Lymphocyte-predominant Hodgkin disease manifested as a subcutaneous arm mass.

Nelson, Michael; Petrík, Juraj; Lack, Ernest E.; Glass-Royal, M; Bogumill, George P.; Stull, Margaret A.

doi:10.2214/ajr.155.3.2117380

Cited by 4 publications

(2 citation statements)

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“…In a large retrospective study from the Mayo Clinic, Travis et al [2] reported primary muscle lymphoma in only 8 of 7,000 cases of malignant lymphoma. Many studies have found that the thigh and upper arm are the commonest sites affected by soft tissue lymphoma [2,[6][7][8][9]. The present study was consistent with this, but also found an equal number of cases occurring in the calf ( Table 1).…”

Section: Discussionsupporting

confidence: 91%

Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases

2008

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The purpose was to describe the MRI morphological features and signal intensity (SI) characteristics of 24 histologically proven cases of musculoskeletal soft tissue lymphoma presenting clinically as a suspected primary soft tissue sarcoma. This was a retrospective review of clinical notes and MRI studies of 24 patients with a histologically confirmed diagnosis of lymphoma. All patients presented to a specialist orthopaedic oncology unit with a suspected primary soft tissue sarcoma. Features assessed included lesion size and morphology, location, extension across anatomical compartments and signal intensity characteristics. The lesions were predominantly poorly defined with peritumoral oedema in ten cases. All tumours were of intermediate T1W SI, while 85% of lesions also showed intermediate T2W SI. Almost all cases that were located just deep to the fascia showed subcutaneous extension, while 50% had involvement of more than one muscle compartment. In 29% of cases, there was extension of tumour along the neurovascular bundle. Histo-pathologically, 23 lesions were non-Hodgkin's B-cell lymphoma. The MRI features of primary musculoskeletal soft tissue lymphoma include a mass with intermediate SI on T1W and T2W images, involvement of more than one anatomical compartment, subcutaneous extension and extension along the neurovascular bundle.

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Section: Discussionsupporting

confidence: 91%

Lymphoma presenting as a musculoskeletal soft tissue mass: MRI findings in 24 cases

2008

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“…To the best of our knowledge, there has been only two reported cases that presented as an extremity subcutaneous mass. 4,5 One of them was suggested to arise from brachial lymph nodes similar to the present patient. 4 We therefore recommend that clinicians should keep in mind that HL lesions can appear as subcutaneous masses although the clinical presentation of this patient may be rare.…”

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confidence: 52%

Hodgkin's lymphoma presenting as subcutaneous masses in the left upper arm

Makino

Hara

Hamashima

et al. 2016

The Journal of Dermatology

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Hodgkin's lymphoma presenting as subcutaneous masses in the left upper armDear Editor, Hodgkin's lymphoma (HL) is a lymphoproliferative disorder characterized by Hodgkin and Reed-Sternberg cells. HL frequently involves the lymph nodes of the head and neck region. 1 Extranodal soft tissue manifestation of HL is rare. 2 We herein report a case of HL presenting as subcutaneous masses in the upper arm.A 47-year-old Japanese man presented with two subcutaneous masses without pain and tenderness in his left upper arm, measuring 4.0 cm 9 3.0 cm and 2.0 cm 9 1.0 cm in size ( Fig. 1a). His left axillary lymph node was slightly swollen. No other lymph node was palpable and no other skin lesion was observed. The patient had initially noticed a single mass at 45 years of age; thereafter, the size of the mass gradually increased. Approximately 6 months before visiting our hospital, a new mass developed on the proximal side of the initial mass. Positron emission tomography revealed three isolated lesions in the left axillary region and upper arm. No other abnormality was detected in the lymph nodes or internal organs. Magnetic resonance imaging (MRI) of the left upper arm revealed ovoid masses with low and high signal intensities on T 1 -and T 2 -weighted images, respectively (Fig. 1b). A similar mass was also detected in the left axillary region. A histological examination of a tissue sample obtained from the mass revealed Figure 1. (a) Subcutaneous masses were observed in the left upper arm. (b) A coronal fat-saturated T 2 -weighted image shows multiple masses within the subcutaneous fat tissue of the left upper arm with a high signal intensity. The arrows indicate the masses. (c) Histological examination revealed mononucleated and binucleated large-sized cells among fre quent small-and medium-sized lymphocytes. (hematoxylin-eosin, original magnification 9200). The tumor cells expressed (d) CD15, (e) CD30 and (f) PAX-5 (all 9200). Arrowhead indicates a PAX-5-positive tumor cell. (g) Epstein-Barr virus (EBV) was detected in the nuclei of the tumor cells using in situ hybridization with EBV small RNA-1 (9200).

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