Lymphocutaneous Nocardia Brasiliensis Infection: A Pediatric Case Cured With Amoxicillin/Clavulanate

Nolt, Dawn; Wadowsky, Robert M.; Green, Michael

doi:10.1097/00006454-200010000-00022

Cited by 18 publications

(3 citation statements)

References 15 publications

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“…This in vitro finding has been reported previously (33), and on the basis of these data, amoxicillin-clavulanic acid has successfully been used as treatment for a few cases of cutaneous N. brasiliensis infection (9,26,39). However, more extensive clinical trials should be carried out since the combination amoxicillin-clavulanic acid is not active in vitro against 100% of strains, and secondary resistance has seldom been reported to occur (28).…”

Section: Discussionsupporting

confidence: 72%

In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis

Gomez-Flores

Welsh

Said‐Fernández³

et al. 2004

Antimicrob Agents Chemother

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In Mexico mycetomas are mostly produced by Nocardia brasiliensis, which can be isolated from about 86% of cases. In the present work, we determined the sensitivities of 30 N. brasiliensis strains isolated from patients with mycetoma to several groups of antimicrobials. As a first screening step we carried out disk diffusion assays with 44 antimicrobials, including aminoglycosides, cephalosporins, penicillins, quinolones, macrolides, and some others. In these assays we observed that some antimicrobials have an effect on more than 66% of the strains: linezolid, amikacin, gentamicin, isepamicin, netilmicin, tobramycin, minocycline, amoxicillin-clavulanic acid, piperacillin-tazobactam, nitroxolin, and spiramycin. Drug activity was confirmed quantitatively by the broth microdilution method. Amoxicillin-clavulanic acid, linezolid, and amikacin, which have been used to treat patients, were tested in an experimental model of mycetoma in BALB/c mice in order to validate the in vitro results. Linezolid showed the highest activity in vivo, followed by the combination amoxicillin-clavulanic acid and amikacin.

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Section: Discussionsupporting

confidence: 72%

In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis

Gomez-Flores

Welsh

Said‐Fernández³

et al. 2004

Antimicrob Agents Chemother

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“…7 Primary lymphocutaneous nocardiosis may be curable after a course of two to four months, although several studies report clinical cures of cutaneous nocardiosis caused by N. brasiliensis after only two to three weeks of therapy. 1,[8][9][10][11] In patients with sulfa intolerance or those who fail therapy with trimethoprim-sulfamethoxazole, alternative therapy must be based on sensitivity testing. Minocycline, tetracycline, amikacin and amoxicillin-clavulanic acid have been successfully used.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Nocardia brasiliensis infection in an immunocompetent host after ovarian cystectomy: A case study.

Sarkar

Saha²,

Sengupta³

2011

amj

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Nocardia brasiliensis is a rare human pathogen that is usually associated with localised cutaneous infections. We report a case of primary cutaneous Nocardia brasiliensis infection causing delayed wound healing that developed after ovarian cystectomy in an otherwise healthy 32-year-old woman. The patient was initially treated with cotrimoxazole, however due to intolerance intravenous amikacin was given and gradually the wound healed. The diagnosis was confirmed by demonstrating the causative organism in exudates, and cultures. Early diagnosis as well as early institution of chemotherapy is effective in most patients, and antimicrobial susceptibility testing of the isolate should be performed to identify the best treatment options.

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“…In patients with sulfa intolerance or those who fail therapy with trimethoprim-sulfamethoxazole, alternative therapy must be based on sensitivity testing. Minocycline, tetracycline, amikacin and amoxicillin-clavulanic acid have been successfully used [11]. …”

Section: Discussionmentioning

confidence: 99%

Primary lymphocutaneous nocardiosis in an immunocompetent patient

Maraki

Chochlidakis

Nioti

et al. 2004

Ann Clin Microbiol Antimicrob

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BackgroundNocardia brasiliensis is a rare human pathogen usually associated with localized cutaneous infections.Case PresentationWe report a case of primary lymphocutaneous Nocardia brasiliensis infection developed after a bone fracture of the left hand of an otherwise healthy 32-year-old man. Treatment with trimethoprim-sulfamethoxazole given for a total of three months combined with surgical debridement resulted in complete resolution of the infection.ConclusionNocardiosis should be part of the differential diagnosis in patients with sporotrichoid infection, particularly those with a history of outdoor injury. Culture of the affected tissue and antimicrobial susceptibility testing of the isolate should be performed for diagnosis and treatment.

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Lymphocutaneous Nocardia Brasiliensis Infection: A Pediatric Case Cured With Amoxicillin/Clavulanate

Cited by 18 publications

References 15 publications

In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis

In Vitro and In Vivo Activities of Antimicrobials against Nocardia brasiliensis

Cutaneous Nocardia brasiliensis infection in an immunocompetent host after ovarian cystectomy: A case study.

Primary lymphocutaneous nocardiosis in an immunocompetent patient

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