Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of life

Kampen, Annette H.; Olsen, Ingrid; Tollersrud, Tore; Storset, Anne K.; Lund, Arve

doi:10.1016/j.vetimm.2006.04.001

Cited by 108 publications

(99 citation statements)

References 21 publications

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“…However, there is conflicting evidence about the bovine neonatal innate response. For example, other papers have shown that phagocytosis, respiratory burst and bactericidal activity of calf neutrophils are intact and functional from the first week of life (Kampen et al, 2006); a reduced percentage of phagocytosing cells has been reported in neonatal calves compared with older calves (Menge et al, 1998); and neonatal macrophages have been reported to exhibit enhanced phagocytic activity and oxidative burst activity (Menge et al, 1998). Such conflicting data might result from differences in experimental protocols and read-out parameters.…”

Section: A F G Antonis and Othersmentioning

confidence: 99%

“…Another explanation could be a limited number of circulating B cells in neonates (Chase et al, 2008). However, despite lower numbers of B cells, such calves may have the capacity to respond to an antigen (Kampen et al, 2006). Although further studies are needed, it appears that differences in immune responses, in particular of the natural and pro-inflammatory immune response, are responsible for the differences in clinical appearance of bRSV infection in newborn versus young calves.…”

Section: A F G Antonis and Othersmentioning

confidence: 99%

See 1 more Smart Citation

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Antonis

Jong

Poel

et al. 2010

Journal of General Virology

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Section: A F G Antonis and Othersmentioning

confidence: 99%

Section: A F G Antonis and Othersmentioning

confidence: 99%

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Antonis

Jong

Poel

et al. 2010

Journal of General Virology

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“…Ainda, Ayoub & Yang (1996) verificaram que as contagens absolutas de linfócitos totais permaneceram elevadas e semelhantes até os seis meses de idade em todos os animais avaliados, sendo que o número de linfócitos T declinou a partir do sétimo e oitavo meses de idade, o que também foi observado por Wilson et al (1996), Kulberg et al (2004) e Kampen et al (2006). Porém, ainda no estudo de Ayoub & Yang (1996), o número de linfócitos B aumentou gradativamente, contudo, as causas dessa linfocitose persistente não foram esclarecidas, pois todos os animais apresentavam-se clinicamente sadios.…”

Section: Resultsunclassified

Imunofenotipagem e avaliação quantitativa de linfócitos circulantes de bovinos da raça Curraleiro

et al. 2009

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Pesq. Vet. Bras. 29(4): 339-344, abril 2009 RESUMO.-Este estudo teve por objetivo traçar o perfil imunológico, pela marcação imunocitoquímica e quantificação de linfócitos T e B, de bovinos da raça Curraleiro. Para tal, foram utilizados 116 animais entre machos e fê-meas, de diferentes faixas etárias, provenientes de duas propriedades de criação de gado Curraleiro do Estado de Goiás, sendo alocados em grupos conforme a faixa etária, sexo e origem. As amostras de sangue foram colhidas e processadas para a realização da técnica de imunocitoquímica, sendo utilizados os marcadores linfóides espécie-específicos, anti-CD3 (MM1A-BoCD3) e anti-LB (LCTB16A-clone B-B14), para a quantificação de linfócitos T e B, respectivamente. The aim of this study was to establish an immunological profile by marking and quantification of T and B lymphocytes in Curraleiro breed by immunocytochemistry. A total of 116 cattle was used, males and females of different ages, from two farms situated in the Goiás State, Brazil. The animals were allotted into groups according to age, sex and origin. Blood samples were collected and processed in accordance with immunocytochemistry standard technique using lymphoid markers species-specific, as anti-CD3 (MM1A -BoCD3) and anti-LB (LCTB16A-clone B-B14), for T and B lymphocyte counting, respectively. The data were submitted to descriptive statistics, and to Kruskall Wallis and Mann-Whitney tests. The results showed decreased levels of leukocytes, lymphocytes, T lymphocytes and B lymphocytes along the age advance. Absolute values of leukocytes, lymphocytes and T lymphocytes were higher in males than females. None of the evaluated parameters were affected by differences of the management carried out at the two farms.

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“…In the former study, peripheral CD4 + and CD8 + T cell percentages in Holstein calves were the highest in the fetus, and these percentages decreased after birth and became lower than the adult levels by 120 days of age [21]. The  T cell percentage was the highest at birth and decreased to the adult level by 5 months of age [8]. It is known that a significant decrease in T cells is observed in healthy newborns, and this incidence has been examined due to low reactivity to hrIL-2 of the blood mononuclear cells of preterm neonates as compared with adults [10].…”

mentioning

confidence: 79%

Relationship between Diarrhea and Peripheral Leukocyte Population in Neonatal Japanese Black Calves

Ohtsuka

Mukai²,

Tanami³

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Neonatal Japanese Black (JB) calves show a high incidence of diarrhea. The objective of this study was to analyze the immune cell populations of neonatal JB calves in detail and examine its correlation with the incidence of diarrhea immediately after birth. Understanding the immune cell populations is helpful in clinics in order to determine the condition of the immune system for prevention of diseases. Blood samples were obtained from JB calves on the day of birth. The peripheral leukocyte populations were analyzed separately for calves that had diarrhea within 2 weeks after birth (diarrhea group; n=26) and for calves without diarrhea (control group; n=74). The numbers of the peripheral blood CD3 + TcR1-N12 + and CD8 + T cells were significantly lower in the diarrhea group compared with the control group. These findings suggest that the congenital lower peripheral  and CD8 + T cells results in a high risk of diarrhea in neonatal JB calves.

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Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of life

Cited by 108 publications

References 21 publications

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Imunofenotipagem e avaliação quantitativa de linfócitos circulantes de bovinos da raça Curraleiro

Relationship between Diarrhea and Peripheral Leukocyte Population in Neonatal Japanese Black Calves

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