and the mother are bi-directional: the feto-placental tissues need nutrition and a suitable environment in homeostatic condition whereas the mother influenced by the placental factors adapts her metabolism and immune system. Many different mechanisms acting locally or at distance ensure tolerance of the semiallogeneic graft by the maternal natural and adaptive immune defences. In front of this tolerance, mechanisms exist ensuring rejection of the conceptus by the mother (spontaneous abortion) through rupture of one or more tolerance mechanisms, notably in stress situations endangering the mother. Thus outcome of a pregnancy is dependent on efficiently working tolerance mechanisms, and rupture of such mechanisms can lead to rejection. The balance of influence leading either to tolerance or rejection is under control of internal (maternal and fetal) and external (environmental) factors. Rejection, if triggered, mainly occurs through immune-induced inflammation, tissue degradation and coagulation. #

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“…Cultured trophoblastic cells are able to induce apoptosis in blood T cells expressing CD95 [38]. It is notable that trophoblastic cells also express CD95 ( [39]; O Thellin, B Coumans, E Heinen, unpublished data) but apparently do so without full apoptotic consequences for these cells [40].…”

Section: Cd95 and Its Ligandmentioning

confidence: 99%