Lymphocyte Fc receptors: the special case of T cells

Sándor, Mátyás; Lynch, Richard G.

doi:10.1016/0167-5699(93)90168-k

Cited by 59 publications

(45 citation statements)

References 43 publications

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“…6F). These results are in accordance with our previous observation and published report (11,47). (Fig.…”

Section: Icsϩc5b-9 Co-signal Triggers Expression Of Genes Associated supporting

confidence: 83%

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FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

Chauhan

Moore

et al. 2016

Journal of Biological Chemistry

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“…6F). These results are in accordance with our previous observation and published report (11,47). (Fig.…”

Section: Icsϩc5b-9 Co-signal Triggers Expression Of Genes Associated supporting

confidence: 83%

“…6F). Previous studies have also shown colocalization of FcR with TCR on activated T-cells (47). In SLE-CD4 ϩ T-cells, the FcR␥ chain associates with the CD3 -chain of TCR and signals via Syk (53).…”

Section: Discussionmentioning

confidence: 96%

FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

Chauhan

Moore

et al. 2016

Journal of Biological Chemistry

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“…Fc␥RIIIa expression was observed in a small number of peripheral T-cells in healthy individuals in earlier studies (13,14). Another study showed that IgM binding T-cells provided helper function, while IgG binding cells provided suppressor function (15).…”

Section: ؉ Helper T-cells Is An Important Finding Since These Receptomentioning

confidence: 93%

Induced Expression of FcγRIIIa (CD16a) on CD4+ T Cells Triggers Generation of IFN-γhigh Subset

Chauhan

Chen

Moore

et al. 2015

Journal of Biological Chemistry

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“…The observation, per se, of CD16 expression on a small number of T cells in healthy peripheral blood donors is not new (11). Already in 1985, Lanier et al (12) provided the first functional analysis of such cells in humans.…”

mentioning

confidence: 99%

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

Björkström

Gonzalez

Malmberg

et al. 2008

The Journal of Immunology

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CTL are crucial in the defense against viral infections. In the course of investigating peripheral blood and intrahepatic CD8 T cells in patients with chronic hepatitis C virus (HCV) infection, we observed a significant population of CD8 T cells expressing the FcγRIIIA (CD16) receptor. This observation led us to characterize these cells with respect to their phenotype and function in a cohort of patients with chronic HCV infection as well as in healthy blood donors. On average, 10% of peripheral blood CD8 T cells from HCV-infected patients expressed CD16 compared with only a few percent in healthy donors. CD16+ CD8 T cells displayed a late-stage effector phenotype with high levels of perforin. These cells exhibited a restricted TCR profile suggesting underlying clonal expansion. Stimulation of CD16 on CD8 T cells evoked a vigorous response similar to that of CD16 stimulation in NK cells. Our data suggest that CD8 T cells, during chronic HCV infection in humans, continue to differentiate beyond defined stages of terminal effector cells, acquiring CD16 and NK cell-like functional properties.

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Lymphocyte Fc receptors: the special case of T cells

Cited by 59 publications

References 43 publications

FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

Induced Expression of FcγRIIIa (CD16a) on CD4+ T Cells Triggers Generation of IFN-γhigh Subset

Elevated Numbers of FcγRIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection

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