Lymphocyte cytosolic protein 2 is a novel prognostic marker in lung adenocarcinoma

Abstract

Objective Lymphocyte cytosolic protein 2 (LCP2) is often ectopically expressed in various human tumors. However, the clinical significance and role of LCP2 in lung adenocarcinoma (LUAD) remain unclear. This study explored the prognostic significance of LCP2 in LUAD patients. Methods LCP2 expression in LUAD tissues was analyzed using data from The Cancer Genome Atlas and Genotype-Tissue Expression databases. Western blotting was employed to detect LCP2 expression in LUAD. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to explore signaling pathways mediated by LCP2 co-regulatory genes. Immunohistochemistry was used to examine levels of LCP2 and programmed death ligand 1 (PD-L1) in 68 LUAD patients. Associations between LCP2 expression and clinicopathological features, prognoses, and PD-L1 levels among the LUAD in-patients were analyzed. Results Among the 68 LUAD in-patients, LCP2 expression was correlated with clinical stage and lymph node metastasis. LUAD patients with high LCP2 expression were associated with increased overall survival. LCP2 expression may be associated with an enrichment of several immune functions. Moreover, our immunohistochemistry results demonstrated that LCP2 expression was positively correlated with PD-L1 expression in LUAD tissues. Conclusions In the study, LCP2 was found to be a favorable prognostic biomarker in LUAD patients.

Identification of hub genes and transcription factors in patients with rheumatoid arthritis complicated with atherosclerosis

“…The deficiency of ITGB2 cause leukocyte adhesion deficiency 51 PTPRC protein tyrosine phosphatase receptor type C The protein encoded by this gene is a member of the protein tyrosine phosphatase family. The family is known to be signaling molecules that regulates a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation 52 CTSS cathepsin S The preproprotein encoded by this gene is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules 53 LCP2 lymphocyte cytosolic protein 2 This gene encodes an adapter protein,which is thought to play a role in TCR-mediated intracellular signal transduction 54 CD53 CD53 molecule The encoded protein contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation 55

Figure 4 GO and KEGG enrichment analysis of the hub genes.

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ABI3BP is a prognosis biomarker related with clinicopathological features and immunity infiltration of lung tumor

“…Another core gene, Vav1, accelerates Ras-driven lung cancer and regulates its tumor microenvironment ( Shalom et al, 2022 ) and its mutations can cause different human oncogenic phenotypes. LCP2 is also a good prognostic biomarker for lung cancer patients ( Huo et al, 2021 ). Most of these genes, which function similarly to ABI3BP and both play an inhibitory role in tumors, affect tumorigenesis and progression through different types of mutations.…”

Using bioinformatics and systems biology methods to identify the mechanism of interaction between COVID-19 and nonalcoholic fatty liver disease

“…Changes in the quantity of LCP2 can affect immune regulatory responses. [46,47] Colony-stimulating factor 2 receptor beta (CSF2RB) is a shared subunit of interleukin 3 (IL3), colony-stimulating factor 2 (CSF2) and IL5 receptors involved in signal transduction. [48] CSF2RB polymorphism reduces erythropoietin-mediated NO production, abrogating the protective effect of erythropoietin on SARS-Cov-2.…”