Aicardi-like Chorioretinitis and Maldevelopment of the Corpus Callosum in Congenital Lymphocytic Choriomeningitis Virus

Yu, Jennifer T.; Culican, Susan M.; Tychsen, Lawrence

doi:10.1016/j.jaapos.2005.09.009

Cited by 12 publications

(20 citation statements)

References 9 publications

(6 reference statements)

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“…Congenital lymphocytic choriomeningitis virus is not yet a part of the TORCH acronym (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, and Syphilis) that guides clinicians in the care of the mother, fetus, and newborn (1–5,9,10). Congenital lymphocytic choriomeningitis virus infection may be difficult to differentiate from congenital infection secondary to TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, and Syphilis) infections, especially cytomegalovirus, toxoplasmosis, or rubella.…”

Section: Discussionmentioning

confidence: 99%

“…Bonthius et al [1][2][3] used a mouse model to support several proposed mechanisms for congenital lymphocytic choriomeningitis virus infection causing the development of ventriculomegaly and hydrocephalus. Several authors [1][2][3][4][5][6]9,10 have also suggested that congenital lymphocytic choriomeningitis virus infection, as a cause of ventriculomegaly, is common enough to warrant its inclusion in the diagnostic considerations for fetal ventriculomegaly. However, when ventriculomegaly or hydrocephalus has been suspected on the basis of fetal neuroimaging (ultrasonography and/or magnetic resonance), diagnostic practices often neglect testing for lymphocytic choriomeningitis virus.…”

Section: Discussionmentioning

confidence: 99%

“…Common sequelae of congenital lymphocytic choriomeningitis virus infection include structural cerebral anomalies, such as microcephaly, neuronal migration anomalies, periventricular calcifications, pachygyria, porencephalic cysts and periventricular cysts (1,3,5). Hydrocephalus, seizures, and subsequent neurodevelopmental disability are also common (1–6,9,10). Eye findings include chorioretinal lacunae, panretinal pigment epithelium atrophy, bilateral optic nerve dysplasia or atrophy, and reduced caliber of retinal vessels (1–5).…”

Section: Introductionmentioning

confidence: 99%

“…1,3,5 Hydrocephalus, seizures, and subsequent neurodevelopmental disability are also common. [1][2][3][4][5][6]9,10 Eye findings include chorioretinal lacunae, panretinal pigment epithelium atrophy, bilateral optic nerve dysplasia or atrophy, and reduced caliber of retinal vessels. [1][2][3][4][5] Other common findings are nystagmus and strabismus esotropia or exotropia.…”

mentioning

confidence: 99%

“…2 Congenital lymphocytic choriomeningitis virus infection is often misdiagnosed as other infectious, neurologic, ophthalmologic, or chromosomal syndromes, or is lethal in utero. 2,9,10 It has therefore been previously suggested that lymphocytic choriomeningitis virus be added to the list of congenital infections currently included in the TORCH acronym (toxoplasmosis, rubella, cytomegalovirus, herpes, and syphilis). [1][2][3]6,10 In this case study, we present 2 neonates with congenital lymphocytic choriomeningitis virus infection that had unusual antenatal ultrasonographic findings, including ventriculomegaly, intracranial hemorrhage, and hydrops fetalis.…”

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confidence: 99%

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Congenital Lymphocytic Choriomeningitis Virus

et al. 2013

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Lymphocytic Choriomeningitis Virus (LCMV) is a rodent-borne arenavirus that can cause congenital infection affecting the developing central nervous system. When the infection occurs during pregnancy, the virus targets the fetal brain and retina potentially causing ventriculomegaly, hydrocephalus, chorioretinitis, and neurodevelopmental abnormalities. It has been previously suggested that lymphocytic choriomeningitis virus be added to the list of congenital infections currently included in the TORCH acronym (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes, and Syphilis). We present two neonates with antenatally known ventriculomegaly that were diagnosed with congenital lymphocytic choriomeningitis virus infection after birth. In addition to ventriculomegaly, one had non-immune hydrops fetalis and the other had intracranial hemorrhage. In view of the seroprevalence of lymphocytic choriomeningitis Virus (4.7–10%), our findings suggest that screening for congenital lymphocytic choriomeningitis virus infection should be considered in fetuses and newborns with ventriculomegaly as well as other abnormal neuroimaging findings such as intracranial hemorrhage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Congenital Lymphocytic Choriomeningitis Virus

et al. 2013

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Congenital lymphocytic choriomeningitis virus: A review

et al. 2022

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Introduction Lymphocytic choriomeningitis virus (LCMV) uses rodents such as mice and hamsters as its principal reservoir. When women acquire LCMV during pregnancy because of contact with rodents, it can lead to congenital LCMV infection, which is associated with high mortality and morbidity. Although the number of cases reported in the literature is increasing, LCMV is rarely mentioned because a history of exposure to rodents is uncommon and mostly unknown. Objectives The main objective of this article was to summarize all morphological, antenatal, and postnatal abnormalities that may suggest a congenital LCMV infection. Methods We reviewed PubMed case reports and case series where an antenatal and/or a postnatal description of at least one case of congenital LCMV infection was documented. Results We found 70 cases of congenital LCMV infection, 68 of which had antenatal or postnatal brain abnormalities, which were mainly chorioretinitis (59/70), hydrocephaly (37/70), microcephaly (22/70), ventriculomegaly (11/70) and periventricular calcifications (11/70). Antenatal and postnatal extracerebral abnormalities were mainly small for gestational age, ascites, cardiomegaly or anemia. Other organ damage was rare, but could include skin abnormalities, hydrops or hepatosplenomegaly. Seventy percent (49/70) of cases had major cerebral abnormalities that could have been detected by antenatal ultrasound examination. Congenital LCMV infection is associated with a significant mortality rate (30%) and survivors often have severe neurologic sequelae. Conclusion LCMV is a rare congenital infection, but awareness of the various prenatal ultrasound morphological abnormalities should be improved, and LCMV should be considered when first‐line etiological explorations are negative, especially when the mother's medical history indicates exposure to rodents.

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Viral Infections of the Fetus and Neonate

Sánchez¹,

Demmler-Harrison²

2009

Feigin and Cherry's Textbook of Pediatric Infectious Diseases

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Aicardi-like Chorioretinitis and Maldevelopment of the Corpus Callosum in Congenital Lymphocytic Choriomeningitis Virus

Cited by 12 publications

References 9 publications

Congenital Lymphocytic Choriomeningitis Virus

Congenital Lymphocytic Choriomeningitis Virus

Congenital lymphocytic choriomeningitis virus: A review

Viral Infections of the Fetus and Neonate

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