Cutaneous Nocardia brasiliensis infection in an immunocompetent host after ovarian cystectomy: A case study.

Sarkar, Shubhashish; Saha, Puranjay; Sengupta, Mallika

doi:10.4066/amj.2011.898

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…It was reported that cutaneous nocardiosis accounted for about 7.8%–10% of nocardiosis cases, of which the primary type is relatively rare with no exact prevalence. 3 , 4 But it may have been underestimated because it is always misdiagnosed and treated as cellulitis or other similar diseases when culture is not available or confirmative. Unlike other forms of nocardiosis, primary cutaneous disease usually develops in immunocompetent patients.…”

Section: Discussionmentioning

confidence: 99%

An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by <em>Nocardia brasiliensis</em>

Chen

Qin

Sun

et al. 2018

TCRM

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IntroductionPrimary cutaneous nocardiosis is a rare suppurative or granulomatous inflammation disease caused by Nocardia infection. Because of nonspecific clinical findings, it is always misdiagnosed as common pyogenic infection. Sulfonamides have been the standard treatment for nocardiosis, but the outcome is always poor due to the high rates of misdiagnosis and refractoriness of the disease.Cases presentationsThe presented cases are patients of acute suppurative cutaneous infection without involvement of other organs. We report four cases, of which two cases were localized cutaneous nocardiosis and the other two were lymphocutaneous type of nocardiosis. All cases were diagnosed with pus culture which turned out to be Nocardia brasiliensis. We report an improvement of primary cutaneous nocardiosis symptoms in the four patients treated with non-sulfonamides. All patients were cured and recovered without recurrence during follow-up.ConclusionOur results suggest that non-sulfonamides are effective treatment for the patients with primary cutaneous nocardiosis who are resistant or intolerant to sulfonamides.

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Section: Discussionmentioning

confidence: 99%

An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by <em>Nocardia brasiliensis</em>

Chen

Qin

Sun

et al. 2018

TCRM

View full text Add to dashboard Cite

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Uncommon lymphocutaneous cellulitis after insect bite: a case report of primary cutaneous nocardiosis and literature review

et al. 2022

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Nocardia is a genus of aerobic actinomycetes that are usually responsible for opportunistic infection in immunocompromised patients. Less frequently nocardiosis can interest immunocompetent population, causing especially primary cutaneous infections. Cutaneous involvement by Nocardia spp. may occur mostly as one of four clinical manifestations: superficial cellulitis or abscess, mycetoma, lymphocutaneous (also defined "sporotrichoid") infection and secondary cutaneous involvement from systemic disease. Infections usually present after minor local injury, especially in traumatic outdoor activities (e.g. gardeners, farmers, road accidents), with subsequent environmental contamination of the wound. In sporadic cases cutaneous infection follows an insect bite. Microbiological diagnosis is often difficult to obtain and N. brasiliensis is the species isolated in most cases (80%). We present the case of a 45-year-old female with fever and a painful and necrotizing lesion on her right leg with secondary ascending lesions occurred on the homolateral knee and SUMMARY consensual groin lymphadenopathy after insect sting (maybe a spider bite). Cultures on skin biopsy identified Nocardia brasiliensis. Infection was completely healed after 5 months of targeted antibiotic therapy. In addition, we performed a literature review of all cutaneous nocardiosis cases in immunocompetent individuals, finding that only in 22 cases the infection presented after insect bite; in most of these cases lymphocutaneous manifestation was seen and N. brasiliensis was the Nocardia species isolated. Our case, along with others in literature, reveals that the real burden of soft-tissues nocardiosis seems low but probably many cases might go undiagnosed because of difficulties in microbiology diagnosis. Primary cutaneous nocardiosis should be included in the diagnostic pathway in cases of cellulitis following insect bite or sting, especially when localized to extremities.

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Cutaneous Nocardia brasiliensis infection in an immunocompetent host after ovarian cystectomy: A case study.

Cited by 2 publications

References 11 publications

An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by <em>Nocardia brasiliensis</em>

An unusual successful treatment with non-sulfonamides: primary cutaneous nocardiosis caused by <em>Nocardia brasiliensis</em>

Uncommon lymphocutaneous cellulitis after insect bite: a case report of primary cutaneous nocardiosis and literature review

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