2001
DOI: 10.1099/0022-1317-50-7-627
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Lymphocyte recognition of human parvovirus B19 non-structural (NS1) protein: associations with occurrence of acute and chronic arthropathy?

Abstract: Immune recognition of recombinant parvovirus B19 non-structural (rNS1) protein was studied by immunoblot and lymphoproliferative assays in blood from the following B19 seropositive groups: B19 infected (n 14), B19 exposed but non-infected (n 16), other illness with rash (n 3), chronic arthropathy of unknown aetiology (n 4) and healthy controls (n 7). Sera from 11 B19 seronegative subjects were also studied. Sera collected at initial diagnosis or at the time of accidental B19 exposure in pregnancy were tested f… Show more

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Cited by 24 publications
(27 citation statements)
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References 22 publications
(38 reference statements)
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“…Moreover, significant T cell responses to NS1 have also been reported in recently infected individuals and patients who developed chronic arthropathy following B19 infection [Mitchell et al, 2001]. It is clear from the present study, however, that immunity to NS1 does not appear to be consistent with clearance of B19 infection, at least in this individual suffering from acute lymphoblastic leukemia.…”
Section: Discussioncontrasting
confidence: 71%
“…Moreover, significant T cell responses to NS1 have also been reported in recently infected individuals and patients who developed chronic arthropathy following B19 infection [Mitchell et al, 2001]. It is clear from the present study, however, that immunity to NS1 does not appear to be consistent with clearance of B19 infection, at least in this individual suffering from acute lymphoblastic leukemia.…”
Section: Discussioncontrasting
confidence: 71%
“…Hence, viral persistence may be a precondition for the formation of NS1-specific antibodies (139,247). Conversely, others have found no evidence of NS1 IgG representing a marker of persistent infection or contributing to pathogenesis (152,196,300,345). Most of the studies find that, irrespective of the underlying disease, NS1-specific IgG appears late in infection (Ͼ6 weeks), and the NS1 antibody test may, therefore, be used to exclude very recent infections in patients with an otherwise unclear serology (139,152,300,345 …”
Section: Detection Of Antibodiesmentioning
confidence: 99%
“…VP2 is the major capsid protein and makes up approximately 95% of the 60 capsid protein units in the native virus (2). B19-specific CD4 ϩ T-cell responses to recombinant B19 capsid proteins have been demonstrated in a number of studies but have not been defined at the peptide level (3,5,22). The role that…”
mentioning
confidence: 99%