Lymphocytic Choriomeningitis Virus: A New Addition to the TORCH Evaluation

Bechtel, R. T.; Haught, Karen A.; Mets, Marilyn B.

doi:10.1001/archopht.1997.01100150682027

Cited by 21 publications

(3 citation statements)

References 5 publications

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“…8 to 9% of diagnosed cases (1,32). Vertical transmission of LCMV from mother to fetus can result in severe teratogenic consequences, including hydrocephalus, chorioretinitis, or microcephaly (4,5,7,29,31). Currently there are no licensed vaccines available for LCMV.…”

mentioning

confidence: 99%

HLA-A2-Restricted Protection against Lethal Lymphocytic Choriomeningitis

Botten

Whitton

Barrowman

et al. 2007

J Virol

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confidence: 99%

HLA-A2-Restricted Protection against Lethal Lymphocytic Choriomeningitis

Botten

Whitton

Barrowman

et al. 2007

J Virol

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“…A total of 70 cases of congenital LCMV infection were identified. Ten articles reported a single case, 15,[18][19][20][21][22][23][24][25][26] six articles described 2-5 cases, [27][28][29][30][31][32] and three larger series reported 6-20 cases [33][34][35] (Table 1). In 11/70 cases, ultrasound abnormalities were observed during pregnancy: hydrocephaly or ventriculomegaly were the most frequent.…”

Section: Resultsmentioning

confidence: 99%

Congenital lymphocytic choriomeningitis virus: A review

et al. 2022

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Introduction Lymphocytic choriomeningitis virus (LCMV) uses rodents such as mice and hamsters as its principal reservoir. When women acquire LCMV during pregnancy because of contact with rodents, it can lead to congenital LCMV infection, which is associated with high mortality and morbidity. Although the number of cases reported in the literature is increasing, LCMV is rarely mentioned because a history of exposure to rodents is uncommon and mostly unknown. Objectives The main objective of this article was to summarize all morphological, antenatal, and postnatal abnormalities that may suggest a congenital LCMV infection. Methods We reviewed PubMed case reports and case series where an antenatal and/or a postnatal description of at least one case of congenital LCMV infection was documented. Results We found 70 cases of congenital LCMV infection, 68 of which had antenatal or postnatal brain abnormalities, which were mainly chorioretinitis (59/70), hydrocephaly (37/70), microcephaly (22/70), ventriculomegaly (11/70) and periventricular calcifications (11/70). Antenatal and postnatal extracerebral abnormalities were mainly small for gestational age, ascites, cardiomegaly or anemia. Other organ damage was rare, but could include skin abnormalities, hydrops or hepatosplenomegaly. Seventy percent (49/70) of cases had major cerebral abnormalities that could have been detected by antenatal ultrasound examination. Congenital LCMV infection is associated with a significant mortality rate (30%) and survivors often have severe neurologic sequelae. Conclusion LCMV is a rare congenital infection, but awareness of the various prenatal ultrasound morphological abnormalities should be improved, and LCMV should be considered when first‐line etiological explorations are negative, especially when the mother's medical history indicates exposure to rodents.

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“…7 Increased awareness of congenital LCMV infection in recent years has spawned the proposal that it be included in the constellation of congenital TORCH infection. 4 Underdiagnosis and past selection bias have impeded appreciation of the natural history and spectrum of congenital LCMV. 5 Sheinbergas et al 9 estimated that the infant mortality rate in LCMV may be as high as 30%, with the majority of survivors suffering severe neurodevelopmental handicaps.…”

Section: Discussionmentioning

confidence: 99%