Lymphocytic Subsets in the Acquired Immunodeficiency Syndrome

Gupta, Sudhir; Licorish, Kenrick; Garthfield, Gary

doi:10.7326/0003-4819-99-4-566_2

Cited by 6 publications

(4 citation statements)

References 2 publications

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“…The changes of the CD4 and CD8 cell in HIV infection are well known [5,6,11]. Our figures confirm that as early as WR1 a significant change occurs in CD4 and CD8 cells.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection

Bogner

Matuschke²,

Heinrich³

et al. 1990

Klin Wochenschr

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“…The changes of the CD4 and CD8 cell in HIV infection are well known [5,6,11]. Our figures confirm that as early as WR1 a significant change occurs in CD4 and CD8 cells.…”

Section: Discussionsupporting

confidence: 78%

“…were the first and most important immunologic changes to be observed when the acquired immunodeficiency syndrome (AIDS) was first seen in the early 1980s [5]. It is beyond doubt that a marked CD4 depletion represents the main feature of cellular immune deficiency [6,10].…”

mentioning

confidence: 99%

Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection

Bogner

Matuschke²,

Heinrich³

et al. 1990

Klin Wochenschr

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“…Initially the inversion of the CD4/CD8 ratio was regarded as the hallmark of the acquired immunodeficiency and the major explanation was seen in the CD44 depletion. How ever, as early as 1983 to 1985 some reports pointed out that not only the relative but also the absolute CD8 + counts were expanded [12,13]. CD8 4 counts of 1500 to 2500/μ1 are commonly found in HIV-infected patients.…”

Section: Cds 4 Lymphocytesmentioning

confidence: 99%

“…The functional disturbance of the immune response caused by HIV infection mainly is known as diminished prolifera tion upon mitogen and antigen stimulation [12]. This phe nomenon is not necessarily linked to T-cell or helper-cell depletion.…”

Section: In Vitro Proliferation Of Lymphocytesmentioning

confidence: 99%

Lymphozytensubpopulationen als Surrogatmarker bei antiretroviraler Therapie

Bogner

Goebel

1991

Infection

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Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals

Gupta

1986

J Clin Immunol

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Peripheral blood mononuclear cells from patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), asymptomatic homosexuals, and healthy heterosexuals were analyzed for the proportions and numbers of Leu 7+ cells and double-labeled Leu 2+7+ cells and for the natural killer functions. A significant increase in the proportions and numbers of Leu 7+ cells was observed in patients with AIDS and ARC and in asymptomatic homosexuals compared to healthy heterosexual men. The proportions of Leu 2+7+ cells were significantly increased in AIDS, ARC, and asymptomatic homosexuals, whereas the numbers were increased in asymptomatic homosexuals and ARC but not in AIDS compared to heterosexual controls. A significant increase in the number of Leu 2+7+ cells was observed in AIDS with Kaposi's sarcoma but not in AIDS with opportunistic infections. The natural killer function was significantly depressed in patients with AIDS and ARC and in asymptomatic homosexuals. These data suggest that the quantitative abnormalities of Leu 2+7+ cells appear early during the evolution of immunologic changes in HTLV III/LAV infection.

show abstract

Lymphocytic Subsets in the Acquired Immunodeficiency Syndrome

Cited by 6 publications

References 2 publications

Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection

Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection

Lymphozytensubpopulationen als Surrogatmarker bei antiretroviraler Therapie

Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals

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