Copper and Zinc Nutritional Issues for Agricultural Animal Production

Hill, G. M.; Shannon, M. C.

doi:10.1007/s12011-018-1578-5

Cited by 109 publications

(72 citation statements)

References 146 publications

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“…The required amount of Zn by livestock is about 35 mg Zn kg −1 feed DM (Suttle 2010), although it might depend on the livestock type. Its deficiency can causes numerous disorders in livestock, such as skin parakeratosis, reduced or cessation of growth, general debility, lethargy, and increased susceptibility to infection (Hill and Shannon 2019).…”

Section: Introductionmentioning

confidence: 99%

Biofortification of Forage Peas with Combined Application of Selenium and Zinc Under Mediterranean Conditions

Reynolds-Marzal

Rivera-Martin

Rodrigo

et al. 2020

J Soil Sci Plant Nutr

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Agronomic biofortification can be used to alleviate the deficient intake of selenium (Se) and zinc (Zn) by livestock. These two essential micronutrients for human and animals play an important role in many physiological functions and biological processes. The aim of the present study was to evaluate the suitability of forage peas, crop with an increasing importance as plant protein source, to be biofortified with a combined treatment of Zn (as ZnSO 4-7H 2 O) and Se (as Na 2 SeO 4). A 2-year field experiment was established in southern Spain under semiarid Mediterranean conditions, by following a split-split-plot design. The study year (2017/2018, 2018/2019) was considered the main-plot factor, soil Zn application (50 kg Zn ha −1 , nil Zn) as a subplot factor, and foliar application (nil, 10 g Se ha −1 , 8 kg Zn ha −1 , 10 g Se ha −1 + 8 kg Zn ha −1) as a sub-subplot factor. The combined application of 50-kg soil Zn ha −1 and the foliar application of 10 g Se ha −1 + 8 kg Zn ha −1 was the most effective treatment to increase the concentration in forage of Zn and Se, 4-fold and 5-fold, respectively, as well as the Zn bioavailability, forage yield (close to 30%), and crude protein (~8%). Thus, forage peas could be considered a very suitable crop to be included in biofortification programs under Mediterranean conditions with Zn and Se as target minerals.

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Section: Introductionmentioning

confidence: 99%

Biofortification of Forage Peas with Combined Application of Selenium and Zinc Under Mediterranean Conditions

Reynolds-Marzal

Rivera-Martin

Rodrigo

et al. 2020

J Soil Sci Plant Nutr

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“…99 Zinc's direct impact on the gut microbiota and subsequent host growth has been evaluated in several studies of young livestock animals (piglets, calves, and broiler chickens) that differed in their design (dose levels, measurement time points, etc) and methods. [100][101][102] Most studies have reported small, beneficial effects-suggesting that Zn may shape the intestinal microbiota. However, a consensus is currently lacking.…”

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confidence: 99%

High‐dose dietary supplementation with zinc prevents gut inflammation: Investigation of the role of metallothioneins and beyond by transcriptomic and metagenomic studies

et al. 2020

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Although it is known that zinc has several beneficial roles in the context of gut inflammation, the underlying mechanisms have not been extensively characterized. Zinc (Zn) is known to be the primary physiological inducer of the expression of the metallothionein (MT) superfamily of small stress‐responsive proteins. The expression of MTs in various tissues is induced or enhanced (including the gastrointestinal tract (GIT)) by a variety of stimuli, including infection and inflammation. However, the MTs’ exact role in inflammation is still subject to debate. In order to establish whether or not MTs are the sole vectors in the Zn‐based modulation of intestinal inflammation, we used transcriptomic and metagenomic approaches to assess the potential effect of dietary Zn, the mechanisms underlying the MTs’ beneficial effects, and the induction of previously unidentified mediators. We found that the expression of endogenous MTs in the mouse GIT was stimulated by an optimized dietary supplementation with Zn. The protective effects of dietary supplementation with Zn were then evaluated in mouse models of chemically induced colitis. The potential contribution of MTs and other pathways was explored via transcriptomic analyses of the ileum and colon in Zn‐treated mice. The microbiota’s role was also assessed via fecal 16S rRNA sequencing. We found that high‐dose dietary supplementation with Zn induced the expression of MT‐encoding genes in the colon of healthy mice. We next demonstrated that the Zn diet significantly protected mice in the two models of induced colitis. When comparing Zn‐treated and control mice, various genes were found to be differentially expressed in the colon and the ileum. Finally, we found that Zn supplementation did not modify the overall structure of the fecal microbiota, with the exception of (i) a significant increase in endogenous Clostridiaceae, and (ii) some subtle but specific changes at the family and genus levels. Our results emphasize the beneficial effects of excess dietary Zn on the prevention of colitis and inflammatory events in mouse models. The main underlying mechanisms were driven by the multifaceted roles of MTs and the other potential molecular mediators highlighted by our transcriptomic analyses although we cannot rule out contributions by other factors from the host and/or the microbiota.

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“…43 Zinc deficiency, as a metabolic factor, has been reported to induce acanthosis and parakeratosis in different species including the horse. 15,22…”

Section: Discussionmentioning

confidence: 99%

Equine Hoof Canker: Bovine Papillomavirus Infection Is Not Associated With Impaired Keratinocyte Differentiation

et al. 2020

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Impaired keratinocyte differentiation has recently been suggested as a key event in equine hoof canker development. Koilocytotic appearance of keratinocytes, one of the most characteristic morphological alterations in hoof canker tissue, is also a common marker for papillomavirus (PV) infection, and bovine PV-1 and/or -2 (BPV-1/2) has previously been detected in equine canker patients. Therefore, the present study aimed to correlate the frequency and severity of koilocytotic keratinocytes with BPV detection in hoof canker samples. Hoof tissue of 5/18 canker-affected horses and 2/6 control horses tested positive for BPV-1/2 DNA using polymerase chain reaction. Thus, no association between the presence of BPV-1/2 papillomaviral DNA and koilocytotic appearance was found. Proteins associated with but not specific for PV infection were also investigated. Using immunohistochemistry, specific adhesion molecules (E-cadherin and β-catenin) and intermediate filaments (keratins 6 and 14) important for intact epidermal barrier function and keratinocyte differentiation were documented in control samples ( n = 6) and in hoof canker tissue samples ( n = 19). Altered expression patterns of intermediate filaments and adhesion molecules were demonstrated in canker tissue, confirming the importance of incomplete keratinocyte differentiation, as well as the crucial role of keratinocyte differentiation in hoof canker.

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Copper and Zinc Nutritional Issues for Agricultural Animal Production

Cited by 109 publications

References 146 publications

Biofortification of Forage Peas with Combined Application of Selenium and Zinc Under Mediterranean Conditions

Biofortification of Forage Peas with Combined Application of Selenium and Zinc Under Mediterranean Conditions

High‐dose dietary supplementation with zinc prevents gut inflammation: Investigation of the role of metallothioneins and beyond by transcriptomic and metagenomic studies

Equine Hoof Canker: Bovine Papillomavirus Infection Is Not Associated With Impaired Keratinocyte Differentiation

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