Lymphocyte Abnormalities in Myeloma

Sewell, R. L.

doi:10.1111/j.1365-2141.1977.tb00995.x

Cited by 16 publications

(4 citation statements)

References 13 publications

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“…Our 4 patients with lambda light chains presented a high total number of monocytes. This may be coincidence only, but in a study by Sewel (21) monocytosis (defined as more than 800 x lob cells/ 1 blood) was found in 19 out of 62 patients with MM. Unfortunately, no information on the light chain type of the serum M-component was given for this material.…”

Section: Discussionmentioning

confidence: 91%

A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

Blom

Nielsen

Larsen

et al. 1984

Scandinavian Journal of Haematology

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Selected functions (i.e. phagocytosis and chemotaxis of circulating blood monocytes were studied on cells obtained from 20 patients with untreated multiple myeloma (MM) and the results were compared with those obtained on cells from 60 healthy persons. The mean number of circulating monocytes was only slightly increased over the normal value although a marked monocytosis was demonstrated in all of the 4 patients with M‐components of the lambda light chain type. Plasma cells isolated from peripheral blood and from bone marrow of patients with MM were found to possess a strong a‐naphthyl acetate esterase activity. No differences were observed in the phagocytic activity of monocytes from patients compared with those of the controls, whereas the chemotactic responsiveness of the monocytes from the patients was slightly increased.

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Section: Discussionmentioning

confidence: 91%

A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

Blom

Nielsen

Larsen

et al. 1984

Scandinavian Journal of Haematology

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“…Lymphopenia was reported in one third of patients with multiple myeloma [23]. Since the majority of our patients have been treated with var ious chemotherapeutic agents, lymphopenia, which was seen in some of them, could not be meaningfully analyzed.…”

Section: Discussionmentioning

confidence: 98%

Lymphocytotoxic Activity of Monoclonal Immunoglobulins in Plasmalymphocytic Diseases

Pruzanski¹,

Capes²,

Ramírez³

et al. 1985

Acta Haematol

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95 of 1,019 (9.3%) sera with monoclonal immunoglobulins (MIg) were found to have cold-reacting lymphocytotoxins (LCT). There was no difference in the prevalence of LCT in multiple myeloma, macroglobulinemia, cancer, lymphoma or benign monoclonal gammopathy. Prevalence of LCT was similar in various classes and types of MIg with the exception of the IgG/λ group in which LCT were more common than in IgG/K (p = 0.013). IgMs had the most potent whereas IgAs had the weakest LCT activity.MIg were purified from 61 LCT-positive sera. 25 pure MIg (41 %) had LCT activity. In the rest, LCT activity resided in other fractions. 64 sera with LCT were tested against B and T cells; 56% were equally cytotoxic to B and T cells, 39% killed more B cells and 5% killed more T cells. 18 purified lymphocytotoxic MIg killed both B and T cells. When serial dilutions of sera, and of purified MIg were tested, in all but one instance the reactivity with the T cells weakened more than that with the B cells. Lymphocytotoxins absorbed to and eluted from the peripheral blood lymphocytes or separately from B or from T cells retained LCT activity against B and T lymphocytes.It may be concluded that about one tenth of sera with M components have lymphocytotoxic activity and that in about 40% of these positive sera, this activity is related to the monoclonal immunoglobulins. LCT react with both B and T cells. Antilymphocyte activity of MIgs may play a role in immunoregulatory abnormalities in plasmalymphocytic diseases.

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“…Therefore, different mechanisms for impaired antibody production probably coexist. Sewell (1977) has described monocytosis in the peripheral blood of patients with myelomatosis. Also increased monocyte function, as measured by phytohaemagglutinin-induced cytotoxicity to CRBC, has been rzported in this disease (Yonkosky, 1977).…”

Section: Discussionmentioning

confidence: 99%

Immune suppression in BALB/c mice bearing the plasmacytoma TEPC‐183: Evidence for normal lymphocyte but defective macrophage function

Joshua

Brown

MacLennan

1979

Intl Journal of Cancer

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This paper analyses impairment of the primary immune response of mice bearing the plasmacytoma TEPC-183. Healthy animals and mice bearing the reported non-immunosuppressive tumour MOPC-104E were used as controls. The defect was shown to affect both primary IgG and IgM responses to chicken cells (CRBC) and to be related to tumour size. However, the primary immune depression could be overcome either by increasing the antigen dose or by using Freund's complete adjuvant together with antigen. Secondary responses were also depressed. This depression was more pronounced if the animals was primed after, rather than before, tumour implantation. Further studies involved the measurement of primary immune responses of immunologically deprived syngeneic mice, after they had been reconstituted with cells from normal or tumour-bearing mice. Lymphocyte reconstitution experiments were carried out in mice which had been irradiated with 950R. Various lymphoid preparations from TEPC-183-bearing mice were unable to bring about such restoration. It is concluded that the impairment of the primary immune response of mice bearing the plasmacytoma TEPC-183 is due to a macrophage, rather than a lymphocyte, abnormality. However, none of these transfer studies suggested that positive suppression of primary immune responses was being mediated by cells from TEPC-183-bearing mice.

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Lymphocyte Abnormalities in Myeloma

Cited by 16 publications

References 13 publications

A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

Lymphocytotoxic Activity of Monoclonal Immunoglobulins in Plasmalymphocytic Diseases

Immune suppression in BALB/c mice bearing the plasmacytoma TEPC‐183: Evidence for normal lymphocyte but defective macrophage function

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