Lymphoblastic lymphoma: Cytogenetic, pathologic, and immunologic studies

Abstract

Cytogenetic, pathologic, and immunologic studies were done on 10 patients with lymphoblastic lymphoma (LL). The median age was 21 years, and males predominated in a ratio of 9:1. At the time of diagnosis, 6 of the 10 patients had an anterior mediastinal mass, 3 had bone marrow involvement, and 2 had central nervous system involvement. All patients were treated with intensive combination chemotherapy. The median survival of the 8 patients who died (7 of whom were adults) was 10.5 months; all 8 achieved only a partial remission. Two other patients were children; they continue in complete remission. Immunologic marker studies were done on 9 of the patients; 5 had T-cell LL, and the other 4 had non-T, non-B LL. In a study of T-cell subpopulations with the use of monoclonal antibodies, the malignant T cells of the 2 patients tested appeared to be mature thymocytes. Clonal chromosome abnormalities were seen in involved tissues from 8 patients; the other 2 patients had a normal karyotype. A 9q+ chromosome, a 6q- chromosome, and a 1q-chromosome associated with 1q trisomy were each seen in 2 patients. No patients had a 14q+ chromosome, which is the most common abnormality in various lymphoproliferative disorders, including other T-cell malignant diseases. The variable chromosome pattern in LL could be related to the heterogeneity of the immunologic phenotype of the malignant T cells. More data are needed before it can be established whether there are any correlations between a particular karyotype and the immunologic phenotype of LL cells.

Clusters of chromosome 9 aberrations are associated with clinico‐pathologic subsets of non‐Hodgkin's lymphoma

“…This clinicopathologic subset of N H L was characterized by a T-cell immunophenotype and a high incidence of lymphoblastic histology. These findings confirm previous case reports of recurring 9q34 breaks in lymphoblastic lymphoma (Kaneko et al, 1982(Kaneko et al, , 1988Arenson et al, 1989). T h e case of t(9;22)(q34;qll) reported here probably represents an extramedullary transformation in CML, although in another case of N H L with a complex Ph chromosome, an aberrant 190kD BCR-ABL protein was demonstrated, suggesting a similarity to Ph-positive ALL (Mitani et al, 1990).…”

United states non‐Hodgkin's lymphoma surveillance by occupation 1984‐1989: A twenty‐four state death certificate study

“…These substances have been associated with NHL in other studies [Blair et al, 1993;Spirtas et al, 1991;Dalager et al, 1991;Teta et al, 1990;Christie, 1990;Linos et al, 1991;Brandt et al, 1983Brandt et al, , 1989Corbett and O'Neill, 1988;Olsson and Brandt, 1988;Garland et al, 1988;Tsongas, 1985;Giles et al, 1984;Doln et al, 1983; Kaneko et al, 1982;Fischmann et al, 19791 and with occupations in which these exposures may occur, including miners [Corbett and O'Neill, 1988;Giles et al, 19841, foundry workers [Giles et al, 19841, petrochemical workers [Christie, 19901, workers exposed to solvents [Brandt et al, 1983[Brandt et al, , 1989Fischmann et al, 1979;Vianna and Polan, 19791, plumbers [Doln et al, 19831, and chemists [Teta et al, 19901. We found no excess among painters, as reported by others [Chow, et al, 19931. Increased risk of NHL has been reported among physicians [Grufferman et al, 1976, Vianna et al, 1974Petersen and Milham, 1980;Milham, 1983;Dubrow and Wegman, 1984;Scherr et al, 1992;Blair et al, 19933.…”

Philadelphia-like translocation t(9;22)(q34;q11) found in a follicular lymphoma involving notBCR andABL butIGL-mediated rearrangement of an unknown gene on 9q34

“…Occurrence of 9q34 abnormalities in NHL has been previously reported (Mitelman, 1994). Some authors correlated breakpoints at 9q34 with lymphoblastic lymphomas (Kaneko et al, 1982(Kaneko et al, , 1988Arenson et al, 1989), others with high-grade T-cell lymphomas (Offit et al, 1993). Whether the putative new gene rearranged by a t(9;22) in our case is affected in other NHLs with 9q34 abnormalities, however, remains to be evaluated, and the significance of the t(9; 22)(q34;q11) in the development or progression of the reported lymphoma case is unknown.…”