Lymphocyte alterations in zinc-deficient calves with lethal trait A46

Perryman, Lance E.; Leach, Dana R.; Davis, William C.; Mickelsen, W. Duane; Heller, S. R.; Ochs, Hans D.; Ellis, John; Brummerstedt, E

doi:10.1016/0165-2427(89)90034-2

Cited by 23 publications

(14 citation statements)

References 17 publications

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“…The zinc deficiency symptoms are also consistent with those observed in zinc-responsive dermatosis in dogs [4,5], acrodermatitis enteropathica in humans [6][7][8], and lethal trait A46 in Black Pied Danish cattle [9,10]. These clinical symptoms include dermatitis, alopecia, anorexia, growth retardation, gastrointestinal dysfunction, defective T-lymphocyte function, and atrophy of the thymus and lymphoid tissues [1].…”

Section: Introductionsupporting

confidence: 54%

Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis

Grider

Mouat

Mauldin

et al. 2007

Molecular Genetics and Metabolism

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Lethal acrodermatitis (LAD) is a genetic disease affecting bull terrier dogs. The phenotype is similar to that for acrodermatitis enteropathica in humans, but is currently without treatment. The purpose of the research presented here is to determine the biochemical defects associated with LAD using proteomic methodologies. Two affected (male and female) and one unaffected (male) bull terrier pups were euthanized at 14 weeks of age, their livers dissected and prepared for twodimensional gel electrophoresis (2DE) and densitometry. Approximately 200 protein spots were observed. The density of the spots within each gel was normalized to the total spot volume of the gel; only those soluble liver protein spots that were consistently different in both of the livers of the affected pups compared to the unaffected pup were excised manually and submitted for MALDI mass spectrometry. Thirteen proteins were identified as differentially expressed in the affected, compared to the unaffected, pups. The proteins were involved in numerous cellular physiological functions, including chaperones, calcium binding, and energy metabolism, as well as being associated with the inflammatory response. Of note were haptoglobin, glutamine synthetase, prohibitin and keratin 10 which exhibited at least a 4-fold level of differential expression. These data represent the first proteomic analysis of this mutation. The differentially expressed proteins that were identified may be key in understanding the etiology of LAD, and may lead to diagnostic tools for its identification within the bull terrier population.

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Section: Introductionsupporting

confidence: 54%

Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis

Grider

Mouat

Mauldin

et al. 2007

Molecular Genetics and Metabolism

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“…An autosomal recessive trait, lethal Trait A46, occurs in Holstein and Shorthorn cattle breeds and results in a decreased ability to absorb Zn. Calves with this inherited trait have an acceptable number of functional lymphocytes at birth, but as the calves become Zn-deficient, lymphocyte activity is altered [ 117 ].…”

Section: Zincmentioning

confidence: 99%

Copper and Zinc Nutritional Issues for Agricultural Animal Production

Hill

Shannon

2019

Biol Trace Elem Res

100

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Livestock have presented unique requirements and toxicity issues depending on the species for the various concentrations of Cu and Zn and their interactions with other nutrients especially Fe, Se, Mo, and S. Soil concentrations of these elements and their availability to crops influence the health of the crop and the amount found in vegetative tissues and seeds. Hence, many livestock issues are a result of the soils in the area where production is occurring (Loneragan et al. 1981 ). While water can provide minerals to animals, the amount consumed and availability are highly variable. Many discoveries about Cu were a result of low Cu concentrations and its availability due to interactions with other nutrients in the soils. Anemia, bone disorders, cardiovascular abnormalities, defective wool and hair, and infertility are signs/symptoms of Cu deficiency. Toxicity due to excess Cu is more likely to occur in sheep than other farm species. Swine are tolerant of high concentrations of dietary Cu, and it is often used as a growth stimulant in production. There are many species and physiological stages where the animal’s Cu requirement is not known. Grazing animals can exhibit Zn deficiency when soils and forages contain limited concentrations of Zn. Pastures have been observed to be Zn-deficient in many parts of the world. However, non-ruminant animals usually receive adequate Zn when fed corn and soybean meal diets if there is not excessive Ca and Fe in their diets, but this is not true for rapidly growing young animals. Characteristics of a Zn deficiency include loss of appetite, reduced growth and reproduction, and impaired health of bone and skin tissues.

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“…Calves with lethal trait A46 exhibit thymus atrophy and reduced lymphocyte response to mitogen stimulation (Perryman et al 1989). The addition of 25 mg Zn/kg to a control diet that contained 33 mg Zn/kg increased body-weight gain by 10 % in growing steers (JW Spears and EB Kegley, unpublished results).…”

Section: Zincmentioning

confidence: 99%

Micronutrients and immune function in cattle

2000

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Complex inter-relationships exist between certain micronutrients, immune function and disease resistance in cattle. Several micronutrients have been shown to influence immune responses. The relationship between deficiencies of some micronutrients and disease resistance is less clear. A number of studies have indicated that Cr supplementation may improve cell-mediated and humoral immune response as well as resistance to respiratory infections in stressed cattle. With respiratory-disease challenge models Cr generally does not affect disease resistance. Deficiencies of Cu, Se, vitamin E and Co in cattle reduce the ability of isolated neutrophils to kill yeast and/or bacteria. Cu deficiency reduces antibody production, but cell-mediated immunity is generally not altered. However, Cu deficiency appears to reduce production of interferon and tumour necrosis factor by mononuclear cells. Numerous studies have linked low vitamin E and/or Se status to increased susceptibility of dairy cows to intramammary infections. In contrast to findings in laboratory animals, marginal Zn deficiency does not appear to impair antibody production or lymphocyte responsiveness to mitogen stimulation in ruminants. Co deficiency has been associated with reduced resistance to parasitic infections. It is well documented that vitamin A-deficient animals are more susceptible to various types of infections. β-Carotene, possibly via its antioxidant properties, may affect immune function and disease resistance independent of its role as a precursor of vitamin A.

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Lymphocyte alterations in zinc-deficient calves with lethal trait A46

Cited by 23 publications

References 17 publications

Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis

Analysis of the liver soluble proteome from bull terriers affected with inherited lethal acrodermatitis

Copper and Zinc Nutritional Issues for Agricultural Animal Production

Micronutrients and immune function in cattle

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