Lymphocyte DNA damage in Turkish asphalt workers detected by the comet assay

Bacaksız, Ayşegül; Kayaaltı, Zeliha; Tutkun, Engın; Söylemezoğlu, Tülın

doi:10.1016/j.toxlet.2012.03.702

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings were consistent with previous studies using workers who exposed to arsenic (23,24).This study is also compatible with several studies that arsenic causes genotoxic effects, chromosomal abnormality, sister chromatid exchange, DNA strand breakage, oxidative DNA damage (7,23,27). Studies carried on individuals who have been exposed to various chemicals and toxicants at different occupational settings have shown that DNA damage level increases along with occupational exposure (16,(32)(33)(34)(35)(36). In contrary to these studies, we could not find a statistically significant difference between exposure time and DNA damage.…”

Section: Discussionsupporting

confidence: 93%

Evaluation of Relationship Between Lymphocyte DNA Damages and Blood Arsenic Levels in Silver Mining Workers using Alkaline Comet Assay

Kayaaltı¹,

Kaya-Akyüzlü²,

Tutkun³

et al. 2017

Marmara Pharmaceutical Journal

Self Cite

View full text Add to dashboard Cite

The purpose of this study is to investigate the association between DNA damage and blood arsenic levels in individuals occupationally exposed to arsenic (As). A hundred-twenty exposed individuals from silver mining plate workers were monitored in the way of DNA damage in blood lymphocytes using comet assay (single cell gel electrophoresis, SSGE). The DNA damage levels were measured by BAB Bs Comet Assay system and As levels were analyzed by the atomic absorption spectrometer (AAS) system. The mean blood arsenic level was 17.03±10.85 µg/L. A statistically significant positive correlations were found between the arsenic levels and comet parameters (tail intensity, comet length and tail length) (r=0.360, r=0.334, r=0.259, respectively, p<0.01). Our results showed that exposure to arsenic may cause DNA damage in peripheral lymphocytes of Turkish silver mining plate workers.

show abstract

Section: Discussionsupporting

confidence: 93%

Evaluation of Relationship Between Lymphocyte DNA Damages and Blood Arsenic Levels in Silver Mining Workers using Alkaline Comet Assay

Kayaaltı¹,

Kaya-Akyüzlü²,

Tutkun³

et al. 2017

Marmara Pharmaceutical Journal

Self Cite

View full text Add to dashboard Cite

show abstract

“…Bu çalışma, 30'u asfalt dumanına maruz kalan işçiler ve 30'u kontrol olmak üzere 60 kişiden oluşmaktadır. İşçilerin PAH maruziyetini belirlemek için kan hüpirik asit miktarları ölçülmüş olup, Comet analiz sonuçlarına göre asfalt dumanına maruz kalan işçilerde DNA hasarının daha fazla olduğu saptanmıştır (30,31). Salamura ürünler ve balık konservelerinde koruyucu madde olarak N-nitrözaminli bileşikler, etlerin kırmızı renginin koruması amacıyla da sodyum nitrat kullanılmaktadır.…”

Section: B) Dna'ya Dolaylı Yollarla Etki Edenlerunclassified

Ksenobi̇yoti̇kleri̇n Dna Üzeri̇ndeki̇ Toksi̇k Etki̇leri̇ Ve Toksi̇kogeneti̇k

Özdemir¹,

Kayaaltı²,

Kaya-Akyüzlü³

2015

Marmara Pharm J

View full text Add to dashboard Cite

Lymphocyte DNA damage in Turkish asphalt workers detected by the comet assay

Cited by 2 publications

References 0 publications

Evaluation of Relationship Between Lymphocyte DNA Damages and Blood Arsenic Levels in Silver Mining Workers using Alkaline Comet Assay

Evaluation of Relationship Between Lymphocyte DNA Damages and Blood Arsenic Levels in Silver Mining Workers using Alkaline Comet Assay

Ksenobi̇yoti̇kleri̇n Dna Üzeri̇ndeki̇ Toksi̇k Etki̇leri̇ Ve Toksi̇kogeneti̇k

Contact Info

Product

Resources

About