Lymphocytes in Peritumoral Stroma: Evaluation in Epithelial Ovarian Neoplasms

The relation of CD3, CD4, CD8 and PD-1 expression with tumor type and prognosis in epithelial ovarian cancers

“…The presence of TILs in the intratumoral and stromal component of epithelial tumors of the ovary is an important prognostic factor. The diversity of stromal TILs with tumor cell proliferation, invasion, and matrix rearrangement that causes carcinogenesis resulting in different survival creates a tumor-specific microenvironment [3]. Tumor cells modify the tumor microenvironment, both to suppress T-cells and to stimulate tumorigenic inflammation [14].…”

“…PD-1 inhibition ensures proliferation of circulating tumor-specific CD8 + T-cells and reduces the functional depletion of specific T-cells [11]. To improve our current knowledge about the immunological environment of epithelial ovarian tumors, spesific immune cells need to be further investigated in different region tumors [3].…”

“…17 (22.4%) of the cases were Type I, 59 (77.6%) of them were Type II ovarian carcinoma. Their distribution is 59 (77.6%) high grade serous carcinoma, 8 (10.5%) borderline serous carcinoma, 4 (5.3%) clear cell carcinoma, 3…”

“…Ovarian cancers are the second most common malignancy among gynecological malignancies, causing the most frequent death due to nonspecific symptomatology and the absence of effective diagnostic methods that provide early detection [1,2]. According to global statistical data, approximately 295,414 new ovarian cancers and 184,799 deaths were reported worldwide in 2018 [3].…”

“…TIL's; CD4 + and CD8 + T-cells, natural killer (NK) cells, natural killer T lymphocytes (NKT), dendritic cells, CD3 + T-lymphocytes and CD20 + B-lymphocytes are involved in the antitumor immune response. These cells directly participate in the presentation of tumor antigens and/or the attack of tumor cells [3].…”