Congenital Lymphocytic Choriomeningitis Virus

Anderson, Jacqueline; Levy, Philip; Leonard, Kaethe; Smyser, Christopher D.; Tychsen, Lawrence; Cole, F. Sessions

doi:10.1177/0883073813486295

Cited by 45 publications

(46 citation statements)

References 15 publications

(112 reference statements)

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“…Microcephaly, congenital hydrocephaly resulting in macrocephaly, and periventricular calcifications are often observed at birth (85). Unlike other TORCH infections and similar to ZIKV infection, signs of systemic infection, such as skin rash, thrombocytopenia, or hepatosplenomegaly, seem to be rarely observed (85,88), although some fetuses present with nonimmune hydrops fetalis (88,97). Late complications include seizures, cerebral palsy, mental retardation, and loss of vision (85).…”

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

“…Similar to ZIKV, LCMV seems to have a strict neurotropism when contracted in utero, and congenital infections result in severe neurological lesions (88,91). Chorioretinitis is the most common finding, and it is observed in almost all infected cases (85); funduscopic examination often shows peripheral scarring, while macular scarring is observed in ZIKV, toxoplasmosis, or CMV infection (85,(92)(93)(94)(95)(96).…”

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

“…Late complications include seizures, cerebral palsy, mental retardation, and loss of vision (85). An association with sensorineural hearing loss has been described; however, it seems to be less frequent than in cases of CMV infection (3/44 cases) (85,88).…”

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

“…Since then, approximately 100 cases have been described, though the prevalence might be higher, as LCMV infection may be misdiagnosed due to lack of knowledge (87,88). LCMV is a rodent-borne zoonotic infection.…”

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

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Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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SUMMARYThe rapid spread of the Zika virus (ZIKV) in the Americas and its potential association with thousands of suspected cases of microcephaly in Brazil and higher rates of Guillain-Barré syndrome meet the conditions for a Public Health Emergency of International Concern, as stated by the World Health Organization in February 2016. Two months later, the Centers for Disease Control and Prevention (CDC) announced that the current available evidence supports the existence of a causal relationship between prenatal Zika virus infection and microcephaly and other serious brain anomalies. Microcephaly can be caused by several factors, and its clinical course and prognosis are difficult to predict. Other pathogens with proven teratogenicity have been identified long before the current ZIKV epidemic. Despite the growing number of cases with maternal signs of infection and/or presence of ZIKV in tissues of affected newborns or fetuses, it is currently difficult to assess the magnitude of increase of microcephaly prevalence in Brazil, as well as the role of other factors in the development of congenital neurological conditions. Meanwhile, health agencies and medical organizations have issued cautious guidelines advising health care practitioners and expectant couples traveling to, returning from, or living in affected areas. Analogous to dengue virus (DENV) epidemics, ZIKV has the potential to become endemic in all countries infested byAedesmosquitoes, while new mutations could impact viral replication in humans, leading to increased virulence and consequently heightened chances of viral transmission to additional naive mosquito vectors. Studies are urgently needed to answer the questions surrounding ZIKV and its role in congenital neurological conditions.

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Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

Section: Lymphocytic Choriomeningitis Virusmentioning

confidence: 99%

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Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

et al. 2016

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“…Virus-induced hearing loss can be the result of a congenital and/or acquired infection and can be uni-or bilateral (6). Lymphocytic choriomeningitis virus (LCMV), the prototypic arenavirus, has been associated with congenital hearing loss (7,8), while viruses such as herpesvirus, HIV, measles, and mumps have been associated with hearing loss after acquired infection.…”

mentioning

confidence: 99%

Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection

Yun

Ronca

Tamura

et al. 2016

J Virol

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Approximately one-third of Lassa virus (LASV)-infected patients develop sensorineural hearing loss (SNHL) in the late stages of acute disease or in early convalescence. With 500,000 annual cases of Lassa fever (LF), LASV is a major cause of hearing loss in regions of West Africa where LF is endemic. To date, no animal models exist that depict the human pathology of LF with associated hearing loss. Here, we aimed to develop an animal model to study LASV-induced hearing loss using human isolates from a 2012 Sierra Leone outbreak. We have recently established a murine model for LF that closely mimics many features of human disease. In this model, LASV isolated from a lethal human case was highly virulent, while the virus isolated from a nonlethal case elicited mostly mild disease with moderate mortality. More importantly, both viruses were able to induce SNHL in surviving animals. However, utilization of the nonlethal, human LASV isolate allowed us to consistently produce large numbers of survivors with hearing loss. Surviving mice developed permanent hearing loss associated with mild damage to the cochlear hair cells and, strikingly, significant degeneration of the spiral ganglion cells of the auditory nerve. Therefore, the pathological changes in the inner ear of the mice with SNHL supported the phenotypic loss of hearing and provided further insights into the mechanistic cause of LF-associated hearing loss. IMPORTANCESensorineural hearing loss is a major complication for LF survivors. The development of a small-animal model of LASV infection that replicates hearing loss and the clinical and pathological features of LF will significantly increase knowledge of pathogenesis and vaccine studies. In addition, such a model will permit detailed characterization of the hearing loss mechanism and allow for the development of appropriate diagnostic approaches and medical care for LF patients with hearing impairment.

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Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

Renauld

Basch

2021

Current Protocols

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Congenital hearing loss is the most common birth defect, estimated to affect 2‐3 in every 1000 births. Currently there is no cure for hearing loss. Treatment options are limited to hearing aids for mild and moderate cases, and cochlear implants for severe and profound hearing loss. Here we provide a literature overview of the environmental and genetic causes of congenital hearing loss, common animal models and methods used for hearing research, as well as recent advances towards developing therapies to treat congenital deafness. © 2021 The Authors.

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Congenital Lymphocytic Choriomeningitis Virus

Cited by 45 publications

References 15 publications

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes

Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection

Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

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