ABI3BP is a prognosis biomarker related with clinicopathological features and immunity infiltration of lung tumor

Abstract

Background: The primary factor of cancer mortality is lung tumor. ABI3BP gene encodes an extracellular matrix bind protein associated to multiplication and derivation. However, the prognosis score of ABI3BP for lung tumor and its relation with immunity cellular infiltration for lung tumor have not been reported.Methods: Public repository systems (Timer, GEPIA, TCGA, HPA) were utilized to explore expression of ABI3BP for lung tumor, and explored the relation of ABI3BP and clinicopathological parameters. TCGA information set was utilized for cox analysis for data with one or more variables of ABI3BP for lung tumor. STRING was utilized to explore ABI3BP regulatory networks. GO/KEGG enrichment analysis as well as enrichment analysis of gene sets were carried out for ABI3BP co-expression via R package. And finally we explored the relation of expression of ABI3BP and lung tumor immunity invasion, exploring the influence of ABI3BP level of expression on immunotreatment and whether immunity invasion would affect the prognosis of patients with lung tumor.Results: ABI3BP is downregulated in LUAD and LUSC, and associated to lung tumor phase and prognosis. Univariate and multivariate cox regression showed that ABI3BP was an independent prognostic factor in patients with lung tumors. The extracellular matrix protein-coding gene and the ABI3BP-related gene were intersected to obtain 10 hub genes. On the basis of GO/KEGG enrichment analysis, hub genes are closely associated to immunity-associated pathways including T cell receptor signaling pathway, immune response−activating cell surface receptor signaling pathway. Finally, the expression of ABI3BP is closely related to immune cell infiltration and immune cell marker set, and the expression of ABI3BP can help predict the therapeutic effect of immune checkpoint inhibitors and improve the prognosis of patients.Conclusion: ABI3BP could be a new target for lung tumor that could be utilized as a diagnostic and therapeutic tool.

The entanglement of extracellular matrix molecules and immune checkpoint inhibitors in cancer: a systematic review of the literature

“…Even if the molecular mechanisms affecting the immune response are still unknown, these data suggest that increased ABI3BP expression may impact on tumor progression also by modulating the tumor immune microenvironment. In accordance with this hypothesis, the expression of ABI3BP in lung cancer correlates with patient’s prognosis, with low expressing patients having a poorer outcome ( 28 ).…”

“…ABI3BP expression has been associated with many physiological and pathological processes ( 99 ), and it is well known for its role in multiple cancer types, acting as a tumor suppressor by inhibiting cancer cell proliferation and migration and promoting cellular senescence ( 100 – 104 ). The role of ABI3BP in lung cancer has been investigated only recently and it has been indicated that this molecule is downregulated in the lesions compared to normal lung tissue and it gradually decreases as lung cancer progresses ( 28 ). Interestingly, in the same work, it has been demonstrated for the first time the association between ABI3BP expression and immune cell infiltration.…”

Study on the correlation between suicidal ideation and ABI3BP gene、DPYSL2 gene methylation in pediatric bipolar disorder with depressive episode

“…ABI3BP has been reported to be associated with many immune cell marker sets in many types of cancer. Yan et al discovered that this gene set is related to biological processes such as apoptosis, cell cycle, and DNA damage and that immune infiltration of tumour cells is associated with ABI3BP expression [ 61 ]. They also found that the increased expression of ABI3BP in tumours may interfere with the tumour immune microenvironment by affecting immune cell infiltration.…”

“…They also found that the increased expression of ABI3BP in tumours may interfere with the tumour immune microenvironment by affecting immune cell infiltration. In addition, ABI3BP is involved in regulating several immune signalling molecules in lung tumours, including immunostimulants, immunosuppressants, MHC, chemokines, and receptors [ 62 ]. Wu et al [ 63 ] found a correlation between DPYSL2 expression and immune cell infiltration in lung adenocarcinomas, including macrophages, dendritic cells, CD4 + T cells, and neutrophils.…”

ABI3BP promotes renal aging through Klotho-mediated ferroptosis

“…Studies have shown that extracellular matrix proteins may be important signs of aging [ 10 ]. ABI3BP, a recently discovered extracellular matrix protein, has been linked to tumor development in numerous studies [ 11 , 12 ]. Knocking down ABI3BP expression has been shown to inhibit tumor growth by affecting tumor cell proliferation, viability, migration, and invasion [ 13 ].…”