Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study

Abstract

Purpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP.Design. This is a retrospective observational study.Methods. We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control.Results. The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p<0.01). There were no statistical differences in the other indicators between the RP and normal group.Conclusions. The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis.

Therapeutic Role of Crinum glaucum Bulb against Haematological and Hepatic Enzyme Alterations in a Rat Model

“…Blood is composed of plasma and several kinds of cells, such as red blood cells (RBC), white blood cells (WBC), hemoglobin (HGB), mean corpuscular volume (MCV), lymphocytes (LYMPH), hematocrit (HCT), platelets (PLT), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC), that exist at constant levels, suggesting the existence of feedback regulatory mechanisms in the body system. They perform many important roles, such as supplying oxygen and nutrients to cells and tissues, transporting hormones and signals, removing wastes, regulating body pH and temperature, and helping in immunological functions and coagulation [1,43]. Therefore, these parameters are crucial factors in the determination of hemodynamics in the body, and changes in their concentrations are associated with abnormal clinical conditions.…”