Lymphocyte Subpopulations and S-Antigen Reactivity in Retinitis Pigmentosa

Hendricks, Robert L.; Fishman, Gerald A.

doi:10.1001/archopht.1985.01050010065021

Cited by 15 publications

(3 citation statements)

References 6 publications

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“…It is normal when it is part of healthy immune responses which happen frequently and is occasionally abnormal when it is neoplastic or autoimmune in origin. A research has concluded that patients with RP, although not clinically immunologically compromised, have a significantly reduced frequency of T lymphocytes in their peripheral blood due to abnormal expression of HLA-DR antigen on T lymphocytes [23]. The results of comparison of indicators of WBCs in our study also showed that there were no statistically significant differences between the RP group and normal group except BASs, which implies that there was no clinically immunological compromise in patients with RP.…”

Section: Discussionsupporting

confidence: 51%

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Yang

Deng

Tian

et al. 2019

Journal of Ophthalmology

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Purpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP.Design. This is a retrospective observational study.Methods. We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control.Results. The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p<0.01). There were no statistical differences in the other indicators between the RP and normal group.Conclusions. The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis.

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Section: Discussionsupporting

confidence: 51%

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Yang

Deng

Tian

et al. 2019

Journal of Ophthalmology

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“…Retinal detachment may induce cell mediated immune responses to retinal proteins [3]. Different immunological abnormalities and variable in vitro responses to photoreceptor proteins have been found in retinitis pigmentosa [1,[4][5][6][7][8][9]. In addition, other tissue antigens may also elicit autoimmune responses.…”

Section: Introductionsupporting

confidence: 38%

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

et al. 1988

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The immune responsiveness to bovine retinal S-antigen and opsin has been investigated in some retinal disorders by means of in vitro lymphocyte proliferation, leukocyte migration inhibition and enzyme linked immune sorbent assays (ELISA). Sensitisation to S-antigen was observed in serpiginous choroiditis, but not in acute posterior multifocal placoid pigment epitheliopathy (APMPPE) or retinitis pigmentosa. No significant immune responsiveness was detected to opsin in any of the three diseases. Elevated antibody titers to S-antigen were observed in some individual patients and healthy subjects. However, none of the patient groups exhibited an elevated antibody titer as compared to the control group. Although serpiginous choroiditis and APMPPE share some prominent clinical characteristics, the sensitisation in the former disease may perhaps be attributed to more severe and prolonged damage of the photoreceptor cells and blood-retina barrier. A combination of previous and present results suggests that in immunological investigations of retinitis pigmentosa patients it is more effective to use human than bovine S-antigen as test antigen because a species specific epitope seems to be involved.

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“…The above results revealed that the activated T lymphocytes and microglia cells increased in RP patients, which is in line with our immune analysis results, indicating that these two types of immune cells may be involved in the progression of photoreceptor degeneration. Other studies report CD8 T cells decreased, but CD4 T cells unchanged or decreased in peripheral blood in RP patients (Hendricks and Fishman, 1985;Newsome et al, 1988). The different results suggested that a range of immune system dynamics among patients of different mutated genes, various induced drugs and diverse stages of retinal degeneration would be expected.…”

Section: Discussionmentioning

confidence: 93%

Analysis of shared ceRNA networks and related-hub genes in rats with primary and secondary photoreceptor degeneration

Liang,

Fang,

Yao

et al. 2023

Front. Neurosci.

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IntroductionPhotoreceptor degenerative diseases are characterized by the progressive death of photoreceptor cells, resulting in irreversible visual impairment. However, the role of competing endogenous RNA (ceRNA) in photoreceptor degeneration is unclear. We aimed to explore the shared ceRNA regulation network and potential molecular mechanisms between primary and secondary photoreceptor degenerations.MethodsWe established animal models for both types of photoreceptor degenerations and conducted retina RNA sequencing to identify shared differentially expressed long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and messenger RNAs (mRNAs). Using ceRNA regulatory principles, we constructed a shared ceRNA network and performed function enrichment and protein–protein interaction (PPI) analyses to identify hub genes and key pathways. Immune cell infiltration and drug–gene interaction analyses were conducted, and hub gene expression was validated by quantitative real-time polymerase chain reaction (qRT-PCR).ResultsWe identified 37 shared differentially expressed lncRNAs, 34 miRNAs, and 247 mRNAs and constructed a ceRNA network consisting of 3 lncRNAs, 5 miRNAs, and 109 mRNAs. Furthermore, we examined 109 common differentially expressed genes (DEGs) through functional annotation, PPI analysis, and regulatory network analysis. We discovered that these diseases shared the complement and coagulation cascades pathway. Eight hub genes were identified and enriched in the immune system process. Immune infiltration analysis revealed increased T cells and decreased B cells in both photoreceptor degenerations. The expression of hub genes was closely associated with the quantities of immune cell types. Additionally, we identified 7 immune therapeutical drugs that target the hub genes.DiscussionOur findings provide new insights and directions for understanding the common mechanisms underlying the development of photoreceptor degeneration. The hub genes and related ceRNA networks we identified may offer new perspectives for elucidating the mechanisms and hold promise for the development of innovative treatment strategies.

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Lymphocyte Subpopulations and S-Antigen Reactivity in Retinitis Pigmentosa

Cited by 15 publications

References 6 publications

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases

Analysis of shared ceRNA networks and related-hub genes in rats with primary and secondary photoreceptor degeneration

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