Tolerance to the foeto-placental ‘graft’: ten ways to support a child for nine months

Thellin, Olivier; Coumans, Bernard; Zorzi, Willy; Igout, Ahmed; Heinen, Ernst

doi:10.1016/s0952-7915(00)00170-9

Cited by 196 publications

(127 citation statements)

References 57 publications

(51 reference statements)

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“…CD85j broadly recognizes several HLA class I alleles and loci, including nonclassical class I molecules such as HLA-G (30 -32). Interestingly, HLA-G is expressed strongly by fetal tissues and plays an essential role in maintaining the fetal graft during pregnancy by blocking locally the maternal immune response (48,49). CD85j might therefore be involved in the abrogation of DC activation in the course of maternal tolerance.…”

Section: Discussionmentioning

confidence: 99%

CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells

Tenca

Merlo

Merck

et al. 2005

The Journal of Immunology

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Immature dendritic cells (DCs) derived from freshly isolated human monocytes were used to evaluate the effect of the inhibiting receptor CD85j (leukocyte Ig-like receptor-1/ILT2) on activation induced by cross-linking of the human osteoclast-associated receptor (hOSCAR). CD85j and hOSCAR were expressed consistently at the same density on monocytes and on monocyte-derived DCs (both immature and mature). Cross-linking of hOSCAR, which activates via the FcR-associated γ-chain, induced Ca2+ flux in DCs. Concomitant cross-linking of anti-CD85j mAb abolished this early activation event. Likewise, CD85j stimulation strongly reduced IL-8 and IL-12 production by hOSCAR-activated DCs. Inhibition of DCs via CD85j also impaired their ability to enhance Ag-specific T cell proliferation induced by hOSCAR. Finally, because hOSCAR prevents apoptosis of DCs in the absence of growth/survival factors, CD85j cross-linking was able to counteract completely this antiapoptotic effect and to reduce Bcl-2 expression enhanced by hOSCAR stimulation. Thus, CD85j is an inhibiting receptor that is functional in human DCs.

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Section: Discussionmentioning

confidence: 99%

CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells

Tenca

Merlo

Merck

et al. 2005

The Journal of Immunology

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“…It can be compared with a semi-allogeneic graft which has to be tolerated over all the gestational period (for review see Thellin et al, 2000).…”

Section: Between Tolerance and Rejectionmentioning

confidence: 99%

“…Indeed, progesterone, an hormone synthesized in large quantities by the placenta, is able to lower immune responses (Siiteri and Stites, 1982). Other hormones, such as the placental growth hormone which replaces progressively the pituitary growth hormone during pregnancy (Hennen et al, 1985), might also help to modulate the immune system (Thellin et al, 2000). Anergy, also called peripheral tolerance, might be induced by fetal antigens or whole cells passing into the maternal blood circulation and the peripheral lymph organs.…”

Section: Means Of Tolerancementioning

confidence: 99%

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Pregnancy and the immune system: between tolerance and rejection

Thellin

Heinen

2003

Toxicology

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Interactions between the conceptus and the mother are bi-directional: the feto-placental tissues need nutrition and a suitable environment in homeostatic condition whereas the mother influenced by the placental factors adapts her metabolism and immune system. Many different mechanisms acting locally or at distance ensure tolerance of the semiallogeneic graft by the maternal natural and adaptive immune defences. In front of this tolerance, mechanisms exist ensuring rejection of the conceptus by the mother (spontaneous abortion) through rupture of one or more tolerance mechanisms, notably in stress situations endangering the mother. Thus outcome of a pregnancy is dependent on efficiently working tolerance mechanisms, and rupture of such mechanisms can lead to rejection. The balance of influence leading either to tolerance or rejection is under control of internal (maternal and fetal) and external (environmental) factors. Rejection, if triggered, mainly occurs through immune-induced inflammation, tissue degradation and coagulation. #

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“…O feto é resultante da união entre dois indivíduos incompatíveis do ponto de vista imunológico, e tem sido comparado a um enxerto semi-alogenêico, pois expressa moléculas do complexo de histocompatibilidade principal (MHC) tanto materno quanto paterno e, por isso, o sistema imune da mãe precisa "driblar" os antígenos fetais durante toda a gestação (THELLIN et al, 2000). terço final da prenhez, as células trofoblásticas nas regiões intercarunculares e nas regiões da arcada da placenta passam a expressa-las, podendo, desta maneira, induzir ao parto.…”

Section: Tolerância Imunológica E a Gestaçãounclassified

Imunofenotipagem de leucócitos da placenta bovina

Chucri

Monteiro

Lima

et al.

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Tolerance to the foeto-placental ‘graft’: ten ways to support a child for nine months

Cited by 196 publications

References 57 publications

CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells

CD85j (Leukocyte Ig-Like Receptor-1/Ig-Like Transcript 2) Inhibits Human Osteoclast-Associated Receptor-Mediated Activation of Human Dendritic Cells

Pregnancy and the immune system: between tolerance and rejection

Imunofenotipagem de leucócitos da placenta bovina

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