Lymphocyte transformation in large bowel cancer

Lauder, I.; Bone, G

doi:10.1038/bjc.1973.50

Cited by 27 publications

(4 citation statements)

References 13 publications

(8 reference statements)

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“…in a study of breast cancer, were unable to detect an association between prognosis and lymphocyte count. Our findings support the former view and we have also previously published results showing that lymphocytes from patients with gastrointestinal cancer show a diminished response to phytohaemagglutinin (Lauder and Bone, 1973). The combination of a reduction in number and functional capacity could reasonably be expected to increase the rate of progression of the neoplasm.…”

Section: Disc1ussionsupporting

confidence: 92%

Cellular Immunity, Peripheral Blood Lymphocyte Count and Pathological Staging of Tumours in the Gastrointestinal Tract

Bone¹,

Lauder²

1974

Br J Cancer

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Summary.-The peripheral blood lymphocyte count has been measured in 74 cases of histologically proven carcinoma of the gastrointestinal tract. The count has been correlated with the pathological stage of tumour spread and the patient's delayed hypersensitivity response to 2.4 dinitrochlorobenzene (DNCB). A statistically significant correlation was found between the peripheral blood lymphocyte count and the response to DNCB. There was linear association between the extent of spread of the tumours and the lymphocyte count. Those patients with low peripheral blood lymphocyte counts tended to have more advanced tumours and a poor response to DNCB. The possible causes of this lymphopenia are discussed.

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Section: Disc1ussionsupporting

confidence: 92%

Cellular Immunity, Peripheral Blood Lymphocyte Count and Pathological Staging of Tumours in the Gastrointestinal Tract

Bone¹,

Lauder²

1974

Br J Cancer

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“…The results suggest that not only does immune capacity influence the effect of radiation and the prognosis of the patient, but also that study of the serum-depressive effect could give important information about both the dosage and therapeutic effects of irradiation. DEPRESSED lymphocyte reactivity in cancer patients has been demonstrated for a wide variety of human cancers (Papac, 1970;Ducos et al, 1970;Whittaker and Clarke, 1971 ;Han and Takita, 1972;Lauder and Bone, 1973;Yamagata and Green, 1976). Studies on the immunodepressive effect of the sera of cancer patients have also been frequent (Silk, 1967;Sample et al, 1971;Walker et al, 1973;Whittaker and Clarke, 197 1 ;Suciu-Foca et al, 1973 ;Catalona et al, 1973;Yamagata and Green, 1976).…”

Section: Discussionmentioning

confidence: 99%

Radiation‐induced Immune Changes in Patients With Cancer of the Cervix

Yamagata

Green

1976

BJOG

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Summary Immunological methods were used to estimate the therapeutic effect of irradiation and its influence on the immune capacity of patients with cervical cancer. Patients were examined during and following radiotherapy by means of lymphocyte counts, lymphocytic response to phytohaemagglutinin (PHA), and the depressive effect of their sera on the response of normal lymphocytes to PHA stimulation. Lymphocyte counts and lymphocyte responses during radiotherapy were depressed to 20 to 50 per cent and 10 to 33 per cent respectively of the values found before treatment. Lymphopenia and depressed T‐cell function persisted for years in many patients. The highest values for both lymphocyte counts and reactivities were found in those patients who had unexpectedly good responses to radiotherapy. The immunodepressive effect of patients' sera on normal lymphocyte reactivity decreased and disappeared during therapy and was not present in previously treated patients showing a good prognosis, whereas it showed no change or even increased during therapy in patients with a poor prognosis. The results suggest that not only does immune capacity influence the effect of radiation and the prognosis of the patient, but also that study of the serum‐depressive effect could give important information about both the dosage and therapeutic effects of irradiation.

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“…However, a similar evaluation of patients with nonlymphoid cancer has not produced consistent observations. An impaired lymphocyte response to PHA has been observed in patients with bronchogenic (Han and Takita, 1972;Ducos et al, 1970), squamous cell (Merrin and Han, 1974;Catalona et al, 1973) and colon (Kaplan et al, 1975;Lauder and Bone, 1973) carcinomas, as well as in-patients with sarcomas (Catalona et al, 1973). In contrast, no decline of immunologic function could be detected in patients with carcinoma of the breast until the patients were in the terminal stage of illness (Nemoto et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

Goldrosen

Han

Jung

et al. 1977

Journal of Surgical Oncology

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The in vitro blastogenic response of 76 patients with colon adenocarcinoma and 29 age-matched normal healthy volunteers was compared. An age-related decline in cellular immunocompetence was observed in both the patient and control group. Within each age interval, the patients' blastogenic responses were lower than the controls' and the rate of decline of the blastogenic response in the patient group was greater in magnitude, suggesting that their disease state also contributed to loss of cellular immunocompetence. Thus, both increasing age and presence of tumor are factors that contribute to the decline the immunocompetence in patients with colon adenocarcinoma.

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Lymphocyte transformation in large bowel cancer

Cited by 27 publications

References 13 publications

Cellular Immunity, Peripheral Blood Lymphocyte Count and Pathological Staging of Tumours in the Gastrointestinal Tract

Cellular Immunity, Peripheral Blood Lymphocyte Count and Pathological Staging of Tumours in the Gastrointestinal Tract

Radiation‐induced Immune Changes in Patients With Cancer of the Cervix

Impaired lymphocyte blastogenic response in patients with colon adenocarcinoma: Effects of disease and age

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