Lymphoepithelioma-like Carcinoma of the Skin in the Cheek with a Malignant Metastatic Cervical Lymph Node

Lee, Jong-Ho; Park, Jihoon; Chang, Hak

doi:10.5999/aps.2015.42.5.668

Cited by 5 publications

(2 citation statements)

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“…LELCS has an exceedingly low metastatic potential. There have been only five previously documented cases of lymph node spread [4–7], two of them originating from the head and neck region [6, 7]. We report the case of an 80-year-old male with a tumor primarily located on the lower eyelid, with two regional recurrences and a cervical lymph node spread after surgery, treated with concurrent chemoradiation.…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a recurrent and metastatic case

et al. 2019

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Primary lymphoepithelioma-like carcinoma of the skin (LELCS) is a very rare cutaneous neoplasm. Only about 70 cases have been documented in the literature. There are no prospective data regarding treatment methods. Surgical excision is sufficient therapy in the majority of cases. Radiation therapy is sometimes used in case of recurrence or positive margins after surgery. The metastatic potential of LELCS is extremely low and only five previously documented cases of lymph node spread have been reported. We present the case of an 80-year-old male with a tumor primarily located on the lower eyelid, with two regional recurrences and cervical lymph node spread after surgery, treated with concurrent chemoradiation. According to the available data, this is the first case of lymph node spread from an eyelid location and the first nodal recurrence after surgery.

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Section: Introductionmentioning

confidence: 99%

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a recurrent and metastatic case

et al. 2019

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“…Lymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and has been reported to occur in other sites of the body such as gastrointestinal tract [ 1 ], liver [ 2 ], lung [ 3 ], skin [ 4 ], uterus [ 5 ], gallbladder [ 6 ], pancreas [ 7 ], kidney [ 8 ], and breast [ 9 ]. First reported in 1991 [ 10 ], LELC of the bladder appears to resemble LELC histologically in the nasopharynx but is actually a variant of urothelial carcinoma and has an incidence of about 1% of all bladder carcinomas [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

et al. 2017

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BackgroundLymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body. First reported in 1991, bladder LELC has an incidence of about 1% of all bladder carcinomas. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined.MethodsA PubMed search was performed using two terms, “lymphoepithelioma-like carcinoma” and “bladder.” Review articles, articles in foreign languages, expression studies, and studies not performed in the bladder were excluded. We report a case of LELC of the bladder including treatment and outcome and performed a systematic review of all 36 available English literatures from 1991 to 2016 including the present case to identify factors affecting disease-free survival.ResultsOne hundred forty cases of bladder LELC were analyzed. The mean age of the patients was 70.1 years ranging from 43 to 90 years with 72% males and 28% females. Pure LELC occurs most often at 46% followed by mixed LELC 28% and predominant LELC 26%. EBV testing was negative in all cases tested. Mean follow-up length for all cases was 33.8 months with no evidence of disease in 62.2%, while 11.1% died of disease, 10.4% alive with metastasis, and 8.2% died without disease. 5.0% of cases had recurrence at an average of 31.3 months. Prognosis is significantly favorable for patients presenting with pure or predominant forms of LELC compared to mixed type (p < 0.0001). The treatment significantly associated with the highest disease mortality and lowest disease-free survival was TURBT alone when compared to any multi-modality treatment (p < 0.01).ConclusionWe conclude that the best treatment modality associated with the highest disease-free survival is multi-modal treatment including radical cystectomy.

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Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically

Wick

Cruz²,

Gru

2017

Seminars in Diagnostic Pathology

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Lymphoepithelioma-like Carcinoma of the Skin in the Cheek with a Malignant Metastatic Cervical Lymph Node

Cited by 5 publications

References 5 publications

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a recurrent and metastatic case

Radiotherapy in lymphoepithelioma-like carcinoma of the skin: review of the literature and report of a recurrent and metastatic case

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

Non-lymphoid lesions that may mimic cutaneous hematopoietic neoplasms histologically

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