Lymphocyte abnormalities in untreated patients with Hodgkin's disease

Holm, G.; Mellstedt, Håkan; Björkholm, Magnus; Johansson, Bo; Killander, D.; Sundblad, R.; Söderberg, G.

doi:10.1002/1097-0142(197602)37:2<751::aid-cncr2820370223>3.0.co;2-2

Cited by 111 publications

(31 citation statements)

References 29 publications

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“…Since we could exclude the possibility that normal T cells were affected by products of HD B cells, such as anti-T antibodies, it is reasonable to suppose that the reduction of spontaneous IgG production in vitro reflects differences in the regulatory ability of normal and HD T lymphocytes. This possibility was further supported by the observation that the addition of T (39), which spontaneously synthesize DNA (40,41) and show similarities with lymphocytes detectable under conditions of known antigenic challenge (42,43). It is also consistent with the demonstration of in vivo production of migration-inhibitory lymphokinelike substances (44 …”

Section: Resultssupporting

confidence: 60%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

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A B S T R A C T The immunoglobulin-synthesizing activities of peripheral blood mononuclear cells from 57 untreated patients with Hodgkin's disease and 47 normal subjects were compared. Cumulative amounts of IgM and IgG synthesized and secreted by unstimulated and pokeweed mitogen-stimulated cells over a 7-d period were determined in a solid-phase radioimmunoassay. Synthesis of IgM in unstimulated cultures and of both IgM and IgG in cultures stimulated with pokeweed mitogen was markedly reduced in patients with Hodgkin's disease, whereas the mean level of the spontaneous IgG synthesis was enhanced. The degree and frequency of in vitro abnormalities were not influenced by disease stage or histology.Depression of pokeweed mitogen-induced immunoglobulin synthesis did not correlate with excessive number of monocytes and it was unaffected by removal of phagocytic cells or addition to the cultures of monocytes from normal individuals. On the other hand, monocytes isolated from blood of patients with Hodgkin's disease were even more effective than normal monocytes in supporting pokeweed mitogen-induced immunoglobulin synthesis by normal phagocyte-depleted mononuclear cells. Synthesis of both IgM and IgG induced by pokeweed mitogen remained subnormal after addition to patient B cell cultures of autologous irradiated T cells or allogeneic normal T lymphocytes. T cells from patients with Hodgkin's disease appeared at least as effective as normal T cells in helping pokeweed mitogen-induced immunoglobulin production by normal B cells. However, when normal T cells were co-cultured with B cells from patients with Hodgkin's disease, spontaneous IgG synthesis declined, whereas the addition of patient T cells

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Section: Resultssupporting

confidence: 60%

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Romagnani¹,

Prete²,

Maggi³

et al. 1983

J. Clin. Invest.

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“…An abnormal cell-mediated immune function is a typical feature of Hodgkin's disease. A decreased response in hypersensitivity skin tests, lymphopenia and an altered T helper/T suppressor cell ratio are commonly seen in Hodgkin's disease patients (4,5). In addition, the in vitro response of lymphocytes to phytohemagglutinin and the cytokine release are com¬ promised in patients with Hodgkin's disease (6,7).…”

mentioning

confidence: 99%

Acute beta-interferon or thymopentin administration increases plasma growth hormone and cortisol levels in children

Angioni

Iori²,

Cellini³

et al. 1992

Acta Endocrinologica

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The interaction between the immune and endocrine systems has recently been investigated. Hodgkin's disease represents a model of immune disturbance frequently associated with endocrine impairment. The present study evaluated the effect of the acute administration of \g=b\-interferon or thymopentin on plasma growth hormone, prolactin and cortisol levels in children with Hodgkin's disease (N = 8) and age-and sex-matched healthy controls (N= 8). \g=b\-interferon(1 000 000 IU), thymopentin (50 mg) or placebo (saline) were injected after two basal blood samples (\m=-\15 and 0) and further samples were drawn at 15, 30, 45, 60, 90 and 120 min. Plasma growth hormone, prolactin and cortisol levels were measured by specific RIAs. Plasma prolactin levels did not show significant change following \ g = b \ \ x = r e q -\ interferon or thymopentin injection in either the controls or the patients. In the patients with Hodgkin's disease, \g=b\-interferoninjection induced a significant increase in both plasma growth hormone and cortisol levels, while thymopentin was not effective. In controls both thymopentin and \g=b\-interferon administration increased plasma growth hormone and cortisol levels. These results indicate that \ g = b \ \ x = r e q -\ interferon and thymopentin are immune substances active on the release of growth hormone and cortisol in healthy children. The lack of effect of thymopentin in children with Hodgkin's disease suggests an impairment of the immune-endocrine interaction in these patients.

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“…However, it is also known that before starting any treatment, patients present with disorders in their immune status. The blood lymphocytes of patients with untreated Hodgkin's disease are poorly activated by mitogens and antigens, which preferentially stimulate T cells (23). In addition, all patients with Hodgkin's disease should be advised of their increased risk of bacterial sepsis and opportunistic infections.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Competing Risks of Causes of Death and their Variation Over Different Time Periods in Hodgkin's Disease

Provencio¹,

Millán²,

España³

et al. 2008

Clinical Cancer Research

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Purpose: Hodgkin's disease is considered a model of curable illness. However, long-term studies show excessive mortality in relation to the general population. We studied the various causes of death by use of competing risks and their evolution over the years. Experimental Design: All patients diagnosed with Hodgkin's disease at our institution between 1967 and 2003 were included. The competing risks of causes of death and their vital situation were examined in three time periods: cohort A with patients treated before 1980, cohort B with patients treated from 1981to 1986, and cohort C with patients treated from 1986 onwards. Results:We studied 534 patients, with a median follow-up time of 9.1years for the whole cohort.The 5-year, 15-year, and 20-year Kaplan-Meier survival estimates for all patients were 81%, 72%, and 65%, respectively. At the close of the study, 337 (63.1%) were alive and170 (31.8%) patients had died. The most common cause of death was the progression of Hodgkin's disease, followed by deaths due to a second tumor. Survival was significantly worse in the first period than in the other two (P < 0.001), and in the three periods, the main cause of death was tumor progression. Conclusions:The progression of Hodgkin's disease is the main cause of death. Over time, a reduction in death related to infection and the acute toxicity of treatment was seen. A lot of patients still die for reasons linked to delayed side effects of radiotherapy, such as second tumors and heart disease, which is important to plan preventive activities and clinical research.

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Lymphocyte abnormalities in untreated patients with Hodgkin's disease

Cited by 111 publications

References 29 publications

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.

Acute beta-interferon or thymopentin administration increases plasma growth hormone and cortisol levels in children

Analysis of Competing Risks of Causes of Death and their Variation Over Different Time Periods in Hodgkin's Disease

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