A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

Blom, Jens; Nielsen, Henrik; Larsen, Severin Olesen; Mansa, B.

doi:10.1111/j.1600-0609.1984.tb00720.x

Cited by 2 publications

References 16 publications

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Infections in Patients with Leukemia and Lymphoma

Morrison

2014

Cancer Treatment and Research

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Infectious complications remain a significant issue in the care of patients with hematologic malignancies. Inherent immune defects related to the primary disease process are present in patients with disorders such as chronic lymphocytic leukemia, multiple myeloma, hairy cell leukemia, and Hodgkin lymphoma. Therapy-related immunosuppression is also commonplace in these patients. This includes not only treatment-related neutropenia, but also defects in cell-mediated immunity, such as those that occur with purine analog therapy. In this chapter, we will review the pathogenesis of infection in these disorders, as well as the spectrum of infectious complications seen and suggested strategies for the prevention of infection.

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Infections in Patients with Leukemia and Lymphoma

Morrison

2014

Cancer Treatment and Research

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Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin‐2 receptors

Nielsen

Tvede

et al. 1991

APMIS

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Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin-2 receptors. APMIS 99: 34G346, 1990.Multiple myeloma (MM) is characterized by an increased susceptibility to infections and to other malignancies. Selected related immune functions were studied. Spontaneous and interleukin-2-stimulated natural killer (NK) cell activities were normal in 19 patients with MM compared with 62 controls. In contrast, interferon-stimulated N K cells had a significantly lower increase in activity in M M than in controls. The normal improvement in lytic N K cell activity after addition of indomethacin to the mononuclear cell cultures (to inhibit prostaglandin-mediated suppression) was not observed in cultures from M M patients. As reported for other lymphoproliferdtive disorders, the levels of soluble interleukin-2 receptors in serum were significantly higher in M M (600 U/ml median value) compared with controls (317 U/ml median value), P < 0.0001, and the concentration of interleukin-2 receptors was significantly correlated with the concentration of monoclonal immunoglobulin in serum. Blood monocyte chemotactic responsiveness was significantly lower in M M patients with both zymosanactivated serum and f-Met-Leu-Phe as cytotaxins, suggesting reduced ability to accumulate at inflammatory foci. In contrast, release of reactive oxygen radicals, believed to be associated with the killing ability of monocytes, was normal after in v i~o stimulation.

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A study of certain functional parameters of monocytes from patients with multiple myeloma: Comparison with monocytes from healthy individuals

Cited by 2 publications

References 16 publications

Infections in Patients with Leukemia and Lymphoma

Infections in Patients with Leukemia and Lymphoma

Immune dysfunction in multiple myeloma. Reduced natural killer cell activity and increased levels of soluble interleukin‐2 receptors

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