Lymphoepithelial carcinoma of the parotid gland: Clinicopathological analysis of 146 cases from a single institute

Zhang, Chunye; Gu, Tao; Tian, Zhen; Wang, Lizhen; Han, Jing; Hu, Yuhua; Xia, Ronghui; Li, Jiang

doi:10.1002/hed.27083

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…Iezzoni et al reported that there is a consistent association with EBV in salivary gland LEC whereas there is no association in other anatomic sites [ 8 ]. Parotid LECs have more than 90% association with EBV [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Uncommon Sites of Lymphoepithelial Carcinoma in Head and Neck Region

Venkatasamy¹,

Ramasamy²,

Rahim³

et al. 2023

Cureus

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We present two cases of Lymphoepithelial carcinoma (LEC) which were found in uncommon sites, the first at the right parotid salivary gland and the second at the base of the tongue. Both patients presented with painless neck masses and were diagnosed with histologic analysis. There is an association with Epstein-Barr virus (EBV) infection in the first case, but none was found in the second case. The primary and metastatic LEC are indistinguishable through histological studies. Therefore, examination of nasopharynx and neck imaging is vital to differentiate primary and metastatic LEC in non-nasopharyngeal sites. A collaboration between surgeons and pathologists is essential for accurate diagnosis of LEC. Radiotherapy is the main choice of treatment for LEC, similar to the cases in the nasopharynx.

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Section: Discussionmentioning

confidence: 99%

Uncommon Sites of Lymphoepithelial Carcinoma in Head and Neck Region

Venkatasamy¹,

Ramasamy²,

Rahim³

et al. 2023

Cureus

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“…Unlike nonsebaceous lymphadenoma, lymphoepithelial carcinoma is composed only of lymphoepithelial cells, while tubuloglandular components have not been reported. 2,8,9 Nonsebaceous lymphadenoma shows no or very few mitotic figures, and lymphoepithelial carcinoma often shows marked cellular atypia and brisk mitotic activity. Computed tomography may also be helpful in the differential diagnosis, as cervical lymph node metastasis occurs in approximately half of lymphoepithelial carcinoma cases.…”

Section: Discussionmentioning

confidence: 99%

Nonsebaceous Lymphadenoma of the Salivary Glands: A Potential Overdiagnosis Pitfall

Piao¹,

Gan²,

Li³

2023

Int J Surg Pathol

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Nonsebaceous lymphadenoma is a rare benign salivary tumor. It is easily misdiagnosed as lymphoepithelial carcinoma, leading to overtreatment. Some patients experience sequelae after undergoing cervical lymph node resection and adjuvant treatment, so it is critical to distinguish these entities. We describe the histopathological and immunohistochemical features of this rare entity in 3 cases and discuss the differential diagnosis and histogenesis. Nonsebaceous lymphadenoma can be distinguished from lymphoepithelial carcinoma by the following histological features: There is a lymph node–like form at low magnification, with prominent proliferating epithelial nests but no destructive growth pattern; variable numbers of tubuloglandular components are always seen in proliferating epithelial nests, which transition to cystically dilated salivary ducts; no lesion necrosis exists; and mitotic figures are absent or rare. No patients experienced recurrence during the 8- to 69-month (mean, 29 months) follow-up.

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“…Lymphoepithelial carcinoma is another rare entity and is commonly found in the nasopharynx, parotid gland, larynx, and hypopharynx. 23 , 24 The reported 5-year survival for parotid gland lymphoepithelial carcinoma is 97.0% while that for laryngeal and hypopharynx carcinoma is 68.9%. 23 , 24 The reported prevalence of lymph node metastasis at the time of parotid gland lymphoepithelial carcinoma diagnosis is 31.5%.…”

Section: Discussionmentioning

confidence: 99%

“… 23 , 24 The reported 5-year survival for parotid gland lymphoepithelial carcinoma is 97.0% while that for laryngeal and hypopharynx carcinoma is 68.9%. 23 , 24 The reported prevalence of lymph node metastasis at the time of parotid gland lymphoepithelial carcinoma diagnosis is 31.5%. 23 We also found lymph node metastasis at the time of presentation in children with parotid gland lymphoepithelial carcinoma.…”

Section: Discussionmentioning

confidence: 99%